A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
NCT06492616
This study is recruiting at 172 US sites in 41 states, according to its ClinicalTrials.gov record last updated .
Summary
The primary goal of this study is to evaluate the effectiveness of elacestrant versus standard endocrine therapy in participants with node-positive, Estrogen Receptor-positive (ER+), Human Epidermal Growth Factor-2 negative (HER2-) early breast cancer with high risk of recurrence.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Breast Cancer
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Stemline Therapeutics, Inc.
- Last updated on ClinicalTrials.gov
- September 15, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- Southern Cancer Center, PC · Daphne, AL
Arizona · 6
- Ironwood Cancer and Research Centers · Chandler, AZ
- Banner MD Anderson Cancer Center · Gilbert, AZ
- Banner University Medical Center - Phoenix Campus (Banner Good Samaritan Medical Center) · Phoenix, AZ
- Mayo Clinic · Scottsdale, AZ
- Arizona Clinical Research Center, Inc. · Tucson, AZ
- University of Arizona Cancer Center · Tucson, AZ
Arkansas · 1
- Highlands Oncology Group, PA · Springdale, AR
California · 22
- UCSF Cancer Center Berkeley · Berkeley, CA
- Cedars-Sinai Cancer Beverly Hills · Beverly Hills, CA
- City of Hope National Medical Center · Duarte, CA
- UCSF Wash Cancer CNTR · Fremont, CA
- City of Hope at Irvine Lennar · Irvine, CA
- UC San Diego Moores Cancer Center · La Jolla, CA
- Helios Clinical Research · Long Beach, CA
- Cancer and Blood Research Center, LLC · Los Alamitos, CA
- UCLA Department of Medicine - Hematology/Oncology · Los Angeles, CA
- USC/Norris Comprehensive Cancer Center · Los Angeles, CA
- Pacific Cancer Care - Oncology · Monterey, CA
- Hoag Memorial Hospital Presbyterian · Newport Beach, CA
- UC Irvine Health, Chao Family Comprehensive Cancer Center · Orange, CA
- Stanford Women's Cancer Center · Palo Alto, CA
- Dignity Health dba Health Research Institute · Sacramento, CA
- Sutter Institute for Medical Research · Sacramento, CA
- UCSF Zuckerberg SF General · San Francisco, CA
- University of California, San Francisco (UCSF) · San Francisco, CA
- Southern California Kaiser Medical Center-San Marcos Medical · San Marcos, CA
- UCSF Cancer Center San Mateo · San Mateo, CA
- Sansum Clinic · Solvang, CA
- Torrance Memorial Physician Network- Cancer Care · Torrance, CA
Colorado · 3
- St. Joseph Hospital-Cancer Centers of Colorado · Denver, CO
- Rocky Mountain Cancer Centers, LLP · Lone Tree, CO
- AHMG Hematology and Oncology · Parker, CO
Connecticut · 1
- Yale New Haven Hospital- Yale Cancer Center · New Haven, CT
District of Columbia · 4
- Georgetown University Medical Center · Washington D.C., DC
- MedStar Washington Hospital Center · Washington D.C., DC
- Sibley Memorial Hospital · Washington D.C., DC
- The George Washington Medical Faculty Associates · Washington D.C., DC
Florida · 15
- Florida Cancer Specialists · Fort Myers, FL
- Mayo Clinic · Jacksonville, FL
- Helios Clinical · Lakeland, FL
- Miami Cancer Institute at Baptist Health Inc. · Miami, FL
- University of Miami · Miami, FL
- AdventHealth Orlando Infusion Center · Orlando, FL
- Cancer Care Centers of Brevard (CCCB) - Palm Bay · Palm Bay, FL
- Memorial Healthcare System · Pembroke Pines, FL
- Ascension Sacred Heart · Pensacola, FL
- Miami Cancer Institute at Plantation · Plantation, FL
- Comprehensive Hematology Oncology · St. Petersburg, FL
- Florida Cancer Specialists · St. Petersburg, FL
- Moffitt Cancer Center · Tampa, FL
- Florida Cancer Specialists · West Palm Beach, FL
- Cleveland Clinic Florida · Weston, FL
Georgia · 3
- University Blood & Cancer Center, LLC · Athens, GA
- Northside Hospital · Atlanta, GA
- Winship Cancer Institute · Atlanta, GA
Hawaii · 1
- Kaiser Permanente Hawaii Moanalua Medical Center · Honolulu, HI
Illinois · 3
- Illinois Cancer Specialists · Arlington Heights, IL
- Northwestern Memorial Hospital · Chicago, IL
- RUSH MD Anderson Cancer Center · Chicago, IL
Indiana · 1
- Northwest Cancer Centers, PC · Dyer, IN
Iowa · 1
- Mission Cancer and Blood · Des Moines, IA
Kansas · 1
- Cancer Center of Kansas · Wichita, KS
Kentucky · 1
- UofL Health Brown Cancer Center · Louisville, KY
Louisiana · 1
- University Medical Center-New Orleans · New Orleans, LA
Maryland · 4
- Ascension St. Agnes Hospital · Baltimore, MD
- Mercy Medical Center · Baltimore, MD
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, MD
- Maryland Oncology Hematology, P.A. · Columbia, MD
Massachusetts · 11
- Beth Israel Deaconess Medical Center · Boston, MA
- Boston Medical Center · Boston, MA
