A Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it is Against Rituximab Combined With Chemotherapy, in Adult Patients With Previously Untreated Diffuse Large B-cell Lymphoma
NCT06091865
This study is recruiting at 20 US sites in 14 states, according to its ClinicalTrials.gov record last updated .
Summary
This study is researching an experimental drug called odronextamab, referred to as study drug, when used in combination with chemotherapy. The study is focused on patients with Diffuse Large B-cell Lymphoma (DLBCL) that have not been treated before (called "previously untreated"). Patients with DLBCL that have come back after treatment (called "relapsed"), or have not responded to treatment (called "refractory"), can also participate in this study.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Diffuse Large B-cell Lymphoma (DLBCL)
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Regeneron Pharmaceuticals
- Last updated on ClinicalTrials.gov
- October 7, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 1
- Mayo Clinic - Arizona · Scottsdale, AZ
California · 3
- David Geffen School of Medicine at UCLA · Los Angeles, CA
- University of California Irvine Medical Center · Orange, CA
- UC Davis Comprehensive Cancer Center · Sacramento, CA
Florida · 1
- Mayo Clinic Jacksonville · Jacksonville, FL
Indiana · 3
- Indiana University Melvin and Bren Simon Comprehensive Cancer Center · Indianapolis, IN
- St Vincent Ascension at Peyton Manning Childrens Hospital · Indianapolis, IN
- Investigative Clinical Research of Indiana · Noblesville, IN
Kentucky · 1
- University of Kentucky · Lexington, KY
Maryland · 1
- University of Maryland Greenebaum Comprehensive Cancer Center · Baltimore, MD
Massachusetts · 1
- Beth Israel Deaconess Medical Center · Boston, MA
Michigan · 2
- Henry Ford Health System · Detroit, MI
- Cancer and Hematology Centers of Western Michigan · Grand Rapids, MI
Minnesota · 1
- Mayo Clinic - Rochester · Rochester, MN
New Jersey · 1
- Rutgers Cancer Institute of New Jersey · New Brunswick, NJ
New York · 1
- Stony Brook University Hospital · Stony Brook, NY
North Carolina · 2
- Duke University Medical Center · Durham, NC
- East Carolina University · Greenville, NC
Ohio · 1
- University Hospitals Cleveland Medical Center · Cleveland, OH
Utah · 1
- Community Cancer Trials of Utah · Ogden, UT
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.