Venetoclax and HMA Treatment of Older and Unfit Adults With FLT3 Mutated Acute Myeloid Leukemia (AML) (A MyeloMATCH Treatment Trial)
NCT06317649
This study is recruiting at 211 US sites in 41 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase II MyeloMATCH treatment trial compares the usual treatment of azacitidine and venetoclax to the combination treatment of azacitidine, venetoclax and gilteritinib in treating older and unfit patients with acute myeloid leukemia and FLT3 mutations. Azacitidine is a drug that is absorbed into DNA and leads to the activation of cancer suppressor genes, which are genes that help control cell growth. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Acute Myeloid Leukemia
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- National Cancer Institute (NCI)
- Last updated on ClinicalTrials.gov
- October 14, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- University of Alabama at Birmingham Cancer Center · Birmingham, AL
Arizona · 2
- Banner University Medical Center - Tucson · Tucson, AZ
- University of Arizona Cancer Center-North Campus · Tucson, AZ
Arkansas · 1
- University of Arkansas for Medical Sciences · Little Rock, AR
California · 20
- Kaiser Permanente Dublin · Dublin, CA
- Kaiser Permanente-Fremont · Fremont, CA
- Kaiser Permanente Fresno Orchard Plaza · Fresno, CA
- Cedars-Sinai Medical Center · Los Angeles, CA
- Kaiser Permanente- Modesto MOB II · Modesto, CA
- Kaiser Permanente-Oakland · Oakland, CA
- Kaiser Permanente-Roseville · Roseville, CA
- Kaiser Permanente Downtown Commons · Sacramento, CA
- Kaiser Permanente-South Sacramento · Sacramento, CA
- University of California Davis Comprehensive Cancer Center · Sacramento, CA
- Kaiser Permanente-San Francisco · San Francisco, CA
- UCSF Medical Center-Parnassus · San Francisco, CA
- Kaiser Permanente-Santa Teresa-San Jose · San Jose, CA
- Kaiser Permanente San Leandro · San Leandro, CA
- Kaiser San Rafael-Gallinas · San Rafael, CA
- Kaiser Permanente Medical Center - Santa Clara · Santa Clara, CA
- Kaiser Permanente-Santa Rosa · Santa Rosa, CA
- Kaiser Permanente-South San Francisco · South San Francisco, CA
- Kaiser Permanente-Vallejo · Vallejo, CA
- Kaiser Permanente-Walnut Creek · Walnut Creek, CA
Connecticut · 2
- Yale University · New Haven, CT
- Veterans Affairs Connecticut Healthcare System-West Haven Campus · West Haven, CT
Florida · 2
- UF Health Cancer Institute - Gainesville · Gainesville, FL
- Miami Cancer Institute · Miami, FL
Georgia · 2
- Phoebe Putney Memorial Hospital · Albany, GA
- Augusta University Medical Center · Augusta, GA
Hawaii · 5
- Hawaii Cancer Care - Westridge · ‘Aiea, HI
- Pali Momi Medical Center · ‘Aiea, HI
- Hawaii Cancer Care Inc - Waterfront Plaza · Honolulu, HI
- Kaiser Permanente Moanalua Medical Center · Honolulu, HI
- Straub Clinic and Hospital · Honolulu, HI
Idaho · 10
- Saint Alphonsus Cancer Care Center-Boise · Boise, ID
- Saint Luke's Cancer Institute - Boise · Boise, ID
- Saint Alphonsus Cancer Care Center-Caldwell · Caldwell, ID
- Kootenai Health - Coeur d'Alene · Coeur d'Alene, ID
- Saint Luke's Cancer Institute - Fruitland · Fruitland, ID
- Saint Luke's Cancer Institute - Meridian · Meridian, ID
- Saint Alphonsus Cancer Care Center-Nampa · Nampa, ID
- Saint Luke's Cancer Institute - Nampa · Nampa, ID
- Kootenai Clinic Cancer Services - Post Falls · Post Falls, ID
- Kootenai Clinic Cancer Services - Sandpoint · Sandpoint, ID
Illinois · 29
- Northwestern University · Chicago, IL
- University of Chicago Comprehensive Cancer Center · Chicago, IL
- University of Illinois · Chicago, IL
- Carle at The Riverfront · Danville, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Northwestern Medicine Cancer Center Kishwaukee · DeKalb, IL
- Carle Physician Group-Effingham · Effingham, IL
- Crossroads Cancer Center · Effingham, IL
- NorthShore University HealthSystem-Evanston Hospital · Evanston, IL
- Northwestern Medicine Cancer Center Delnor · Geneva, IL
- NorthShore University HealthSystem-Glenbrook Hospital · Glenview, IL
- Northwestern Medicine Glenview Outpatient Center · Glenview, IL
- Northwestern Medicine Grayslake Outpatient Center · Grayslake, IL
- NorthShore University HealthSystem-Highland Park Hospital · Highland Park, IL
- Edward Hines Jr VA Hospital · Hines, IL
- Northwestern Medicine Lake Forest Hospital · Lake Forest, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- Loyola University Medical Center · Maywood, IL
- UC Comprehensive Cancer Center at Silver Cross · New Lenox, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- Northwestern Medicine Orland Park · Orland Park, IL
- University of Chicago Medicine-Orland Park · Orland Park, IL
- Memorial Hospital East · Shiloh, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Springfield Clinic · Springfield, IL
