Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden Follicular Lymphoma
NCT06337318
This study is recruiting at 262 US sites in 39 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase III trial compares the effectiveness of rituximab to mosunetuzumab in treating patients with follicular lymphoma with a low tumor burden. Rituximab is a monoclonal antibody. It binds to a protein called CD20, which is found on B cells (a type of white blood cell) and some types of cancer cells. This may help the immune system kill cancer cells. Mosunetuzumab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Classic Follicular Lymphoma
- Follicular Lymphoma With Unusual Cytological Features
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- National Cancer Institute (NCI)
- Last updated on ClinicalTrials.gov
- October 14, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- University of Alabama at Birmingham Cancer Center · Birmingham, AL
Arizona · 3
- Mayo Clinic Hospital in Arizona · Phoenix, AZ
- Banner University Medical Center - Tucson · Tucson, AZ
- University of Arizona Cancer Center-North Campus · Tucson, AZ
Arkansas · 4
- Highlands Oncology Group - Fayetteville · Fayetteville, AR
- University of Arkansas for Medical Sciences · Little Rock, AR
- Highlands Oncology Group - Rogers · Rogers, AR
- Highlands Oncology Group · Springdale, AR
California · 13
- Tower Cancer Research Foundation · Beverly Hills, CA
- City of Hope Comprehensive Cancer Center · Duarte, CA
- City of Hope at Irvine Lennar · Irvine, CA
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care · Irvine, CA
- City of Hope Antelope Valley · Lancaster, CA
- City of Hope at Long Beach Elm · Long Beach, CA
- Tibor Rubin VA Medical Center · Long Beach, CA
- Cedars-Sinai Medical Center · Los Angeles, CA
- UC Irvine Health/Chao Family Comprehensive Cancer Center · Orange, CA
- City of Hope South Pasadena · South Pasadena, CA
- Torrance Memorial Physician Network - Cancer Care · Torrance, CA
- City of Hope Upland · Upland, CA
- UCI Health - Yorba Linda · Yorba Linda, CA
Colorado · 5
- UCHealth University of Colorado Hospital · Aurora, CO
- Cancer Care and Hematology-Fort Collins · Fort Collins, CO
- Poudre Valley Hospital · Fort Collins, CO
- UCHealth Greeley Hospital · Greeley, CO
- Medical Center of the Rockies · Loveland, CO
Delaware · 2
- Helen F Graham Cancer Center · Newark, DE
- Medical Oncology Hematology Consultants PA · Newark, DE
District of Columbia · 2
- MedStar Georgetown University Hospital · Washington D.C., DC
- Sibley Memorial Hospital · Washington D.C., DC
Florida · 18
- UM Sylvester Comprehensive Cancer Center at Aventura · Aventura, FL
- UM Sylvester Comprehensive Cancer Center at Coral Gables · Coral Gables, FL
- UM Sylvester Comprehensive Cancer Center at Coral Springs · Coral Springs, FL
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach · Deerfield Beach, FL
- UM Sylvester Comprehensive Cancer Center at Doral · Doral, FL
- UM Sylvester Comprehensive Cancer Center at Hollywood · Hollywood, FL
- Mayo Clinic in Florida · Jacksonville, FL
- UM Sylvester Comprehensive Cancer Center at Kendall · Miami, FL
- University of Miami Miller School of Medicine-Sylvester Cancer Center · Miami, FL
- Mount Sinai Medical Center · Miami Beach, FL
- University of Miami Sylvester Comprehensive Cancer Center at Sole Mia · North Miami, FL
- Memorial Hospital West · Pembroke Pines, FL
- UM Sylvester Comprehensive Cancer Center at Plantation · Plantation, FL
- Moffitt Cancer Center at SouthShore · Ruskin, FL
- Moffitt Cancer Center · Tampa, FL
- Moffitt Cancer Center - McKinley Campus · Tampa, FL
- Moffitt Cancer Center-International Plaza · Tampa, FL
- Moffitt Cancer Center at Wesley Chapel · Wesley Chapel, FL
Georgia · 4
- Emory Saint Joseph's Hospital · Atlanta, GA
- Emory University Hospital Midtown · Atlanta, GA
- Emory University Hospital/Winship Cancer Institute · Atlanta, GA
- Augusta University Medical Center · Augusta, GA
Idaho · 6
- Saint Alphonsus Cancer Care Center-Boise · Boise, ID
- Saint Alphonsus Cancer Care Center-Caldwell · Caldwell, ID
- Kootenai Health - Coeur d'Alene · Coeur d'Alene, ID
- Saint Alphonsus Cancer Care Center-Nampa · Nampa, ID
- Kootenai Clinic Cancer Services - Post Falls · Post Falls, ID
- Kootenai Clinic Cancer Services - Sandpoint · Sandpoint, ID
Illinois · 22
- Swedish Covenant Hospital · Chicago, IL
- University of Chicago Comprehensive Cancer Center · Chicago, IL
- Carle at The Riverfront · Danville, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Carle Physician Group-Effingham · Effingham, IL
- Crossroads Cancer Center · Effingham, IL
- Elmhurst Memorial Hospital · Elmhurst, IL
- NorthShore University HealthSystem-Evanston Hospital · Evanston, IL
- NorthShore University HealthSystem-Glenbrook Hospital · Glenview, IL
