A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
NCT06172478
This study is recruiting at 12 US sites in 10 states, according to its ClinicalTrials.gov record last updated .
Summary
This is a proof-of-concept study designed to investigate HER3-DXd monotherapy in locally advanced unresectable or metastatic solid tumors. The study is enrolling cohorts of participants with melanoma [cutaneous/acral], squamous cell carcinomas of the head and neck (SCCHN), HER2-negative gastric cancer ovarian carcinoma, cervical cancer, endometrial cancer, bladder cancer, esophageal carcinoma, pancreatic carcinoma, prostate cancer, second-line gastric cancer, lung cancer, and breast cancer.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Advanced Solid Tumor
- Melanoma
- Head and Neck Cancer
- Gastric Cancer
- Ovarian Carcinoma
- Cervical Cancer
- Endometrial Cancer
- Bladder Cancer
- Esophageal Cancer
- Pancreatic Carcinoma
- Prostate Cancer
- Non-small Cell Lung Cancer (NSCLC)
- Lung Cancer
- Breast Cancer
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Daiichi Sankyo
- Last updated on ClinicalTrials.gov
- October 1, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
California · 1
- City of Hope · Duarte, CA
Connecticut · 1
- Yale Cancer Center · New Haven, CT
Florida · 1
- AdventHealth Medical Group Oncology Research at Celebration · Kissimmee, FL
Illinois · 1
- University of Illinois Cancer Center · Chicago, IL
Maryland · 1
- Johns Hopkins University · Baltimore, MD
Minnesota · 2
- Health Partners Frauenshuh Cancer Center · Saint Louis Park, MN
- Health Partners Cancer Center at Regions Hospital · Saint Paul, MN
Missouri · 1
- Washington University, School of Medicine · St Louis, MO
New York · 2
- Roswell Park Cancer Institute IDS · Buffalo, NY
- Memorial Sloan Kettering Hospital · New York, NY
Tennessee · 1
- SCRI Oncology Partners · Nashville, TN
Texas · 1
- The University of Texas MD Anderson Cancer Center · Houston, TX
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.