- Springfield Memorial Hospital · Springfield, IL
- Carle Cancer Center · Urbana, IL
- Northwestern Medicine Cancer Center Warrenville · Warrenville, IL
Indiana · 2
- UChicago Medicine Northwest Indiana · Crown Point, IN
- Indiana University/Melvin and Bren Simon Cancer Center · Indianapolis, IN
Iowa · 1
- University of Iowa/Holden Comprehensive Cancer Center · Iowa City, IA
Kansas · 5
- University of Kansas Clinical Research Center · Fairway, KS
- University of Kansas Cancer Center · Kansas City, KS
- University of Kansas Hospital-Indian Creek Campus · Overland Park, KS
- Cotton O'Neil Cancer Center / Stormont Vail Health · Topeka, KS
- University of Kansas Hospital-Westwood Cancer Center · Westwood, KS
Kentucky · 3
- University of Kentucky/Markey Cancer Center · Lexington, KY
- The James Graham Brown Cancer Center at University of Louisville · Louisville, KY
- UofL Health Medical Center Northeast · Louisville, KY
Louisiana · 3
- LSU Health Baton Rouge-North Clinic · Baton Rouge, LA
- Our Lady of The Lake · Baton Rouge, LA
- Our Lady of the Lake Physician Group · Baton Rouge, LA
Maine · 5
- MaineHealth Cancer Care and IV Therapy - Brunswick · Brunswick, ME
- Mid Coast Hospital · Brunswick, ME
- MaineHealth Maine Medical Center - Portland · Portland, ME
- MaineHealth Maine Medical Center- Scarborough · Scarborough, ME
- MaineHealth Cancer Care and IV Therapy - South Portland · South Portland, ME
Maryland · 1
- Walter Reed National Military Medical Center · Bethesda, MD
Massachusetts · 5
- Beth Israel Deaconess Medical Center · Boston, MA
- Dana-Farber Cancer Institute · Boston, MA
- Tufts Medical Center · Boston, MA
- Lahey Clinic · Burlington, MA
- Lahey Clinic Peabody · Peabody, MA
Michigan · 9
- Trinity Health IHA Medical Group Hematology Oncology - Brighton · Brighton, MI
- Trinity Health IHA Medical Group Hematology Oncology - Canton · Canton, MI
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital · Chelsea, MI
- Cancer Hematology Centers - Flint · Flint, MI
- Genesys Hurley Cancer Institute · Flint, MI
- Hurley Medical Center · Flint, MI
- Trinity Health Saint Mary Mercy Livonia Hospital · Livonia, MI
- Trinity Health Saint Joseph Mercy Oakland Hospital · Pontiac, MI
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus · Ypsilanti, MI
Minnesota · 11
- Mercy Hospital · Coon Rapids, MN
- Essentia Health - Deer River Clinic · Deer River, MN
- Essentia Health Cancer Center · Duluth, MN
- Fairview Southdale Hospital · Edina, MN
- Essentia Health Hibbing Clinic · Hibbing, MN
- Abbott-Northwestern Hospital · Minneapolis, MN
- Park Nicollet Clinic - Saint Louis Park · Saint Louis Park, MN
- Regions Hospital · Saint Paul, MN
- United Hospital · Saint Paul, MN
- Essentia Health Sandstone · Sandstone, MN
- Essentia Health Virginia Clinic · Virginia, MN
Mississippi · 5
- Baptist Memorial Hospital and Cancer Center-Golden Triangle · Columbus, MS
- Baptist Cancer Center-Grenada · Grenada, MS
- Baptist Memorial Hospital and Cancer Center-Union County · New Albany, MS
- Baptist Memorial Hospital and Cancer Center-Oxford · Oxford, MS
- Baptist Memorial Hospital and Cancer Center-Desoto · Southhaven, MS
Missouri · 5
- Siteman Cancer Center at Saint Peters Hospital · City of Saint Peters, MO
- Siteman Cancer Center at West County Hospital · Creve Coeur, MO
- Siteman Cancer Center at Christian Hospital · St Louis, MO
- Siteman Cancer Center-South County · St Louis, MO
- Washington University School of Medicine · St Louis, MO
Montana · 6
- Community Hospital of Anaconda · Anaconda, MT
- Billings Clinic Cancer Center · Billings, MT
- Bozeman Health Deaconess Hospital · Bozeman, MT
- Benefis Sletten Cancer Institute · Great Falls, MT
- Logan Health Medical Center · Kalispell, MT
- Community Medical Center · Missoula, MT
New Hampshire · 1
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center · Lebanon, NH
New Jersey · 9
- Memorial Sloan Kettering Basking Ridge · Basking Ridge, NJ
- Cooperman Barnabas Medical Center · Livingston, NJ
- Monmouth Medical Center · Long Branch, NJ
- Memorial Sloan Kettering Monmouth · Middletown, NJ
- Memorial Sloan Kettering Bergen · Montvale, NJ
- Rutgers Cancer Institute of New Jersey · New Brunswick, NJ
- The Valley Hospital - Luckow Pavilion · Paramus, NJ
- Valley Health System Ridgewood Campus · Ridgewood, NJ
- Community Medical Center · Toms River, NJ
New Mexico · 1
- University of New Mexico Cancer Center · Albuquerque, NM
New York · 4
- Roswell Park Cancer Institute · Buffalo, NY
- Memorial Sloan Kettering Commack · Commack, NY
- Northwell Health/Center for Advanced Medicine · Lake Success, NY
- North Shore University Hospital · Manhasset, NY
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.