- NorthShore University HealthSystem-Highland Park Hospital · Highland Park, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- Edward Hospital/Cancer Center · Naperville, IL
- UC Comprehensive Cancer Center at Silver Cross · New Lenox, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- University of Chicago Medicine-Orland Park · Orland Park, IL
- Edward Hospital/Cancer Center?Plainfield · Plainfield, IL
- Memorial Hospital East · Shiloh, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Springfield Clinic · Springfield, IL
- Springfield Memorial Hospital · Springfield, IL
- Carle Cancer Center · Urbana, IL
Indiana · 10
- Northwest Cancer Center - Crown Point · Crown Point, IN
- UChicago Medicine Northwest Indiana · Crown Point, IN
- Northwest Oncology LLC · Dyer, IN
- Northwest Cancer Center - Hobart · Hobart, IN
- Saint Mary Medical Center · Hobart, IN
- Indiana University/Melvin and Bren Simon Cancer Center · Indianapolis, IN
- Saint Catherine Hospital · Indianapolis, IN
- The Community Hospital · Munster, IN
- Women's Diagnostic Center - Munster · Munster, IN
- Northwest Cancer Center - Valparaiso · Valparaiso, IN
Iowa · 14
- Mary Greeley Medical Center · Ames, IA
- McFarland Clinic - Ames · Ames, IA
- UI Health Care Mission Cancer and Blood - Ankeny Clinic · Ankeny, IA
- University of Iowa Healthcare Cancer Services Quad Cities · Bettendorf, IA
- Mercy Hospital · Cedar Rapids, IA
- Oncology Associates at Mercy Medical Center · Cedar Rapids, IA
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic · Clive, IA
- Iowa Methodist Medical Center · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Des Moines Clinic · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Laurel Clinic · Des Moines, IA
- McFarland Clinic - Trinity Cancer Center · Fort Dodge, IA
- University of Iowa/Holden Comprehensive Cancer Center · Iowa City, IA
- McFarland Clinic - Marshalltown · Marshalltown, IA
- UI Health Care Mission Cancer and Blood - Waukee Clinic · Waukee, IA
Kansas · 8
- HaysMed · Hays, KS
- University of Kansas Cancer Center · Kansas City, KS
- Lawrence Memorial Hospital · Lawrence, KS
- The University of Kansas Cancer Center - Olathe · Olathe, KS
- University of Kansas Cancer Center-Overland Park · Overland Park, KS
- Salina Regional Health Center · Salina, KS
- University of Kansas Health System Saint Francis Campus · Topeka, KS
- University of Kansas Hospital-Westwood Cancer Center · Westwood, KS
Louisiana · 2
- LSU Health Baton Rouge-North Clinic · Baton Rouge, LA
- Our Lady of the Lake Physician Group · Baton Rouge, LA
Maryland · 2
- Johns Hopkins University/Sidney Kimmel Cancer Center · Baltimore, MD
- Walter Reed National Military Medical Center · Bethesda, MD
Michigan · 34
- University of Michigan Rogel Cancer Center · Ann Arbor, MI
- Bronson Battle Creek · Battle Creek, MI
- Trinity Health IHA Medical Group Hematology Oncology - Brighton · Brighton, MI
- Trinity Health IHA Medical Group Hematology Oncology - Canton · Canton, MI
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital · Chelsea, MI
- Henry Ford Macomb Hospital-Clinton Township · Clinton Township, MI
- Henry Ford Medical Center-Fairlane · Dearborn, MI
- Henry Ford Hospital · Detroit, MI
- Wayne State University/Karmanos Cancer Institute · Detroit, MI
- OSF Saint Francis Hospital and Medical Group · Escanaba, MI
- Weisberg Cancer Treatment Center · Farmington Hills, MI
- Cancer Hematology Centers - Flint · Flint, MI
- Genesys Hurley Cancer Institute · Flint, MI
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital · Grand Rapids, MI
- Trinity Health Grand Rapids Hospital · Grand Rapids, MI
- Allegiance Health · Jackson, MI
- Bronson Methodist Hospital · Kalamazoo, MI
- West Michigan Cancer Center · Kalamazoo, MI
- University of Michigan Health - Sparrow Lansing · Lansing, MI
- Trinity Health Saint Mary Mercy Livonia Hospital · Livonia, MI
- Schoolcraft Memorial Hospital · Manistique, MI
- Trinity Health Muskegon Hospital · Muskegon, MI
- Corewell Health Lakeland Hospitals - Niles Hospital · Niles, MI
- Cancer and Hematology Centers of Western Michigan - Norton Shores · Norton Shores, MI
- Henry Ford Medical Center-Columbus · Novi, MI
- Trinity Health Saint Joseph Mercy Oakland Hospital · Pontiac, MI
- Corewell Health Reed City Hospital · Reed City, MI
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center · Saint Joseph, MI
- Corewell Health Lakeland Hospitals - Saint Joseph Hospital · Saint Joseph, MI
- Munson Medical Center · Traverse City, MI
- Henry Ford West Bloomfield Hospital · West Bloomfield, MI
- Henry Ford Wyandotte Hospital · Wyandotte, MI
- University of Michigan Health - West · Wyoming, MI
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus · Ypsilanti, MI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.