A Study Comparing the Combination of Pembrolizumab and Sacituzumab Govitecan-hziy Versus Standard of Care in the Treatment of Advanced Urothelial Cancer
NCT06524544
This study is recruiting at 160 US sites in 30 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase III trial compares the effectiveness of pembrolizumab and sacituzumab govitecan-hziy to standard of care in treating patients with urothelial cancer that has spread to nearby tissue or lymph nodes (locally advanced) or that has spread to other places in the body (metastatic). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Locally Advanced Urothelial Carcinoma
- Metastatic Urothelial Carcinoma
- Unresectable Urothelial Carcinoma
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- National Cancer Institute (NCI)
- Last updated on ClinicalTrials.gov
- October 5, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 1
- Cancer Center at Saint Joseph's · Phoenix, AZ
California · 2
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care · Irvine, CA
- UC Irvine Health/Chao Family Comprehensive Cancer Center · Orange, CA
Florida · 1
- UF Health Cancer Institute - Gainesville · Gainesville, FL
Georgia · 3
- Emory Saint Joseph's Hospital · Atlanta, GA
- Emory University Hospital Midtown · Atlanta, GA
- Emory University Hospital/Winship Cancer Institute · Atlanta, GA
Idaho · 3
- Kootenai Health - Coeur d'Alene · Coeur d'Alene, ID
- Kootenai Clinic Cancer Services - Post Falls · Post Falls, ID
- Kootenai Clinic Cancer Services - Sandpoint · Sandpoint, ID
Illinois · 16
- University of Illinois · Chicago, IL
- Carle at The Riverfront · Danville, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Carle Physician Group-Effingham · Effingham, IL
- Crossroads Cancer Center · Effingham, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- Carle BroMenn Medical Center · Normal, IL
- Carle Cancer Institute Normal · Normal, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- HSHS Saint Elizabeth's Hospital · O'Fallon, IL
- Memorial Hospital East · Shiloh, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Springfield Clinic · Springfield, IL
- Springfield Memorial Hospital · Springfield, IL
- Carle Cancer Center · Urbana, IL
Iowa · 6
- Mary Greeley Medical Center · Ames, IA
- McFarland Clinic - Ames · Ames, IA
- Mercy Hospital · Cedar Rapids, IA
- Oncology Associates at Mercy Medical Center · Cedar Rapids, IA
- McFarland Clinic - Trinity Cancer Center · Fort Dodge, IA
- McFarland Clinic - Marshalltown · Marshalltown, IA
Kansas · 8
- HaysMed · Hays, KS
- University of Kansas Cancer Center · Kansas City, KS
- Lawrence Memorial Hospital · Lawrence, KS
- The University of Kansas Cancer Center - Olathe · Olathe, KS
- University of Kansas Cancer Center-Overland Park · Overland Park, KS
- Salina Regional Health Center · Salina, KS
- University of Kansas Health System Saint Francis Campus · Topeka, KS
- University of Kansas Hospital-Westwood Cancer Center · Westwood, KS
Kentucky · 2
- The James Graham Brown Cancer Center at University of Louisville · Louisville, KY
- UofL Health Medical Center Northeast · Louisville, KY
Louisiana · 2
- Louisiana Hematology Oncology Associates LLC · Baton Rouge, LA
- Mary Bird Perkins Cancer Center - Metairie · Metairie, LA
Massachusetts · 1
- UMass Memorial Medical Center - University Campus · Worcester, MA
Michigan · 7
- Trinity Health IHA Medical Group Hematology Oncology - Brighton · Brighton, MI
- Trinity Health IHA Medical Group Hematology Oncology - Canton · Canton, MI
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital · Chelsea, MI
- University of Michigan Health - Sparrow Lansing · Lansing, MI
- Trinity Health Saint Mary Mercy Livonia Hospital · Livonia, MI
- Trinity Health Saint Joseph Mercy Oakland Hospital · Pontiac, MI
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus · Ypsilanti, MI
Minnesota · 13
- Essentia Health Saint Joseph's Medical Center · Brainerd, MN
- Mercy Hospital · Coon Rapids, MN
- Essentia Health - Deer River Clinic · Deer River, MN
- Essentia Health Cancer Center · Duluth, MN
- Fairview Southdale Hospital · Edina, MN
- Essentia Health Hibbing Clinic · Hibbing, MN
- Avera Cancer Institute at Marshall · Marshall, MN
- Abbott-Northwestern Hospital · Minneapolis, MN
- Park Nicollet Clinic - Saint Louis Park · Saint Louis Park, MN
- Regions Hospital · Saint Paul, MN
- United Hospital · Saint Paul, MN
- Essentia Health Sandstone · Sandstone, MN
- Essentia Health Virginia Clinic · Virginia, MN
Missouri · 14
- Saint Francis Medical Center · Cape Girardeau, MO
- Siteman Cancer Center at Saint Peters Hospital · City of Saint Peters, MO
- Siteman Cancer Center at West County Hospital · Creve Coeur, MO
