Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer
NCT06343402
This study is recruiting at 23 US sites in 16 states, according to its ClinicalTrials.gov record last updated .
Summary
A first in human study to evaluate the safety and preliminary antitumor activity of BBO-8520, a KRAS G12C (ON and OFF) inhibitor, as a single agent and in combination with pembrolizumab and BBO-10203 in subjects with locally advanced and unresectable or metastatic non-small cell lung cancer with a KRAS (Kirsten rat sarcoma) G12C mutation.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Non-small Cell Lung Cancer
- Metastatic Non-Small Cell Lung Cancer
- NSCLC
- KRAS G12C
- Metastatic Lung Cancer
- Advanced Lung Carcinoma
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 1
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)
- Last updated on ClinicalTrials.gov
- September 3, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- O'Neal Comprehensive Cancer Center at UAB · Birmingham, AL
California · 3
- University of California - San Diego Moores Cancer Center · La Jolla, CA
- University of California San Francisco · San Francisco, CA
- UCLA Health - Santa Monica Cancer Care · Santa Monica, CA
Colorado · 1
- University of Colorado Cancer Center · Aurora, CO
Connecticut · 2
- Yale Cancer Center · New Haven, CT
- Norwalk Hospital · Norwalk, CT
Illinois · 1
- OSF Saint Francis Medical Center · Peoria, IL
Kansas · 1
- University of Kansas Medical Center · Kansas City, KS
Maryland · 1
- University of Maryland Marlene & Stewart Greenebaum Comprehensive Cancer Center · Baltimore, MD
Michigan · 1
- Henry Ford Cancer - Detroit · Detroit, MI
New York · 3
- Roswell Park Cancer Institute · Buffalo, NY
- Memorial Sloan Kettering Cancer Center · New York, NY
- Perlmutter Cancer Center - NYU Langone Health · New York, NY
Ohio · 1
- Cleveland Clinic · Cleveland, OH
Oregon · 1
- USOR - Oncology Associates of Oregon, P.C · Eugene, OR
Tennessee · 1
- SCRI Oncology Partners · Nashville, TN
Texas · 2
- Oncology Consultants Texas Medical Center · Houston, TX
- USOR - Texas Oncology - (DFW) Waco · Waco, TX
Utah · 1
- Huntsman Cancer Institute · Salt Lake City, UT
Virginia · 1
- NEXT Oncology · Fairfax, VA
Washington · 2
- Fred Hutchinson Cancer Center · Seattle, WA
- Northwest Medical Specialties · Tacoma, WA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.