The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma
NCT06606119
This study is recruiting at 3 US sites in 1 state, according to its ClinicalTrials.gov record last updated .
Summary
Traumatic injury followed by critical illness provokes pathophysiologic changes in the bone marrow and the gut that contribute to persistent anemia and changes in the microbiome which significantly impact long-term recovery. This project will define the interactions between the stress, chronic inflammation, bone marrow dysfunction, and an altered microbiome which will provide a strong foundation for future clinical interventions to help improve outcomes following severe trauma.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Trauma Injury
- Trauma
- Critical Illness
- Microbiome
- Chronic Anemia
- Acute Blood Loss Anemia
Eligibility basics and study details
- Study type
- Observational
- Phase
- Not applicable
- Ages
- 18 to 100 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- University of Florida
- Last updated on ClinicalTrials.gov
- February 6, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Florida · 3
- UF Academic Research Building · Gainesville, FL
- UF Health at Shands Hospital · Gainesville, FL
- UF Laboratory of Inflammation Biology and Surgical Science and Shands Hospital at UF · Gainesville, FL
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.