Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer
NCT06513962
This study is recruiting at 191 US sites in 41 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase III trial compares the effect of giving triptorelin vs no triptorelin in preventing ovarian damage in adolescents and young adults (AYAs) with cancer receiving chemotherapy with alkylating agents. Alkylating agents are part of standard chemotherapy, but may cause damage to the ovaries. If the ovaries are not working well or completely shut down, then it will be difficult or impossible to get pregnant in the future. Triptorelin works by blocking certain hormones and causing the ovaries to slow down or pause normal activity.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Hematopoietic and Lymphatic System Neoplasm
- Malignant Solid Neoplasm
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- Up to 39 years
- Sex
- Female
- Healthy volunteers
- Not accepted
- Sponsor
- Children's Oncology Group
- Last updated on ClinicalTrials.gov
- August 31, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 3
- Children's Hospital of Alabama · Birmingham, AL
- University of Alabama at Birmingham Cancer Center · Birmingham, AL
- USA Health Strada Patient Care Center · Mobile, AL
Arizona · 2
- Phoenix Childrens Hospital · Phoenix, AZ
- Banner University Medical Center - Tucson · Tucson, AZ
Arkansas · 3
- Mercy Hospital Fort Smith · Fort Smith, AR
- Arkansas Children's Hospital · Little Rock, AR
- CARTI Cancer Center · Little Rock, AR
California · 8
- City of Hope Comprehensive Cancer Center · Duarte, CA
- UC San Diego Moores Cancer Center · La Jolla, CA
- Loma Linda University Medical Center · Loma Linda, CA
- Mattel Children's Hospital UCLA · Los Angeles, CA
- Kaiser Permanente-Oakland · Oakland, CA
- Children's Hospital of Orange County · Orange, CA
- Sutter Medical Center Sacramento · Sacramento, CA
- Rady Children's Hospital - San Diego · San Diego, CA
Colorado · 2
- Children's Hospital Colorado · Aurora, CO
- Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center · Denver, CO
Connecticut · 1
- Connecticut Children's Medical Center · Hartford, CT
Delaware · 8
- Beebe Medical Center · Lewes, DE
- Beebe South Coastal Health Campus · Millville, DE
- Christiana Care Health System-Christiana Hospital · Newark, DE
- Helen F Graham Cancer Center · Newark, DE
- Medical Oncology Hematology Consultants PA · Newark, DE
- Beebe Health Campus · Rehoboth Beach, DE
- Alfred I duPont Hospital for Children · Wilmington, DE
- Christiana Care Health System-Wilmington Hospital · Wilmington, DE
District of Columbia · 1
- Children's National Medical Center · Washington D.C., DC
Florida · 12
- Golisano Children's Hospital of Southwest Florida · Fort Myers, FL
- UF Health Cancer Institute - Gainesville · Gainesville, FL
- Memorial Regional Hospital/Joe DiMaggio Children's Hospital · Hollywood, FL
- Nemours Children's Clinic-Jacksonville · Jacksonville, FL
- Miami Cancer Institute · Miami, FL
- Nicklaus Children's Hospital · Miami, FL
- University of Miami Miller School of Medicine-Sylvester Cancer Center · Miami, FL
- AdventHealth Orlando · Orlando, FL
- Nemours Children's Hospital · Orlando, FL
- Nemours Children's Clinic - Pensacola · Pensacola, FL
- Tampa General Hospital · Tampa, FL
- Saint Mary's Medical Center · West Palm Beach, FL
Georgia · 1
- Children's Healthcare of Atlanta - Arthur M Blank Hospital · Atlanta, GA
Hawaii · 1
- Kapiolani Medical Center for Women and Children · Honolulu, HI
Illinois · 19
- OSF Saint Anthony's Health Center · Alton, IL
- Lurie Children's Hospital-Chicago · Chicago, IL
- Northwestern University · Chicago, IL
- University of Illinois · Chicago, IL
- Northwestern Medicine Cancer Center Kishwaukee · DeKalb, IL
- Northwestern Medicine Cancer Center Delnor · Geneva, IL
- Northwestern Medicine Glenview Outpatient Center · Glenview, IL
- Northwestern Medicine Grayslake Outpatient Center · Grayslake, IL
- Northwestern Medicine Lake Forest Hospital · Lake Forest, IL
- SSM Health Good Samaritan · Mount Vernon, IL
- Carle BroMenn Medical Center · Normal, IL
- Carle Cancer Institute Normal · Normal, IL
- Advocate Children's Hospital-Oak Lawn · Oak Lawn, IL
- Northwestern Medicine Orland Park · Orland Park, IL
- Advocate Children's Hospital-Park Ridge · Park Ridge, IL
- Memorial Hospital East · Shiloh, IL
- Saint John's Hospital · Springfield, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Northwestern Medicine Cancer Center Warrenville · Warrenville, IL
Indiana · 2
- Indiana University/Melvin and Bren Simon Cancer Center · Indianapolis, IN
- Riley Hospital for Children · Indianapolis, IN
Iowa · 17
- UI Health Care Mission Cancer and Blood - Ankeny Clinic · Ankeny, IA
- Saint Anthony Regional Hospital · Carroll, IA
- Mercy Cancer Center-West Lakes · Clive, IA
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic · Clive, IA
