Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAMUNE Trial
NCT06203600
This study is recruiting at 330 US sites in 38 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase II/III trial compares the addition of nivolumab to the usual treatment of paclitaxel and ramucirumab to paclitaxel and ramucirumab alone in treating patients with gastric or esophageal adenocarcinoma that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). A monoclonal antibody is a type of protein that can bind to certain targets in the body, such as molecules that cause the body to make an immune response (antigens).
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Advanced Esophageal Adenocarcinoma
- Advanced Gastric Adenocarcinoma
- Advanced Gastroesophageal Junction Adenocarcinoma
- Clinical Stage II Esophageal Adenocarcinoma AJCC v8
- Clinical Stage III Esophageal Adenocarcinoma AJCC v8
- Clinical Stage III Gastric Cancer AJCC v8
- Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8
- Clinical Stage IV Esophageal Adenocarcinoma AJCC v8
- Clinical Stage IV Gastric Cancer AJCC v8
- Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8
- Metastatic Esophageal Adenocarcinoma
- Metastatic Gastric Adenocarcinoma
- Metastatic Gastroesophageal Junction Adenocarcinoma
- Unresectable Esophageal Adenocarcinoma
- Unresectable Gastric Adenocarcinoma
- Unresectable Gastroesophageal Junction Adenocarcinoma
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2/3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- National Cancer Institute (NCI)
- Last updated on ClinicalTrials.gov
- October 15, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arkansas · 2
- Baptist Health Medical Center - Little Rock · Little Rock, AR
- University of Arkansas for Medical Sciences · Little Rock, AR
California · 40
- Kaiser Permanente-Anaheim · Anaheim, CA
- Kaiser Permanente-Baldwin Park · Baldwin Park, CA
- Kaiser Permanente-Bellflower · Bellflower, CA
- Tower Cancer Research Foundation · Beverly Hills, CA
- Kaiser Permanente Dublin · Dublin, CA
- Kaiser Permanente-Fontana · Fontana, CA
- Kaiser Permanente-Fremont · Fremont, CA
- Kaiser Permanente Fresno Orchard Plaza · Fresno, CA
- Kaiser Permanente-Fresno · Fresno, CA
- Kaiser Permanente South Bay · Harbor City, CA
- Kaiser Permanente-Irvine · Irvine, CA
- UC San Diego Moores Cancer Center · La Jolla, CA
- Cedars-Sinai Medical Center · Los Angeles, CA
- Kaiser Permanente Los Angeles Medical Center · Los Angeles, CA
- Kaiser Permanente West Los Angeles · Los Angeles, CA
- Keck Medicine of USC Koreatown · Los Angeles, CA
- Los Angeles General Medical Center · Los Angeles, CA
- USC / Norris Comprehensive Cancer Center · Los Angeles, CA
- Kaiser Permanente- Modesto MOB II · Modesto, CA
- Kaiser Permanente-Modesto · Modesto, CA
- USC Norris Oncology/Hematology-Newport Beach · Newport Beach, CA
- Kaiser Permanente-Oakland · Oakland, CA
- Kaiser Permanente-Ontario · Ontario, CA
- Kaiser Permanente - Panorama City · Panorama City, CA
- Kaiser Permanente-Riverside · Riverside, CA
- Kaiser Permanente-Roseville · Roseville, CA
- Kaiser Permanente Downtown Commons · Sacramento, CA
- Kaiser Permanente-South Sacramento · Sacramento, CA
- Kaiser Permanente-San Diego Zion · San Diego, CA
- Kaiser Permanente-San Francisco · San Francisco, CA
- Kaiser Permanente-Santa Teresa-San Jose · San Jose, CA
- Kaiser Permanente San Leandro · San Leandro, CA
- Kaiser Permanente-San Marcos · San Marcos, CA
- Kaiser San Rafael-Gallinas · San Rafael, CA
- Kaiser Permanente Medical Center - Santa Clara · Santa Clara, CA
- Kaiser Permanente-Santa Rosa · Santa Rosa, CA
- Kaiser Permanente-South San Francisco · South San Francisco, CA
- Kaiser Permanente-Vallejo · Vallejo, CA
- Kaiser Permanente-Walnut Creek · Walnut Creek, CA
- Kaiser Permanente-Woodland Hills · Woodland Hills, CA
Colorado · 6
- Memorial Hospital North · Colorado Springs, CO
- UCHealth Memorial Hospital Central · Colorado Springs, CO
- Cancer Care and Hematology-Fort Collins · Fort Collins, CO
- Poudre Valley Hospital · Fort Collins, CO
- UCHealth Greeley Hospital · Greeley, CO
- Medical Center of the Rockies · Loveland, CO
Connecticut · 13
- Smilow Cancer Hospital-Derby Care Center · Derby, CT
- Smilow Cancer Hospital Care Center-Fairfield · Fairfield, CT
- Smilow Cancer Hospital Care Center at Glastonbury · Glastonbury, CT
- Smilow Cancer Hospital Care Center at Greenwich · Greenwich, CT
- Smilow Cancer Hospital Care Center - Guilford · Guilford, CT
- Smilow Cancer Hospital Care Center at Saint Francis · Hartford, CT
- Yale University · New Haven, CT
- Yale-New Haven Hospital North Haven Medical Center · North Haven, CT
- Smilow Cancer Hospital Care Center at Long Ridge · Stamford, CT
- Smilow Cancer Hospital-Torrington Care Center · Torrington, CT
- Smilow Cancer Hospital Care Center-Trumbull · Trumbull, CT
