Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas
NCT06422806
This study is recruiting at 245 US sites in 35 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase III trial compares the effect of immunotherapy (pembrolizumab) plus chemotherapy (doxorubicin) to chemotherapy (doxorubicin) alone in treating patients with dedifferentiated liposarcoma (DDLPS), undifferentiated pleomorphic sarcoma (UPS) or a related poorly differentiated sarcoma that has spread from where it first started (primary site) to other places in the body (metastatic) or that cannot be removed by surgery (unresectable). Doxorubicin is in a class of medications called anthracyclines. Doxorubicin damages the cell's deoxyribonucleic acid (DNA) and may kill tumor cells.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Metastatic Dedifferentiated Liposarcoma
- Metastatic Undifferentiated Pleomorphic Sarcoma
- Stage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8
- Stage IV Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8
- Unresectable Dedifferentiated Liposarcoma
- Unresectable Undifferentiated Pleomorphic Sarcoma
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- National Cancer Institute (NCI)
- Last updated on ClinicalTrials.gov
- October 15, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 3
- Mayo Clinic Hospital in Arizona · Phoenix, AZ
- Banner University Medical Center - Tucson · Tucson, AZ
- University of Arizona Cancer Center-North Campus · Tucson, AZ
California · 29
- Kaiser Permanente Dublin · Dublin, CA
- Kaiser Permanente-Fremont · Fremont, CA
- Kaiser Permanente Fresno Orchard Plaza · Fresno, CA
- Kaiser Permanente-Fresno · Fresno, CA
- UC San Diego Moores Cancer Center · La Jolla, CA
- Cedars-Sinai Medical Center · Los Angeles, CA
- Keck Medicine of USC Koreatown · Los Angeles, CA
- Los Angeles General Medical Center · Los Angeles, CA
- USC / Norris Comprehensive Cancer Center · Los Angeles, CA
- Kaiser Permanente- Modesto MOB II · Modesto, CA
- Kaiser Permanente-Modesto · Modesto, CA
- USC Norris Oncology/Hematology-Newport Beach · Newport Beach, CA
- Kaiser Permanente-Oakland · Oakland, CA
- Stanford Cancer Institute Palo Alto · Palo Alto, CA
- VA Palo Alto Health Care System · Palo Alto, CA
- Huntington Memorial Hospital · Pasadena, CA
- Kaiser Permanente-Roseville · Roseville, CA
- Kaiser Permanente Downtown Commons · Sacramento, CA
- Kaiser Permanente-South Sacramento · Sacramento, CA
- Kaiser Permanente-San Francisco · San Francisco, CA
- UCSF Medical Center-Mission Bay · San Francisco, CA
- Kaiser Permanente-Santa Teresa-San Jose · San Jose, CA
- Kaiser Permanente San Leandro · San Leandro, CA
- Kaiser San Rafael-Gallinas · San Rafael, CA
- Kaiser Permanente Medical Center - Santa Clara · Santa Clara, CA
- Kaiser Permanente-Santa Rosa · Santa Rosa, CA
- Kaiser Permanente-South San Francisco · South San Francisco, CA
- Kaiser Permanente-Vallejo · Vallejo, CA
- Kaiser Permanente-Walnut Creek · Walnut Creek, CA
Colorado · 5
- UCHealth University of Colorado Hospital · Aurora, CO
- Cancer Care and Hematology-Fort Collins · Fort Collins, CO
- Poudre Valley Hospital · Fort Collins, CO
- UCHealth Greeley Hospital · Greeley, CO
- Medical Center of the Rockies · Loveland, CO
Connecticut · 10
- Smilow Cancer Hospital-Derby Care Center · Derby, CT
- Smilow Cancer Hospital Care Center-Fairfield · Fairfield, CT
- Smilow Cancer Hospital Care Center at Greenwich · Greenwich, CT
- Smilow Cancer Hospital Care Center - Guilford · Guilford, CT
- Yale University · New Haven, CT
- Smilow Cancer Hospital Care Center at Long Ridge · Stamford, CT
- Smilow Cancer Hospital-Torrington Care Center · Torrington, CT
- Smilow Cancer Hospital Care Center-Trumbull · Trumbull, CT
- Smilow Cancer Hospital-Waterbury Care Center · Waterbury, CT
- Smilow Cancer Hospital Care Center - Waterford · Waterford, CT
Delaware · 4
- Beebe South Coastal Health Campus · Millville, DE
- Helen F Graham Cancer Center · Newark, DE
- Medical Oncology Hematology Consultants PA · Newark, DE
- Beebe Health Campus · Rehoboth Beach, DE
Florida · 12
- UM Sylvester Comprehensive Cancer Center at Coral Gables · Coral Gables, FL
- UM Sylvester Comprehensive Cancer Center at Coral Springs · Coral Springs, FL
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach · Deerfield Beach, FL
- UF Health Cancer Institute - Gainesville · Gainesville, FL
- UM Sylvester Comprehensive Cancer Center at Hollywood · Hollywood, FL
- Mayo Clinic in Florida · Jacksonville, FL
- UM Sylvester Comprehensive Cancer Center at Kendall · Miami, FL
- University of Miami Miller School of Medicine-Sylvester Cancer Center · Miami, FL
- University of Miami Sylvester Comprehensive Cancer Center at Sole Mia · North Miami, FL
- UM Sylvester Comprehensive Cancer Center at Plantation · Plantation, FL