- Greater Regional Medical Center · Creston, IA
- Blank Children's Hospital · Des Moines, IA
- Broadlawns Medical Center · Des Moines, IA
- Iowa Methodist Medical Center · Des Moines, IA
- Mercy Medical Center - Des Moines · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Des Moines Clinic · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Laurel Clinic · Des Moines, IA
- UI Healthcare Mission Cancer and Blood - Fort Dodge · Fort Dodge, IA
- University of Iowa/Holden Comprehensive Cancer Center · Iowa City, IA
- UI Healthcare Mission Cancer and Blood - Pella · Pella, IA
- UI Health Care Mission Cancer and Blood - Waukee Clinic · Waukee, IA
- Mercy Medical Center-West Lakes · West Des Moines, IA
- The Iowa Clinic PC · West Des Moines, IA
Kansas · 2
- Central Care Cancer Center - Garden City · Garden City, KS
- Central Care Cancer Center - Great Bend · Great Bend, KS
Kentucky · 1
- Norton Children's Hospital · Louisville, KY
Louisiana · 2
- Children's Hospital New Orleans · New Orleans, LA
- Ochsner Medical Center Jefferson · New Orleans, LA
Maine · 2
- Maine Children's Cancer Program · Scarborough, ME
- MaineHealth Maine Medical Center- Scarborough · Scarborough, ME
Maryland · 2
- Walter Reed National Military Medical Center · Bethesda, MD
- Christiana Care - Union Hospital · Elkton, MD
Michigan · 17
- C S Mott Children's Hospital · Ann Arbor, MI
- University of Michigan Rogel Cancer Center · Ann Arbor, MI
- Bronson Battle Creek · Battle Creek, MI
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital · Grand Rapids, MI
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital · Grand Rapids, MI
- Trinity Health Grand Rapids Hospital · Grand Rapids, MI
- Beacon Kalamazoo · Kalamazoo, MI
- Beacon Kalamazoo Cancer Center · Kalamazoo, MI
- Bronson Methodist Hospital · Kalamazoo, MI
- West Michigan Cancer Center · Kalamazoo, MI
- Trinity Health Muskegon Hospital · Muskegon, MI
- Corewell Health Lakeland Hospitals - Niles Hospital · Niles, MI
- Corewell Health Reed City Hospital · Reed City, MI
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center · Saint Joseph, MI
- Corewell Health Lakeland Hospitals - Saint Joseph Hospital · Saint Joseph, MI
- Munson Medical Center · Traverse City, MI
- University of Michigan Health - West · Wyoming, MI
Minnesota · 2
- Children's Hospitals and Clinics of Minnesota - Minneapolis · Minneapolis, MN
- University of Minnesota/Masonic Cancer Center · Minneapolis, MN
Mississippi · 1
- University of Mississippi Medical Center · Jackson, MS
Missouri · 22
- Mercy Oncology and Hematology - Clayton-Clarkson · Ballwin, MO
- Central Care Cancer Center - Bolivar · Bolivar, MO
- Cox Cancer Center Branson · Branson, MO
- Mercy Cancer Center - Cape Girardeau · Cape Girardeau, MO
- Siteman Cancer Center at Saint Peters Hospital · City of Saint Peters, MO
- Siteman Cancer Center at West County Hospital · Creve Coeur, MO
- Freeman Health System · Joplin, MO
- Mercy Hospital Joplin · Joplin, MO
- Children's Mercy Hospitals and Clinics · Kansas City, MO
- Lake Regional Hospital · Osage Beach, MO
- Mercy Clinic-Rolla-Cancer and Hematology · Rolla, MO
- Phelps Health Delbert Day Cancer Institute · Rolla, MO
- Heartland Regional Medical Center · Saint Joseph, MO
- CoxHealth South Hospital · Springfield, MO
- Mercy Hospital Springfield · Springfield, MO
- Mercy Hospital Saint Louis · St Louis, MO
- Mercy Hospital South · St Louis, MO
- Mercy Infusion Center - Chippewa · St Louis, MO
- Siteman Cancer Center at Christian Hospital · St Louis, MO
- Siteman Cancer Center-South County · St Louis, MO
- Washington University School of Medicine · St Louis, MO
- Mercy Hospital Washington · Washington, MO
Nebraska · 2
- Children's Hospital and Medical Center of Omaha · Omaha, NE
- University of Nebraska Medical Center · Omaha, NE
New Jersey · 1
- Hackensack University Medical Center · Hackensack, NJ
New Mexico · 2
- Presbyterian Hospital · Albuquerque, NM
- University of New Mexico Cancer Center · Albuquerque, NM
New York · 6
- Albany Medical Center · Albany, NY
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center · New York, NY
- NYP/Weill Cornell Medical Center · New York, NY
- University of Rochester · Rochester, NY
- Stony Brook University Medical Center · Stony Brook, NY
- Montefiore Medical Center - Moses Campus · The Bronx, NY
North Carolina · 3
- UNC Lineberger Comprehensive Cancer Center · Chapel Hill, NC
- Duke University Medical Center · Durham, NC
- Wake Forest University Health Sciences · Winston-Salem, NC
North Dakota · 2
- Sanford Bismarck Medical Center · Bismarck, ND
- Sanford Broadway Medical Center · Fargo, ND
Ohio · 3
- Children's Hospital Medical Center of Akron · Akron, OH
- Cleveland Clinic Foundation · Cleveland, OH
- Nationwide Children's Hospital · Columbus, OH
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.