Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]
NCT06422143
This study is recruiting at 16 US sites in 11 states, according to its ClinicalTrials.gov record last updated .
Summary
This is a phase 3 study of pembrolizumab in combination with carboplatin/taxane (paclitaxel or nab-paclitaxel) followed by pembrolizumab with or without maintenance sacituzumab tirumotecan (sac-TMT; MK-2870) in first-line treatment of metastatic squamous non-small cell lung cancer. It is hypothesized that pembrolizumab with maintenance sacituzumab tirumotecan is superior to pembrolizumab without sacituzumab tirumotecan maintenance with respect to overall survival (OS).
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Non-small Cell Lung Cancer
- NSCLC
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Merck Sharp & Dohme LLC
- Last updated on ClinicalTrials.gov
- October 15, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arkansas · 1
- CARTI Cancer Center ( Site 0006) · Little Rock, AR
California · 2
- Roy and Patricia Disney Family Cancer Center - Providence Saint Joseph Medical Center ( Site 0122) · Burbank, CA
- Sharp Memorial Hospital ( Site 9544) · San Diego, CA
Colorado · 2
- Intermountain Health Cancer Center Lutheran Hospital ( Site 0119) · Golden, CO
- Intermountain Health St. Mary's Regional Hospital ( Site 0116) · Grand Junction, CO
District of Columbia · 1
- Washington Hospital Center ( Site 0037) · Washington D.C., DC
Illinois · 1
- University of Chicago Medical Center ( Site 0145) · Chicago, IL
Michigan · 1
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor ( Site 9552) · Ypsilanti, MI
Minnesota · 1
- Allina Health Cancer Institute - Abbott Northwestern Hospital ( Site 0146) · Minneapolis, MN
New Jersey · 2
- John Theurer Cancer Center at Hackensack University Medical Center ( Site 0035) · Hackensack, NJ
- Capital Health Medical Center - Hopewell ( Site 0034) · Pennington, NJ
New Mexico · 1
- University of New Mexico Comprehensive Cancer Center ( Site 0135) · Albuquerque, NM
Pennsylvania · 2
- St Luke's University Health Network ( Site 0017) · Bethlehem, PA
- Thomas Jefferson University - Clinical Research Institute ( Site 0147) · Philadelphia, PA
Texas · 2
- Memorial Hermann Cancer Center ( Site 0015) · Houston, TX
- Oncology Consultants P.A. ( Site 0124) · Houston, TX
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.