- Dana Farber Cancer Institute · Boston, MA
- Massachusetts General Hospital · Boston, MA
- Mass General North Shore Cancer Center · Danvers, MA
- Dana Farber Cancer Institute at Foxborough · Foxborough, MA
- Dana Farber Cancer Institute - Merrimack Valley · Methuen, MA
- Dana-Farber Cancer Institute at Milford Regional · Milford, MA
- Mass General Cancer Center at Newton-Wellesley Hospital's Vernon Cancer Center · Newton, MA
- Dana-Farber/Brigham and Women's Cancer Center (DF/BWCC) in Clinical Affiliation with South Shore Hospital · South Weymouth, MA
- Mass General - North Shore Cancer Center · Waltham, MA
Michigan · 1
- The Cancer & Hematology Centers · Grand Rapids, MI
Minnesota · 5
- Mayo Clinic Health System - Albert Lea · Albert Lea, MN
- Mayo Clinic - Mankato · Mankato, MN
- Allina Health Cancer Institute - Abbott Northwestern Hospital · Minneapolis, MN
- Mayo Clinic · Rochester, MN
- Metro-MN Comm. Onc. Res Consortium · Saint Louis Park, MN
Mississippi · 1
- Baptist Clinical Research Institution · Oxford, MS
Missouri · 1
- Siteman Cancer Center · St Louis, MO
Nebraska · 3
- NHO Revive Research Institute LLC · Lincoln, NE
- Oncology Hematology West, PC dba Nebraska Cancer Specialists - Legacy · Omaha, NE
- University of Nebraska Medical Center · Omaha, NE
New Jersey · 4
- MD Anderson Cancer Center at Cooper · Camden, NJ
- Summit Medical Group · Florham Park, NJ
- John Theurer Ctr-Hackensack UMC · Hackensack, NJ
- Rutgers Cancer Institute · New Brunswick, NJ
New Mexico · 1
- Exigent Research LLC/New Mexico Oncology Hematology Consultants Ltd. · Albuquerque, NM
New York · 12
- Kings County Hospital Center · Brooklyn, NY
- Hematology Oncology Associates of Central New York, PC · East Syracuse, NY
- Cayuga Medical Center · Ithaca, NY
- NYU Langone Hospital-Long Island · Mineola, NY
- Columbia University Medical Center · New York, NY
- Icahn School of Medicine Mount Sinai · New York, NY
- Laura and Isaac Perlmutter Cancer Center/NYU Langone Health · New York, NY
- Mount Sinai West · New York, NY
- The Blavatnik Family - Chelsea Medical Center at Mount Sinai · New York, NY
- University of Rochester Medical · Rochester, NY
- Stony Brook University Cancer Center · Stony Brook, NY
- Clinical Research Alliance, Inc. · Westbury, NY
North Carolina · 3
- Duke Cancer Institute · Durham, NC
- Cape Fear Valley Medical Center · Fayetteville, NC
- Cone Health Cancer Center at Wesley Long · Greensboro, NC
Ohio · 4
- Miami Valley Hospital South · Centerville, OH
- Cleveland Clinic · Cleveland, OH
- MetroHealth · Cleveland, OH
- Oncology Hematology Care Clinical Trials, LLC · Fairfield, OH
Oklahoma · 1
- Oklahoma Cancer Specialists and Research Institute (OCSRI) - Tulsa Cancer Center · Tulsa, OK
Oregon · 4
- Providence Cancer Institute Franz Clinic · Portland, OR
- Providence Cancer Institute Franz Clinic · Portland, OR
- Oregon Oncology Specialists · Salem, OR
- Northwest Cancer Specialists, P.C. · Tigard, OR
Pennsylvania · 8
- Lehigh Valley Health Network - Cedar Crest · Allen, PA
- Consultants In Medical Oncology and Hematology, P.C. · Broomall, PA
- Penn State Milton S. Hershey Medical Center · Hershey, PA
- Holy Redeemer Hospital And Medical Center · Meadowbrook, PA
- Alliance Cancer Specialists, PC · Media, PA
- Fox Chase Cancer Center · Philadelphia, PA
- Lankenau Medical Center · Wynnewood, PA
- Cancer Care Associates of York, Inc. · York, PA
Rhode Island · 1
- Rhode Island Hospital · Providence, RI
South Carolina · 1
- Hollings Cancer Center · Charleston, SC
South Dakota · 2
- Avera St. Mary's Hospital · Pierre, SD
- Avera Cancer Institute · Sioux Falls, SD
Tennessee · 4
- Baptist Cancer Center · Memphis, TN
- Henry - Joyce Cancer Clinic · Nashville, TN
- SCRI Oncology Partners · Nashville, TN
- Tennessee Oncology, PLLC · Nashville, TN
Texas · 12
- Hendrick Cancer Center · Abilene, TX
- Texas Oncology-Northeast Texas · Allen, TX
- Texas Oncology - DFW · Dallas, TX
- Harris Health System - Smith Clinic · Houston, TX
- O'Quinn Medical Tower - McNair Campus · Houston, TX
- Oncology Consultants, P.A. · Houston, TX
- The University of Texas MD Anderson Cancer Center · Houston, TX
- Covenant Children's Hospital- Joe Arrington Cancer Research and Treatment Center · Lubbock, TX
- Texas Oncology - San Antonio · New Braunfels, TX
- Texas Oncology-Gulf Coast · Pearland, TX
- Mays Cancer Center · San Antonio, TX
- Texas Oncology- Central South · Weslaco, TX
Utah · 2
- Huntsman Cancer Institute, University of Utah · Salt Lake City, UT
- Utah Cancer Specialists · Salt Lake City, UT
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.