Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial
NCT06096844
This study is recruiting at 264 US sites in 33 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase III trial compares the effect of adding chemotherapy to immunotherapy (pembrolizumab) versus immunotherapy alone in treating patients with stage IIIB-IV lung cancer. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Advanced Lung Non-Small Cell Carcinoma
- Stage IIIB Lung Cancer AJCC v8
- Stage IIIC Lung Cancer AJCC v8
- Stage IV Lung Cancer AJCC v8
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 70 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- National Cancer Institute (NCI)
- Last updated on ClinicalTrials.gov
- October 8, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arkansas · 4
- Highlands Oncology Group - Fayetteville · Fayetteville, AR
- Mercy Hospital Fort Smith · Fort Smith, AR
- Highlands Oncology Group - Rogers · Rogers, AR
- Highlands Oncology Group · Springdale, AR
Connecticut · 2
- Stamford Hospital/Bennett Cancer Center · Stamford, CT
- Veterans Affairs Connecticut Healthcare System-West Haven Campus · West Haven, CT
District of Columbia · 1
- George Washington University Medical Center · Washington D.C., DC
Florida · 16
- UM Sylvester Comprehensive Cancer Center at Aventura · Aventura, FL
- UM Sylvester Comprehensive Cancer Center at Coral Gables · Coral Gables, FL
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach · Deerfield Beach, FL
- Holy Cross Hospital · Fort Lauderdale, FL
- Malcom Randall Veterans Administration Medical Center · Gainesville, FL
- UF Health Cancer Institute - Gainesville · Gainesville, FL
- The Watson Clinic · Lakeland, FL
- UM Sylvester Comprehensive Cancer Center at Kendall · Miami, FL
- University of Miami Miller School of Medicine-Sylvester Cancer Center · Miami, FL
- Sacred Heart Hospital · Pensacola, FL
- UM Sylvester Comprehensive Cancer Center at Plantation · Plantation, FL
- James A. Haley Veterans Affairs Hospital · Tampa, FL
- Moffitt Cancer Center · Tampa, FL
- Moffitt Cancer Center - McKinley Campus · Tampa, FL
- Moffitt Cancer Center-International Plaza · Tampa, FL
- Moffitt Cancer Center at Wesley Chapel · Wesley Chapel, FL
Georgia · 1
- CTCA at Southeastern Regional Medical Center · Newnan, GA
Idaho · 6
- Saint Alphonsus Cancer Care Center-Boise · Boise, ID
- Saint Alphonsus Cancer Care Center-Caldwell · Caldwell, ID
- Kootenai Health - Coeur d'Alene · Coeur d'Alene, ID
- Saint Alphonsus Cancer Care Center-Nampa · Nampa, ID
- Kootenai Clinic Cancer Services - Post Falls · Post Falls, ID
- Kootenai Clinic Cancer Services - Sandpoint · Sandpoint, ID
Illinois · 29
- Advocate Outpatient Center - Aurora · Aurora, IL
- Rush-Copley Medical Center · Aurora, IL
- Advocate Good Shepherd Hospital · Barrington, IL
- SIH Cancer Institute · Carterville, IL
- Advocate Illinois Masonic Medical Center · Chicago, IL
- Rush MD Anderson Cancer Center · Chicago, IL
- University of Illinois · Chicago, IL
- AMG Crystal Lake - Oncology · Crystal Lake, IL
- Carle at The Riverfront · Danville, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Advocate Good Samaritan Hospital · Downers Grove, IL
- Carle Physician Group-Effingham · Effingham, IL
- Crossroads Cancer Center · Effingham, IL
- Advocate Sherman Hospital · Elgin, IL
- Advocate South Suburban Hospital · Hazel Crest, IL
- AMG Libertyville - Oncology · Libertyville, IL
- Condell Memorial Hospital · Libertyville, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- Loyola University Medical Center · Maywood, IL
- SSM Health Good Samaritan · Mount Vernon, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- Advocate Christ Medical Center · Oak Lawn, IL
- Advocate Lutheran General Hospital · Park Ridge, IL
- UW Health Carbone Cancer Center Rockford · Rockford, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Springfield Clinic · Springfield, IL
- Springfield Memorial Hospital · Springfield, IL
- Carle Cancer Center · Urbana, IL
Indiana · 8
- Northwest Cancer Center - Crown Point · Crown Point, IN
- Northwest Oncology LLC · Dyer, IN
- Northwest Cancer Center - Hobart · Hobart, IN
- Saint Mary Medical Center · Hobart, IN
- Saint Catherine Hospital · Indianapolis, IN
- The Community Hospital · Munster, IN
- Women's Diagnostic Center - Munster · Munster, IN
- Northwest Cancer Center - Valparaiso · Valparaiso, IN
Iowa · 10
- UI Health Care Mission Cancer and Blood - Ankeny Clinic · Ankeny, IA
- Mercy Hospital · Cedar Rapids, IA
- Oncology Associates at Mercy Medical Center · Cedar Rapids, IA
- Mercy Cancer Center-West Lakes · Clive, IA
