A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
NCT06119581
This study is recruiting at 86 US sites in 37 states, according to its ClinicalTrials.gov record last updated .
Summary
The purpose of this study is to assess if adding LY3537982 (olomorasib) in combination with standard of care anti-cancer drugs is more effective than standard of care in participants with untreated advanced NSCLC. NSCLC must have a change in a gene called KRAS G12C. Study participation, including follow-up, could last up to 3 years, depending on how you and your lung cancer are doing.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Carcinoma, Non-Small-Cell Lung
- Neoplasm Metastasis
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Eli Lilly and Company
- Last updated on ClinicalTrials.gov
- October 7, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- Clearview Cancer Institute · Huntsville, AL
Arizona · 3
- Banner MD Anderson Cancer Center · Gilbert, AZ
- Banner University Medical Center Phoenix · Phoenix, AZ
- The University of Arizona Cancer Center - North Campus · Tucson, AZ
Arkansas · 1
- Highlands Oncology Group · Springdale, AR
California · 2
- Cedars-Sinai Medical Center · Los Angeles, CA
- BASS Cancer Center · Walnut Creek, CA
Colorado · 1
- USO - Rocky Mountain Cancer Centers · Lone Tree, CO
Connecticut · 1
- Yale University School of Medicine · New Haven, CT
District of Columbia · 1
- Sibley Memorial Hospital · Washington D.C., DC
Florida · 5
- Millennium Oncology Research Clinic · Hollywood, FL
- Miami Cancer Institute at Baptist Health, Inc. · Miami, FL
- Ocala Oncology Center PL DBA Florida Cancer Affiliates - Ocala · Ocala, FL
- Orlando Health Cancer Institute · Orlando, FL
- Comprehensive Hematology Oncology · St. Petersburg, FL
Georgia · 3
- University Cancer & Blood Center, LLC · Athens, GA
- Emory University School of Medicine- Grady Campus · Atlanta, GA
- Winship Cancer Institute, Emory University · Atlanta, GA
Illinois · 3
- University of Chicago Hospital · Chicago, IL
- University of Illinois at Chicago · Chicago, IL
- Springfield Clinic Main Campus · Springfield, IL
Indiana · 4
- Parkview Research Center at Parkview Regional Medical Center · Fort Wayne, IN
- Community Cancer Center North · Indianapolis, IN
- Franciscan Health · Indianapolis, IN
- Indiana University Melvin and Bren Simon Cancer Center · Indianapolis, IN
Kansas · 1
- The University of Kansas Cancer Center - Westwood · Westwood, KS
Kentucky · 1
- University of Kentucky Chandler Medical Center · Lexington, KY
Louisiana · 1
- Mary Bird Perkins Cancer Center · Baton Rouge, LA
Maryland · 2
- Johns Hopkins Bayview Medical Center · Baltimore, MD
- USO - Maryland Oncology Hematology · Columbia, MD
Massachusetts · 2
- Boston Medical Center · Boston, MA
- Lahey Hospital & Medical Center · Burlington, MA
Michigan · 2
- University of Michigan · Ann Arbor, MI
- The Cancer & Hematology Centers · Grand Rapids, MI
Minnesota · 2
- Allina Health Cancer Institute - Abbott Northwestern Hospital · Minneapolis, MN
- HealthPartners Cancer Research Center · Saint Paul, MN
Mississippi · 1
- North Mississippi Hematology and Oncology Associates · Tupelo, MS
Missouri · 1
- Oncology Hematology Associates · Springfield, MO
Nevada · 1
- Comprehensive Cancer Centers of Nevada · Las Vegas, NV
New Hampshire · 1
- Dartmouth-Hitchcock Medical Center · Lebanon, NH
New Jersey · 1
- The Valley Hospital, Inc. · Paramus, NJ
New Mexico · 1
- University of New Mexico Comprehensive Cancer Center · Albuquerque, NM
New York · 6
- Maimonides Cancer Center · Brooklyn, NY
- Northwell Health/ RJ Zuckerberg Cancer Center · Lake Success, NY
- Perlmutter Cancer Center at NYU Langone Hospital - Long Island · Mineola, NY
- Laura and Isaac Perlmutter Cancer Center · New York, NY
- Manhattan Eye, Ear and Throat Hospital · New York, NY
- Memorial Sloan Kettering Cancer Center · New York, NY
North Carolina · 2
- University of North Carolina Medical Center · Chapel Hill, NC
- Duke Cancer Institute · Durham, NC
Ohio · 3
- Miami Valley Hospital South · Centerville, OH
- USO - Oncology Hematology Care · Cincinnati, OH
- The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer -T · Columbus, OH
Oregon · 5
- USO - Oncology Associates of Oregon · Eugene, OR
- Asante Rogue Regional Medical Center · Medford, OR
- Kaiser Permanente Interstate Medical Office Central · Portland, OR
- Providence Portland Medical Center · Portland, OR
- Providence St. Vincent Medical Center · Portland, OR
Pennsylvania · 3
- USO - Alliance Cancer Specialists, PC · Horsham, PA
- Thomas Jefferson University, Sidney Kimmel Cancer Center - Clinical Trials Office · Philadelphia, PA
- UPMC Hillman Cancer Center · Pittsburgh, PA
Rhode Island · 1
- Lifespan Cancer Institute · Providence, RI
South Carolina · 3
- Medical University of South Carolina · Charleston, SC
- Prisma Health Cancer Institute · Greenville, SC
- Lexington Medical Center · West Columbia, SC
Tennessee · 5
- Tennessee Oncology Chattanooga · Chattanooga, TN
- University of Tennessee Medical Center · Knoxville, TN
- Baptist Memorial Hospital-Memphis · Memphis, TN
- Tennessee Oncology · Nashville, TN
- USO - US Oncology Research Network · Nashville, TN
Texas · 6
- USO - Texas Oncology · Austin, TX
- William Beaumont Army Medical Center · Fort Bliss, TX
- Houston Methodist Hospital · Houston, TX
- Lumi Research · Houston, TX
- University of Texas MD Anderson Cancer Center · Houston, TX
- USO - Texas Oncology · Webster, TX
Vermont · 1
- The University of Vermont Medical Center Inc. · Burlington, VT
Virginia · 3
- University of Virginia Health System · Charlottesville, VA
- USO - Virginia Cancer Specialists · Fairfax, VA
- VCU Health Adult Outpatient Pavillion · Richmond, VA
Washington · 5
- Swedish Cancer Institute - Edmonds · Edmonds, WA
- Kadlec Clinic Hematology and Oncology · Kennewick, WA
- Swedish Medical Center · Seattle, WA
- VA Puget Sound Health Care System · Seattle, WA
- USO - Northwest Cancer Specialists · Vancouver, WA
Wisconsin · 1
- SSM Health Dean Medical Group - South Madison Campus Health Research/Circuit Clinical · Madison, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.