Deep Brain Stimulation for Psychosis

Summary

There are three hypotheses proposed for this study: 1) Participants will report no unanticipated serious adverse events during the eight months of treatment. 2) Investigators will successfully model psychotic versus non-psychotic brain states using support vector machine (SVM) classifiers. 3) Participants specific brain stimulation parameters can induce a change in the brain state consistent with non-psychotic states as measured by classifier output. Hypotheses 1, 2, and 3 address safety and tolerability, efficacy, and the putative mechanism of successful treatment.

Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov

Conditions studied

• Treatment-Refractory Schizophrenia

Eligibility basics and study details

Study type

Interventional

Phase

Not applicable

Ages

22 to 70 years

Sex

All

Healthy volunteers

Not accepted

Sponsor

Bradley Lega

Last updated on ClinicalTrials.gov

June 9, 2026

These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.

US recruiting sites