- Moffitt Cancer Center · Tampa, FL
- Moffitt Cancer Center - McKinley Campus · Tampa, FL
Georgia · 1
- Emory University Hospital Midtown · Atlanta, GA
Hawaii · 1
- Kaiser Permanente Moanalua Medical Center · Honolulu, HI
Idaho · 3
- Kootenai Health - Coeur d'Alene · Coeur d'Alene, ID
- Kootenai Clinic Cancer Services - Post Falls · Post Falls, ID
- Kootenai Clinic Cancer Services - Sandpoint · Sandpoint, ID
Illinois · 50
- Advocate Outpatient Center - Aurora · Aurora, IL
- Advocate Good Shepherd Hospital · Barrington, IL
- Illinois CancerCare-Bloomington · Bloomington, IL
- Illinois CancerCare-Canton · Canton, IL
- Illinois CancerCare-Carthage · Carthage, IL
- Centralia Oncology Clinic · Centralia, IL
- Advocate Illinois Masonic Medical Center · Chicago, IL
- Northwestern University · Chicago, IL
- University of Chicago Comprehensive Cancer Center · Chicago, IL
- University of Illinois · Chicago, IL
- AMG Crystal Lake - Oncology · Crystal Lake, IL
- Carle at The Riverfront · Danville, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Northwestern Medicine Cancer Center Kishwaukee · DeKalb, IL
- Illinois CancerCare-Dixon · Dixon, IL
- Advocate Good Samaritan Hospital · Downers Grove, IL
- Carle Physician Group-Effingham · Effingham, IL
- Crossroads Cancer Center · Effingham, IL
- Advocate Sherman Hospital · Elgin, IL
- Illinois CancerCare-Eureka · Eureka, IL
- Illinois CancerCare-Galesburg · Galesburg, IL
- Northwestern Medicine Cancer Center Delnor · Geneva, IL
- Northwestern Medicine Glenview Outpatient Center · Glenview, IL
- Northwestern Medicine Grayslake Outpatient Center · Grayslake, IL
- Ingalls Memorial Hospital · Harvey, IL
- Advocate South Suburban Hospital · Hazel Crest, IL
- Illinois CancerCare-Kewanee Clinic · Kewanee, IL
- Northwestern Medicine Lake Forest Hospital · Lake Forest, IL
- AMG Libertyville - Oncology · Libertyville, IL
- Condell Memorial Hospital · Libertyville, IL
- Illinois CancerCare-Macomb · Macomb, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- UC Comprehensive Cancer Center at Silver Cross · New Lenox, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- Advocate Christ Medical Center · Oak Lawn, IL
- Northwestern Medicine Orland Park · Orland Park, IL
- University of Chicago Medicine-Orland Park · Orland Park, IL
- Illinois CancerCare-Ottawa Clinic · Ottawa, IL
- Advocate Lutheran General Hospital · Park Ridge, IL
- Illinois CancerCare-Pekin · Pekin, IL
- Illinois CancerCare-Peoria · Peoria, IL
- Illinois CancerCare-Peru · Peru, IL
- Illinois CancerCare-Princeton · Princeton, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Springfield Clinic · Springfield, IL
- Springfield Memorial Hospital · Springfield, IL
- Carle Cancer Center · Urbana, IL
- Northwestern Medicine Cancer Center Warrenville · Warrenville, IL
- Illinois CancerCare - Washington · Washington, IL
Indiana · 3
- UChicago Medicine Northwest Indiana · Crown Point, IN
- Indiana University/Melvin and Bren Simon Cancer Center · Indianapolis, IN
- Sidney and Lois Eskenazi Hospital · Indianapolis, IN
Iowa · 9
- UI Health Care Mission Cancer and Blood - Ankeny Clinic · Ankeny, IA
- Saint Anthony Regional Hospital · Carroll, IA
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic · Clive, IA
- Broadlawns Medical Center · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Des Moines Clinic · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Laurel Clinic · Des Moines, IA
- UI Healthcare Mission Cancer and Blood - Fort Dodge · Fort Dodge, IA
- University of Iowa/Holden Comprehensive Cancer Center · Iowa City, IA
- UI Health Care Mission Cancer and Blood - Waukee Clinic · Waukee, IA
Kentucky · 2
- The James Graham Brown Cancer Center at University of Louisville · Louisville, KY
- UofL Health Medical Center Northeast · Louisville, KY
Massachusetts · 1
- Dana-Farber Cancer Institute · Boston, MA
Michigan · 8
- University of Michigan Rogel Cancer Center · Ann Arbor, MI
- Henry Ford Macomb Hospital-Clinton Township · Clinton Township, MI
- Henry Ford Medical Center-Fairlane · Dearborn, MI
- Henry Ford Hospital · Detroit, MI
- Allegiance Health · Jackson, MI
- Henry Ford Medical Center-Columbus · Novi, MI
- Henry Ford West Bloomfield Hospital · West Bloomfield, MI
- Henry Ford Wyandotte Hospital · Wyandotte, MI
Minnesota · 9
- Sanford Joe Lueken Cancer Center · Bemidji, MN
- Mercy Hospital · Coon Rapids, MN
- Essentia Health - Deer River Clinic · Deer River, MN
- Essentia Health Cancer Center · Duluth, MN
- Fairview Southdale Hospital · Edina, MN
- Essentia Health Hibbing Clinic · Hibbing, MN
- Saint John's Hospital - Healtheast · Maplewood, MN
- Abbott-Northwestern Hospital · Minneapolis, MN
- Mayo Clinic in Rochester · Rochester, MN
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.