Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer
NCT06205485
This study is recruiting at 102 US sites in 27 states, according to its ClinicalTrials.gov record last updated .
Summary
This study is being done to answer the following questions: Is the chance of rectal cancer responding the same if chemotherapy alone is given before limited surgery compared to chemotherapy and radiation therapy given together before limited surgery? If radiation therapy is not given, is quality of life better?
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Rectal Cancer
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Canadian Cancer Trials Group
- Last updated on ClinicalTrials.gov
- July 14, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 1
- Cancer Center at Saint Joseph's · Phoenix, AZ
California · 5
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care · Irvine, CA
- Los Angeles General Medical Center · Los Angeles, CA
- USC / Norris Comprehensive Cancer Center · Los Angeles, CA
- UC Irvine Health/Chao Family Comprehensive Cancer Center · Orange, CA
- Mission Hope Medical Oncology - Santa Maria · Santa Maria, CA
Delaware · 4
- Beebe South Coastal Health Campus · Millville, DE
- Helen F Graham Cancer Center · Newark, DE
- Medical Oncology Hematology Consultants PA · Newark, DE
- Beebe Health Campus · Rehoboth Beach, DE
Georgia · 3
- Emory Saint Joseph's Hospital · Atlanta, GA
- Emory University Hospital Midtown · Atlanta, GA
- Emory University Hospital/Winship Cancer Institute · Atlanta, GA
Illinois · 9
- Rush-Copley Medical Center · Aurora, IL
- Northwestern University · Chicago, IL
- Carle at The Riverfront · Danville, IL
- Northwestern Medicine Cancer Center Kishwaukee · DeKalb, IL
- Carle Physician Group-Effingham · Effingham, IL
- Northwestern Medicine Cancer Center Delnor · Geneva, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- Carle Cancer Center · Urbana, IL
- Northwestern Medicine Cancer Center Warrenville · Warrenville, IL
Indiana · 6
- Northwest Cancer Center - Crown Point · Crown Point, IN
- Northwest Oncology LLC · Dyer, IN
- Northwest Cancer Center - Hobart · Hobart, IN
- Saint Mary Medical Center · Hobart, IN
- The Community Hospital · Munster, IN
- Northwest Cancer Center - Valparaiso · Valparaiso, IN
Louisiana · 3
- Ochsner Hematology Oncology North Shore - Covington (West Region) · Covington, LA
- Ochsner Medical Center Jefferson · New Orleans, LA
- University Medical Center New Orleans · New Orleans, LA
Massachusetts · 3
- Beverly Hospital · Beverly, MA
- Lahey Clinic · Burlington, MA
- Addison Gilbert Hospital · Gloucester, MA
Michigan · 9
- Henry Ford Macomb Hospital-Clinton Township · Clinton Township, MI
- Henry Ford Medical Center-Fairlane · Dearborn, MI
- Henry Ford Hospital · Detroit, MI
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital · Grand Rapids, MI
- Allegiance Health · Jackson, MI
- West Michigan Cancer Center · Kalamazoo, MI
- Henry Ford Medical Center-Columbus · Novi, MI
- Henry Ford West Bloomfield Hospital · West Bloomfield, MI
- Henry Ford Wyandotte Hospital · Wyandotte, MI
Minnesota · 1
- Sanford Joe Lueken Cancer Center · Bemidji, MN
Missouri · 1
- Mercy Hospital Saint Louis · St Louis, MO
Nevada · 1
- Renown Regional Medical Center · Reno, NV
New Hampshire · 1
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center · Lebanon, NH
New Jersey · 3
- Memorial Sloan Kettering Basking Ridge · Basking Ridge, NJ
- Memorial Sloan Kettering Monmouth · Middletown, NJ
- Memorial Sloan Kettering Bergen · Montvale, NJ
New Mexico · 1
- University of New Mexico Cancer Center · Albuquerque, NM
New York · 7
- Roswell Park Cancer Institute · Buffalo, NY
- Memorial Sloan Kettering Commack · Commack, NY
- Memorial Sloan Kettering Westchester · Harrison, NY
- Memorial Sloan Kettering Cancer Center · New York, NY
- University of Rochester · Rochester, NY
- Memorial Sloan Kettering Nassau · Uniondale, NY
- Wilmot Cancer Institute at Webster · Webster, NY
North Carolina · 1
- East Carolina University · Greenville, NC
North Dakota · 3
- Sanford Bismarck Medical Center · Bismarck, ND
- Sanford Broadway Medical Center · Fargo, ND
- Sanford Roger Maris Cancer Center · Fargo, ND
Ohio · 9
- Miami Valley Hospital South · Centerville, OH
- University of Cincinnati Cancer Center-UC Medical Center · Cincinnati, OH
- Ohio State University Comprehensive Cancer Center · Columbus, OH
- Miami Valley Hospital North · Dayton, OH
- Premier Blood and Cancer Center · Dayton, OH
- Atrium Medical Center-Middletown Regional Hospital · Franklin, OH
- Miami Valley Cancer Care and Infusion · Greenville, OH
- Upper Valley Medical Center · Troy, OH
- University of Cincinnati Cancer Center-West Chester · West Chester, OH
Oregon · 9
- Clackamas Radiation Oncology Center · Clackamas, OR
- Legacy Mount Hood Medical Center · Gresham, OR
- Providence Newberg Medical Center · Newberg, OR
- Providence Willamette Falls Medical Center · Oregon City, OR
- Legacy Good Samaritan Hospital and Medical Center · Portland, OR
- Oregon Health and Science University · Portland, OR
- Providence Portland Medical Center · Portland, OR
- Providence Saint Vincent Medical Center · Portland, OR
- Legacy Meridian Park Hospital · Tualatin, OR
Pennsylvania · 2
- Christiana Care Health System-Concord Health Center · Chadds Ford, PA
- Penn State Milton S Hershey Medical Center · Hershey, PA
South Dakota · 2
- Sanford Cancer Center Oncology Clinic · Sioux Falls, SD
- Sanford USD Medical Center - Sioux Falls · Sioux Falls, SD
Tennessee · 2
- The West Clinic - Wolf River · Germantown, TN
- Vanderbilt University/Ingram Cancer Center · Nashville, TN
Texas · 2
- UT MD Anderson Cancer Center · Houston, TX
- Scott and White Memorial Hospital · Temple, TX
Vermont · 1
- Dartmouth Cancer Center - North · Saint Johnsbury, VT
Washington · 7
- FHCC Overlake · Bellevue, WA
- FHCC at EvergreenHealth · Kirkland, WA
- FHCC at Northwest Hospital · Seattle, WA
- Fred Hutchinson Cancer Center · Seattle, WA
- Virginia Mason Medical Center · Seattle, WA
- Legacy Cancer Institute Medical Oncology and Day Treatment · Vancouver, WA
- Legacy Salmon Creek Hospital · Vancouver, WA
Wisconsin · 6
- Marshfield Medical Center-EC Cancer Center · Eau Claire, WI
- Marshfield Medical Center-Marshfield · Marshfield, WI
- Marshfield Medical Center - Minocqua · Minocqua, WI
- Marshfield Medical Center-Rice Lake · Rice Lake, WI
- Marshfield Medical Center-River Region at Stevens Point · Stevens Point, WI
- Marshfield Medical Center - Weston · Weston, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.