A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors
NCT06244771
This study is recruiting at 12 US sites in 9 states, according to its ClinicalTrials.gov record last updated .
Summary
The goal of this clinical trial is to evaluate FMC-376 in participants with advanced solid tumors with KRAS G12C mutations. This clinical trial will be conducted in 3 parts: Phase 1A (Dose Escalation), Phase 1B (Dose Expansion), and Phase 2 (Cohort Expansion). Multiple dose levels in participants with advanced solid tumors will be evaluated.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Advanced Solid Tumors With KRAS G12C Mutations
- Solid Tumor, Adult
- Unresectable Solid Tumor
- Metastatic Solid Tumor
- Non Small Cell Lung Cancer
- Colorectal Cancer
- KRAS G12C
- Pancreatic Cancer
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 1/2
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Frontier Medicines Corporation
- Last updated on ClinicalTrials.gov
- March 18, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
California · 2
- University of California San Diego (UC San Diego) Health - Jacobs Medical Center - Moores Cancer Center · La Jolla, CA
- University of California San Francisco (UCSF) - Helen Diller Family Comprehensive Cancer Center · San Francisco, CA
Indiana · 1
- Northwest Cancer Centers · Dyer, IN
Kansas · 1
- The University of Kansas Cancer Center · Fairway, KS
Massachusetts · 1
- Dana-Farber Cancer Institute · Boston, MA
Michigan · 1
- Karmanos Cancer Institute · Detroit, MI
Pennsylvania · 1
- University of Pennsylvania · Philadelphia, PA
Texas · 3
- The University of Texas MD Anderson Cancer Center · Houston, TX
- South Texas Accelerated Research Therapeutics, LLC · San Antonio, TX
- UT Health San Antonio · San Antonio, TX
Utah · 1
- START Mountain Region · West Valley City, UT
Virginia · 1
- Virginia Cancer Specialists · Fairfax, VA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.