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic · Clive, IA
- Iowa Methodist Medical Center · Des Moines, IA
- Mercy Medical Center - Des Moines · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Des Moines Clinic · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Laurel Clinic · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Waukee Clinic · Waukee, IA
Kentucky · 3
- University of Kentucky/Markey Cancer Center · Lexington, KY
- The James Graham Brown Cancer Center at University of Louisville · Louisville, KY
- UofL Health Medical Center Northeast · Louisville, KY
Maine · 1
- Lafayette Family Cancer Center-EMMC · Brewer, ME
Maryland · 3
- Sinai Hospital of Baltimore · Baltimore, MD
- University of Maryland/Greenebaum Cancer Center · Baltimore, MD
- William E Kahlert Regional Cancer Center/Sinai Hospital · Westminster, MD
Massachusetts · 6
- Tufts Medical Center · Boston, MA
- Dana-Farber Cancer Institute at Boston Medical Center - Brighton · Brighton, MA
- Dana-Farber Cancer Institute at Foxborough · Foxborough, MA
- Dana Farber-Merrimack Valley · Methuen, MA
- Dana-Farber/Brigham and Women's Cancer Center at Milford Regional · Milford, MA
- Dana-Farber/Brigham and Women's Cancer Center at South Shore · South Weymouth, MA
Michigan · 23
- Bronson Battle Creek · Battle Creek, MI
- Trinity Health IHA Medical Group Hematology Oncology - Brighton · Brighton, MI
- Trinity Health IHA Medical Group Hematology Oncology - Canton · Canton, MI
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital · Chelsea, MI
- Cancer Hematology Centers - Flint · Flint, MI
- Genesys Hurley Cancer Institute · Flint, MI
- Hurley Medical Center · Flint, MI
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital · Grand Rapids, MI
- Bronson Methodist Hospital · Kalamazoo, MI
- West Michigan Cancer Center · Kalamazoo, MI
- University of Michigan Health - Sparrow Lansing · Lansing, MI
- Trinity Health Saint Mary Mercy Livonia Hospital · Livonia, MI
- Corewell Health Lakeland Hospitals - Niles Hospital · Niles, MI
- Michigan Healthcare Professionals Pontiac · Pontiac, MI
- Trinity Health Saint Joseph Mercy Oakland Hospital · Pontiac, MI
- Corewell Health Reed City Hospital · Reed City, MI
- MyMichigan Medical Center Saginaw · Saginaw, MI
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center · Saint Joseph, MI
- Corewell Health Lakeland Hospitals - Saint Joseph Hospital · Saint Joseph, MI
- MyMichigan Medical Center Tawas · Tawas City, MI
- Munson Medical Center · Traverse City, MI
- University of Michigan Health - West · Wyoming, MI
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus · Ypsilanti, MI
Minnesota · 18
- Sanford Joe Lueken Cancer Center · Bemidji, MN
- Minnesota Oncology - Burnsville · Burnsville, MN
- Mercy Hospital · Coon Rapids, MN
- Essentia Health - Deer River Clinic · Deer River, MN
- Essentia Health Cancer Center · Duluth, MN
- Fairview Southdale Hospital · Edina, MN
- Essentia Health Hibbing Clinic · Hibbing, MN
- Mayo Clinic Health Systems-Mankato · Mankato, MN
- Saint John's Hospital - Healtheast · Maplewood, MN
- Abbott-Northwestern Hospital · Minneapolis, MN
- New Ulm Medical Center · New Ulm, MN
- North Memorial Medical Health Center · Robbinsdale, MN
- Park Nicollet Clinic - Saint Louis Park · Saint Louis Park, MN
- Regions Hospital · Saint Paul, MN
- United Hospital · Saint Paul, MN
- Essentia Health Sandstone · Sandstone, MN
- Saint Francis Regional Medical Center · Shakopee, MN
- Essentia Health Virginia Clinic · Virginia, MN
Missouri · 5
- Saint Francis Medical Center · Cape Girardeau, MO
- Kansas City Veterans Affairs Medical Center · Kansas City, MO
- Lake Regional Hospital · Osage Beach, MO
- Mercy Hospital Saint Louis · St Louis, MO
- Mercy Hospital South · St Louis, MO
Montana · 6
- Community Hospital of Anaconda · Anaconda, MT
- Billings Clinic Cancer Center · Billings, MT
- Bozeman Health Deaconess Hospital · Bozeman, MT
- Benefis Sletten Cancer Institute · Great Falls, MT
- Logan Health Medical Center · Kalispell, MT
- Community Medical Center · Missoula, MT
New Hampshire · 2
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center · Lebanon, NH
- The Dana-Farber Cancer Institute at Londonderry · Londonderry, NH
New York · 6
- Glens Falls Hospital · Glens Falls, NY
- Upstate Cancer Center at Oswego · Oswego, NY
- University of Rochester · Rochester, NY
- Stony Brook University Medical Center · Stony Brook, NY
- State University of New York Upstate Medical University · Syracuse, NY
- SUNY Upstate Medical Center-Community Campus · Syracuse, NY
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.