LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia
NCT06073431
This study is recruiting at 195 US sites in 20 states, according to its ClinicalTrials.gov record last updated .
Summary
This study evaluates cancer-related weight and muscle mass loss, symptoms, and physical function (cachexia) in patients undergoing treatment for colorectal, lung, or pancreatic cancer that cannot be removed by surgery (unresectable) or is stage IV. Patients with these cancer types are at risk for developing cancer cachexia (CC), which is defined as weight loss, muscle loss, and fat loss due to cancer. CC has been associated with reduced physical performance, impaired quality of life, and poorer survival.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Advanced Colorectal Carcinoma
- Advanced Lung Non-Small Cell Carcinoma
- Advanced Pancreatic Adenocarcinoma
- Stage IV Colorectal Cancer AJCC v8
- Stage IV Lung Cancer AJCC v8
- Stage IV Pancreatic Cancer AJCC v8
- Unresectable Colorectal Carcinoma
- Unresectable Lung Non-Small Cell Carcinoma
- Unresectable Pancreatic Adenocarcinoma
Eligibility basics and study details
- Study type
- Observational
- Phase
- Not applicable
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- University of Rochester
- Last updated on ClinicalTrials.gov
- January 9, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arkansas · 1
- Mercy Hospital Fort Smith · Fort Smith, AR
Delaware · 6
- Beebe South Coastal Health Campus · Millville, DE
- Christiana Care Health System-Christiana Hospital · Newark, DE
- Helen F Graham Cancer Center · Newark, DE
- Medical Oncology Hematology Consultants PA · Newark, DE
- Beebe Health Campus · Rehoboth Beach, DE
- Christiana Care Health System-Wilmington Hospital · Wilmington, DE
District of Columbia · 1
- MedStar Georgetown University Hospital · Washington D.C., DC
Georgia · 11
- Northside Hospital · Atlanta, GA
- Northeast Georgia Medical Center Braselton · Braselton, GA
- John B Amos Cancer Center · Columbus, GA
- Northside Hospital - Duluth · Duluth, GA
- Northeast Georgia Medical Center-Gainesville · Gainesville, GA
- The Longstreet Clinic - Gainesville · Gainesville, GA
- Northside Hospital - Gwinnett · Lawrenceville, GA
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler · Savannah, GA
- Memorial Health University Medical Center · Savannah, GA
- Tift Regional Medical Center · Tifton, GA
- South Georgia Medical Center/Pearlman Cancer Center · Valdosta, GA
Hawaii · 10
- Hawaii Cancer Care - Westridge · ‘Aiea, HI
- Pali Momi Medical Center · ‘Aiea, HI
- Queen's Cancer Center - Pearlridge · ‘Aiea, HI
- The Queen's Medical Center - West Oahu · ‘Ewa Beach, HI
- Hawaii Cancer Care Inc - Waterfront Plaza · Honolulu, HI
- Kapiolani Medical Center for Women and Children · Honolulu, HI
- Queen's Cancer Cenrer - POB I · Honolulu, HI
- Queen's Cancer Center - Kuakini · Honolulu, HI
- Queen's Medical Center · Honolulu, HI
- Straub Clinic and Hospital · Honolulu, HI
Illinois · 43
- OSF Saint Anthony's Health Center · Alton, IL
- Advocate Good Shepherd Hospital · Barrington, IL
- Illinois CancerCare-Bloomington · Bloomington, IL
- Illinois CancerCare-Canton · Canton, IL
- Memorial Hospital of Carbondale · Carbondale, IL
- SIH Cancer Institute · Carterville, IL
- Illinois CancerCare-Carthage · Carthage, IL
- Centralia Oncology Clinic · Centralia, IL
- Advocate Illinois Masonic Medical Center · Chicago, IL
- AMG Crystal Lake - Oncology · Crystal Lake, IL
- Carle at The Riverfront · Danville, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Illinois CancerCare-Dixon · Dixon, IL
- Advocate Good Samaritan Hospital · Downers Grove, IL
- Crossroads Cancer Center · Effingham, IL
- Advocate Sherman Hospital · Elgin, IL
- Illinois CancerCare-Eureka · Eureka, IL
- Illinois CancerCare-Galesburg · Galesburg, IL
- Advocate South Suburban Hospital · Hazel Crest, IL
- Illinois CancerCare-Kewanee Clinic · Kewanee, IL
- AMG Libertyville - Oncology · Libertyville, IL
- Condell Memorial Hospital · Libertyville, IL
- Illinois CancerCare-Macomb · Macomb, IL
- Carle BroMenn Medical Center · Normal, IL
- Carle Cancer Institute Normal · Normal, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- HSHS Saint Elizabeth's Hospital · O'Fallon, IL
- Advocate Christ Medical Center · Oak Lawn, IL
- Advocate Outpatient Center - Oak Lawn · Oak Lawn, IL
- Illinois CancerCare-Ottawa Clinic · Ottawa, IL
- Advocate Lutheran General Hospital · Park Ridge, IL
- Illinois CancerCare-Pekin · Pekin, IL
- Illinois CancerCare-Peoria · Peoria, IL
- Methodist Medical Center of Illinois · Peoria, IL
- Illinois CancerCare-Peru · Peru, IL
- Valley Radiation Oncology · Peru, IL
