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A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%

NCT06561386

This study is recruiting at 23 US sites in 14 states, according to its ClinicalTrials.gov record last updated .

Summary

The purpose of this study is to compare the efficacy of Nivolumab and Relatlimab in combination with chemotherapy to Pembrolizumab with Chemotherapy in participants with stage IV or recurrent Non-squamous Non-small Cell Lung Cancer with PD-L1 expression ≥ 1%

Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov

Conditions studied

  • Non-small Cell Lung Cancer

Eligibility basics and study details

Study type
Interventional
Phase
Phase 3
Ages
18 years and older
Sex
All
Healthy volunteers
Not accepted
Sponsor
Bristol-Myers Squibb
Last updated on ClinicalTrials.gov
September 23, 2026

These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.

US recruiting sites

Arizona · 1

  • Southern Arizona VA Health Care System · Tucson, AZ

California · 2

  • University of California Davis (UC Davis) Comprehensive Cancer Center · Sacramento, CA
  • UCLA Hematology/Oncology - Santa Monica · Santa Monica, CA

Florida · 4

  • Memorial Hospital West · Pembroke Pines, FL
  • Florida Cancer Specialists - North · St. Petersburg, FL
  • Florida Clinical Trials Group. · Tamarac, FL
  • Florida Cancer Specialists - East · West Palm Beach, FL

Illinois · 1

  • Affiliated Oncologists, LLC · Chicago Ridge, IL

Kansas · 1

  • Cancer Center of Kansas · Wichita, KS

Kentucky · 2

  • Saint Elizabeth Medical Center Edgewood · Edgewood, KY
  • Baptist Health Lexington · Lexington, KY

Michigan · 1

  • Profound Research LLC - MHP MedOnc Royal Oak - Oakland Medical Group Location · Royal Oak, MI

Mississippi · 1

  • Hattiesburg Clinic Hematology/Oncology · Hattiesburg, MS

Nevada · 1

  • Renown Regional Medical Center · Reno, NV

New York · 3

  • Veterans Affairs New York Harbor Healthcare System · New York, NY
  • University of Rochester Medical Center · Rochester, NY
  • SUNY Upstate Medical University · Syracuse, NY

North Carolina · 1

  • East Carolina University · Greenville, NC

Ohio · 1

  • University of Cincinnati Medical Center · Cincinnati, OH

Pennsylvania · 1

  • Lancaster General Hospital - Ann B Barshinger Cancer Institute · Lancaster, PA

Texas · 3

  • Texas Oncology - West Texas · Abilene, TX
  • University of Texas MD Anderson Cancer Center · Houston, TX
  • The University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center · Tyler, TX

Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.