A Study to Compare the Efficacy and Safety of BMS-986489 (Atigotatug+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).
NCT06646276
This study is recruiting at 18 US sites in 13 states, according to its ClinicalTrials.gov record last updated .
Summary
The Purpose of the Study is to Compare the Efficacy and Safety of BMS-986489 (Anti-fucosyl-GM1+ Nivolumab Fixed Dose Combination) in Combination with Carboplatin plus Etoposide to that of Atezolizumab with Carboplatin plus Etoposide as First-Line Therapy in Participants with Extensive-Stage Small Cell Lung Cancer.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Extensive-Stage Small Cell Lung Cancer
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Bristol-Myers Squibb
- Last updated on ClinicalTrials.gov
- October 13, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- Southern Cancer Center, PC · Daphne, AL
Florida · 3
- Florida Cancer Specialists - South · Fort Myers, FL
- Mid Florida Hematology and Oncology Center · Orange City, FL
- Florida Cancer Specialists - North · St. Petersburg, FL
Georgia · 1
- Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital · Marietta, GA
Illinois · 1
- Illinois Cancer Care · Peoria, IL
New Mexico · 1
- University of New Mexico Comprehensive Cancer Center · Albuquerque, NM
North Carolina · 1
- Duke Cancer Institute · Durham, NC
North Dakota · 2
- Sanford Medical Center · Bismarck, ND
- Sanford Fargo Medical Center · Fargo, ND
Ohio · 1
- Oncology Hematology Care · Cincinnati, OH
South Dakota · 1
- Sanford Cancer Center · Sioux Falls, SD
Tennessee · 1
- SCRI Oncology Partners · Nashville, TN
Texas · 2
- Texas Oncology - Central/South Texas · Austin, TX
- Texas Oncology - Northeast Texas · Tyler, TX
Virginia · 1
- Oncology & Hematology Associates of Southwest Virginia, Inc. · Roanoke, VA
Washington · 2
- Swedish Cancer Institute - Edmonds · Edmonds, WA
- Swedish Medical Center · Seattle, WA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.