- Parkland Health Center - Farmington · Farmington, MO
- University Health Truman Medical Center · Kansas City, MO
- University of Kansas Cancer Center - Briarcliff · Kansas City, MO
- University of Kansas Cancer Center - North · Kansas City, MO
- University of Kansas Cancer Center - Lee's Summit · Lee's Summit, MO
- Sainte Genevieve County Memorial Hospital · Sainte Genevieve, MO
- Missouri Baptist Medical Center · St Louis, MO
- Siteman Cancer Center at Christian Hospital · St Louis, MO
- Siteman Cancer Center-South County · St Louis, MO
- Washington University School of Medicine · St Louis, MO
- Missouri Baptist Sullivan Hospital · Sullivan, MO
Montana · 6
- Community Hospital of Anaconda · Anaconda, MT
- Billings Clinic Cancer Center · Billings, MT
- Bozeman Health Deaconess Hospital · Bozeman, MT
- Benefis Sletten Cancer Institute · Great Falls, MT
- Logan Health Medical Center · Kalispell, MT
- Community Medical Center · Missoula, MT
New Hampshire · 1
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center · Lebanon, NH
New Jersey · 6
- Cooperman Barnabas Medical Center · Livingston, NJ
- Monmouth Medical Center · Long Branch, NJ
- Rutgers Cancer Institute of New Jersey · New Brunswick, NJ
- Rutgers New Jersey Medical School · Newark, NJ
- Robert Wood Johnson University Hospital Somerset · Somerville, NJ
- Community Medical Center · Toms River, NJ
New York · 3
- Roswell Park Cancer Institute · Buffalo, NY
- Stony Brook University Medical Center · Stony Brook, NY
- Roswell Park Amherst Center · Williamsville, NY
North Carolina · 1
- Margaret R Pardee Memorial Hospital · Hendersonville, NC
North Dakota · 1
- Essentia Health Cancer Center-South University Clinic · Fargo, ND
Ohio · 1
- Ohio State University Comprehensive Cancer Center · Columbus, OH
Oklahoma · 1
- University of Oklahoma Health Sciences Center · Oklahoma City, OK
Pennsylvania · 25
- Geisinger Medical Center · Danville, PA
- Geisinger Cancer Center Dickson City · Dickson City, PA
- Saint Vincent Hospital · Erie, PA
- UPMC Hillman Cancer Center Erie · Erie, PA
- UPMC Cancer Centers - Arnold Palmer Pavilion · Greensburg, PA
- UPMC Pinnacle Cancer Center/Community Osteopathic Campus · Harrisburg, PA
- Penn State Milton S Hershey Medical Center · Hershey, PA
- IRMC Cancer Center · Indiana, PA
- Jefferson Hospital · Jefferson Hills, PA
- Geisinger Medical Oncology-Lewisburg · Lewisburg, PA
- UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion · Mechanicsburg, PA
- Forbes Hospital · Monroeville, PA
- UPMC Hillman Cancer Center - Monroeville · Monroeville, PA
- Allegheny Valley Hospital · Natrona Heights, PA
- Allegheny General Hospital · Pittsburgh, PA
- UPMC Hillman Cancer Center · Pittsburgh, PA
- UPMC-Passavant Hospital · Pittsburgh, PA
- UPMC-Saint Margaret · Pittsburgh, PA
- West Penn Hospital · Pittsburgh, PA
- UPMC Cancer Center at UPMC Northwest · Seneca, PA
- UPMC Cancer Center-Uniontown · Uniontown, PA
- UPMC Cancer Center-Washington · Washington, PA
- Reading Hospital · West Reading, PA
- Wexford Health and Wellness Pavilion · Wexford, PA
- Geisinger Wyoming Valley/Henry Cancer Center · Wilkes-Barre, PA
South Dakota · 5
- Avera Cancer Institute-Aberdeen · Aberdeen, SD
- Avera Cancer Institute - Mitchell · Mitchell, SD
- Avera Cancer Institute at Pierre · Pierre, SD
- Avera Cancer Institute · Sioux Falls, SD
- Avera Cancer Institute at Yankton · Yankton, SD
Texas · 13
- Houston Methodist San Jacinto Hospital · Baytown, TX
- Houston Methodist Cypress Hospital · Cypress, TX
- Parkland Memorial Hospital · Dallas, TX
- UT Southwestern Simmons Cancer Center - RedBird · Dallas, TX
- UT Southwestern/Simmons Cancer Center-Dallas · Dallas, TX
- UT Southwestern/Simmons Cancer Center-Fort Worth · Fort Worth, TX
- Houston Methodist Hospital · Houston, TX
- Houston Methodist West Hospital · Houston, TX
- Methodist Willowbrook Hospital · Houston, TX
- Houston Methodist Saint John Hospital · Nassau Bay, TX
- UT Southwestern Clinical Center at Richardson/Plano · Richardson, TX
- Houston Methodist Sugar Land Hospital · Sugar Land, TX
- Houston Methodist The Woodlands Hospital · The Woodlands, TX
Vermont · 4
- Central Vermont Medical Center/National Life Cancer Treatment · Berlin Corners, VT
- University of Vermont and State Agricultural College · Burlington, VT
- University of Vermont Medical Center · Burlington, VT
- Dartmouth Cancer Center - North · Saint Johnsbury, VT
Virginia · 4
- Hematology Oncology Associates of Fredericksburg Inc · Fredericksburg, VA
- VCU Massey Cancer Center at Stony Point · Richmond, VA
- VCU Massey Comprehensive Cancer Center · Richmond, VA
- Virginia Cancer Institute · Richmond, VA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.