- Smilow Cancer Hospital-Waterbury Care Center · Waterbury, CT
- Smilow Cancer Hospital Care Center - Waterford · Waterford, CT
Delaware · 4
- Beebe South Coastal Health Campus · Millville, DE
- Helen F Graham Cancer Center · Newark, DE
- Medical Oncology Hematology Consultants PA · Newark, DE
- Beebe Health Campus · Rehoboth Beach, DE
District of Columbia · 1
- MedStar Georgetown University Hospital · Washington D.C., DC
Florida · 2
- Mount Sinai Medical Center · Miami Beach, FL
- AdventHealth Orlando · Orlando, FL
Georgia · 5
- Emory Saint Joseph's Hospital · Atlanta, GA
- Emory University Hospital Midtown · Atlanta, GA
- Emory University Hospital/Winship Cancer Institute · Atlanta, GA
- Emory Decatur Hospital · Decatur, GA
- Emory Johns Creek Hospital · Johns Creek, GA
Hawaii · 10
- Hawaii Cancer Care - Westridge · ‘Aiea, HI
- Pali Momi Medical Center · ‘Aiea, HI
- The Queen's Medical Center - West Oahu · ‘Ewa Beach, HI
- Hawaii Cancer Care Inc - Waterfront Plaza · Honolulu, HI
- Kaiser Permanente Moanalua Medical Center · Honolulu, HI
- Kapiolani Medical Center for Women and Children · Honolulu, HI
- Queen's Cancer Cenrer - POB I · Honolulu, HI
- Queen's Cancer Center - Kuakini · Honolulu, HI
- Queen's Medical Center · Honolulu, HI
- Straub Clinic and Hospital · Honolulu, HI
Idaho · 6
- Saint Alphonsus Cancer Care Center-Boise · Boise, ID
- Saint Alphonsus Cancer Care Center-Caldwell · Caldwell, ID
- Kootenai Health - Coeur d'Alene · Coeur d'Alene, ID
- Saint Alphonsus Cancer Care Center-Nampa · Nampa, ID
- Kootenai Clinic Cancer Services - Post Falls · Post Falls, ID
- Kootenai Clinic Cancer Services - Sandpoint · Sandpoint, ID
Illinois · 40
- Advocate Outpatient Center - Aurora · Aurora, IL
- Rush-Copley Medical Center · Aurora, IL
- Advocate Good Shepherd Hospital · Barrington, IL
- Advocate Illinois Masonic Medical Center · Chicago, IL
- Northwestern University · Chicago, IL
- Swedish Covenant Hospital · Chicago, IL
- University of Illinois · Chicago, IL
- AMG Crystal Lake - Oncology · Crystal Lake, IL
- Carle at The Riverfront · Danville, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Northwestern Medicine Cancer Center Kishwaukee · DeKalb, IL
- Advocate Good Samaritan Hospital · Downers Grove, IL
- Carle Physician Group-Effingham · Effingham, IL
- Crossroads Cancer Center · Effingham, IL
- Advocate Sherman Hospital · Elgin, IL
- NorthShore University HealthSystem-Evanston Hospital · Evanston, IL
- Northwestern Medicine Cancer Center Delnor · Geneva, IL
- NorthShore University HealthSystem-Glenbrook Hospital · Glenview, IL
- Northwestern Medicine Glenview Outpatient Center · Glenview, IL
- Northwestern Medicine Grayslake Outpatient Center · Grayslake, IL
- Advocate South Suburban Hospital · Hazel Crest, IL
- NorthShore University HealthSystem-Highland Park Hospital · Highland Park, IL
- Northwestern Medicine Lake Forest Hospital · Lake Forest, IL
- AMG Libertyville - Oncology · Libertyville, IL
- Condell Memorial Hospital · Libertyville, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- Northwestern Medicine Oak Brook · Oak Brook, IL
- Advocate Christ Medical Center · Oak Lawn, IL
- Northwestern Medicine Orland Park · Orland Park, IL
- Advocate Lutheran General Hospital · Park Ridge, IL
- Mercyhealth Cancer Institute - Rockford · Rockford, IL
- UW Health Carbone Cancer Center Rockford · Rockford, IL
- Memorial Hospital East · Shiloh, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Springfield Clinic · Springfield, IL
- Springfield Memorial Hospital · Springfield, IL
- Carle Cancer Center · Urbana, IL
- Northwestern Medicine Cancer Center Warrenville · Warrenville, IL
Indiana · 8
- Northwest Cancer Center - Crown Point · Crown Point, IN
- Northwest Oncology LLC · Dyer, IN
- Northwest Cancer Center - Hobart · Hobart, IN
- Saint Mary Medical Center · Hobart, IN
- Saint Catherine Hospital · Indianapolis, IN
- The Community Hospital · Munster, IN
- Women's Diagnostic Center - Munster · Munster, IN
- Northwest Cancer Center - Valparaiso · Valparaiso, IN
Iowa · 11
- UI Health Care Mission Cancer and Blood - Ankeny Clinic · Ankeny, IA
- Saint Anthony Regional Hospital · Carroll, IA
- Mercy Hospital · Cedar Rapids, IA
- Oncology Associates at Mercy Medical Center · Cedar Rapids, IA
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic · Clive, IA
- Broadlawns Medical Center · Des Moines, IA
- Iowa Methodist Medical Center · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Des Moines Clinic · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Laurel Clinic · Des Moines, IA
- UI Healthcare Mission Cancer and Blood - Fort Dodge · Fort Dodge, IA
- UI Health Care Mission Cancer and Blood - Waukee Clinic · Waukee, IA
Kansas · 2
- HaysMed · Hays, KS
- Lawrence Memorial Hospital · Lawrence, KS
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.