- Illinois CancerCare-Princeton · Princeton, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Springfield Clinic · Springfield, IL
- Springfield Memorial Hospital · Springfield, IL
- Carle Cancer Center · Urbana, IL
- Illinois CancerCare - Washington · Washington, IL
Louisiana · 1
- Ochsner Medical Center Jefferson · New Orleans, LA
Maryland · 1
- Christiana Care - Union Hospital · Elkton, MD
Michigan · 5
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital · Grand Rapids, MI
- Trinity Health Grand Rapids Hospital · Grand Rapids, MI
- Dickinson County Healthcare System · Iron Mountain, MI
- Bronson Methodist Hospital · Kalamazoo, MI
- West Michigan Cancer Center · Kalamazoo, MI
Minnesota · 21
- Minnesota Oncology - Burnsville · Burnsville, MN
- Mercy Hospital · Coon Rapids, MN
- Fairview Southdale Hospital · Edina, MN
- Fairview Clinics and Surgery Center Maple Grove · Maple Grove, MN
- Minnesota Oncology Hematology PA-Maplewood · Maplewood, MN
- Saint John's Hospital - Healtheast · Maplewood, MN
- Abbott-Northwestern Hospital · Minneapolis, MN
- Hennepin County Medical Center · Minneapolis, MN
- Monticello Cancer Center · Monticello, MN
- New Ulm Medical Center · New Ulm, MN
- Fairview Northland Medical Center · Princeton, MN
- North Memorial Medical Health Center · Robbinsdale, MN
- Park Nicollet Clinic - Saint Louis Park · Saint Louis Park, MN
- Regions Hospital · Saint Paul, MN
- United Hospital · Saint Paul, MN
- Saint Francis Regional Medical Center · Shakopee, MN
- Lakeview Hospital · Stillwater, MN
- Ridgeview Medical Center · Waconia, MN
- Rice Memorial Hospital · Willmar, MN
- Minnesota Oncology Hematology PA-Woodbury · Woodbury, MN
- Fairview Lakes Medical Center · Wyoming, MN
Missouri · 8
- Parkland Health Center - Farmington · Farmington, MO
- Lake Regional Hospital · Osage Beach, MO
- Sainte Genevieve County Memorial Hospital · Sainte Genevieve, MO
- Mercy Hospital Springfield · Springfield, MO
- Mercy Hospital South · St Louis, MO
- Missouri Baptist Medical Center · St Louis, MO
- Missouri Baptist Sullivan Hospital · Sullivan, MO
- BJC Outpatient Center at Sunset Hills · Sunset Hills, MO
Nevada · 16
- Carson Tahoe Regional Medical Center · Carson City, NV
- Comprehensive Cancer Centers of Nevada - Henderson · Henderson, NV
- Comprehensive Cancer Centers of Nevada-Southeast Henderson · Henderson, NV
- OptumCare Cancer Care at Seven Hills · Henderson, NV
- Urology Specialists of Nevada - Green Valley · Henderson, NV
- Comprehensive Cancer Centers of Nevada - Central Valley · Las Vegas, NV
- Comprehensive Cancer Centers of Nevada - Northwest · Las Vegas, NV
- Comprehensive Cancer Centers of Nevada - Town Center · Las Vegas, NV
- Comprehensive Cancer Centers of Nevada-Summerlin · Las Vegas, NV
- OptumCare Cancer Care at Charleston · Las Vegas, NV
- OptumCare Cancer Care at Fort Apache · Las Vegas, NV
- OptumCare Cancer Care at MountainView · Las Vegas, NV
- Summerlin Hospital Medical Center · Las Vegas, NV
- Urology Specialists of Nevada - Northwest · Las Vegas, NV
- Urology Specialists of Nevada - Southwest · Las Vegas, NV
- Renown Regional Medical Center · Reno, NV
New York · 9
- Noyes Memorial Hospital/Myers Cancer Center · Dansville, NY
- Northwell Health/Center for Advanced Medicine · Lake Success, NY
- Lenox Hill Hospital · New York, NY
- Manhattan Eye Ear and Throat Hospital · New York, NY
- Highland Hospital · Rochester, NY
- Pluta Cancer Center · Rochester, NY
- University of Rochester · Rochester, NY
- Wilmot Cancer Institute Radiation Oncology at Greece · Rochester, NY
- Wilmot Cancer Institute at Webster · Webster, NY
Ohio · 2
- Strecker Cancer Center-Belpre · Belpre, OH
- Marietta Memorial Hospital · Marietta, OH
Oregon · 4
- Providence Newberg Medical Center · Newberg, OR
- Providence Willamette Falls Medical Center · Oregon City, OR
- Providence Portland Medical Center · Portland, OR
- Providence Saint Vincent Medical Center · Portland, OR
Pennsylvania · 3
- Geisinger Medical Center · Danville, PA
- Geisinger Medical Oncology-Lewisburg · Lewisburg, PA
- Geisinger Wyoming Valley/Henry Cancer Center · Wilkes-Barre, PA
South Carolina · 8
- AnMed Health Cancer Center · Anderson, SC
- Saint Joseph's/Candler - Bluffton Campus · Bluffton, SC
- Gibbs Cancer Center-Gaffney · Gaffney, SC
- Prisma Health Cancer Institute - Butternut · Greenville, SC
- Prisma Health Cancer Institute - Eastside · Greenville, SC
- Prisma Health Cancer Institute - Faris · Greenville, SC
- Gibbs Cancer Center-Pelham · Greer, SC
- South Carolina Cancer Specialists PC · Hilton Head Island, SC
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.