Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)
NCT06031688
This study is recruiting at 246 US sites in 41 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase II Expanded Lung-MAP treatment trial tests tepotinib with or without ramucirumab for the treatment of patients with advanced non-small cell lung cancer that has spread from where it first started (primary site) to other places in the body (stage IV) or that has come back after a period of improvement (recurrent). Tepotinib is used in patients whose cancer has a mutated (changed) form of a gene called MET. It is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal MET protein that signals tumor cells to multiply.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Recurrent Lung Non-Small Cell Carcinoma
- Stage IV Lung Cancer AJCC v8
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2
- Ages
- 18 Minutes and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- SWOG Cancer Research Network
- Last updated on ClinicalTrials.gov
- October 9, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 4
- Gulf Health Hospitals Inc/Infirmary Cancer Care - Malbis · Daphne, AL
- Thomas Hospital · Fairhope, AL
- Mobile Infirmary Medical Center · Mobile, AL
- Gulf Health Hospitals Inc/Infirmary Cancer Care - Saraland · Saraland, AL
Arkansas · 2
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro · Jonesboro, AR
- University of Arkansas for Medical Sciences · Little Rock, AR
California · 22
- Sutter Auburn Faith Hospital · Auburn, CA
- Alta Bates Summit Medical Center-Herrick Campus · Berkeley, CA
- Tower Cancer Research Foundation · Beverly Hills, CA
- Palo Alto Medical Foundation-Fremont · Fremont, CA
- UC San Diego Moores Cancer Center · La Jolla, CA
- Cedars-Sinai Medical Center · Los Angeles, CA
- Memorial Medical Center · Modesto, CA
- Palo Alto Medical Foundation Health Care · Palo Alto, CA
- Eisenhower Medical Center · Rancho Mirage, CA
- Sutter Roseville Medical Center · Roseville, CA
- Sutter Medical Center Sacramento · Sacramento, CA
- University of California Davis Comprehensive Cancer Center · Sacramento, CA
- California Pacific Medical Center-Pacific Campus · San Francisco, CA
- Kaiser Permanente-San Francisco · San Francisco, CA
- Mills Health Center · San Mateo, CA
- Palo Alto Medical Foundation-Santa Cruz · Santa Cruz, CA
- Sutter Pacific Medical Foundation · Santa Rosa, CA
- Palo Alto Medical Foundation-Sunnyvale · Sunnyvale, CA
- Cedars-Sinai Cancer - Tarzana · Tarzana, CA
- Torrance Memorial Physician Network - Cancer Care · Torrance, CA
- Kaiser Permanente-Vallejo · Vallejo, CA
- Sutter Solano Medical Center/Cancer Center · Vallejo, CA
Colorado · 7
- UCHealth University of Colorado Hospital · Aurora, CO
- Memorial Hospital North · Colorado Springs, CO
- UCHealth Memorial Hospital Central · Colorado Springs, CO
- Cancer Care and Hematology-Fort Collins · Fort Collins, CO
- Poudre Valley Hospital · Fort Collins, CO
- UCHealth Greeley Hospital · Greeley, CO
- Medical Center of the Rockies · Loveland, CO
Connecticut · 13
- Smilow Cancer Hospital-Derby Care Center · Derby, CT
- Smilow Cancer Hospital Care Center-Fairfield · Fairfield, CT
- Smilow Cancer Hospital Care Center at Glastonbury · Glastonbury, CT
- Smilow Cancer Hospital Care Center at Greenwich · Greenwich, CT
- Smilow Cancer Hospital Care Center - Guilford · Guilford, CT
- Smilow Cancer Hospital Care Center at Saint Francis · Hartford, CT
- Yale University · New Haven, CT
- Yale-New Haven Hospital North Haven Medical Center · North Haven, CT
- Smilow Cancer Hospital Care Center at Long Ridge · Stamford, CT
- Smilow Cancer Hospital-Torrington Care Center · Torrington, CT
- Smilow Cancer Hospital Care Center-Trumbull · Trumbull, CT
- Smilow Cancer Hospital-Waterbury Care Center · Waterbury, CT
- Smilow Cancer Hospital Care Center - Waterford · Waterford, CT
Delaware · 2
- Bayhealth Hospital Kent Campus · Dover, DE
- Bayhealth Hospital Sussex Campus · Milford, DE
District of Columbia · 1
- Kaiser Permanente-Capitol Hill Medical Center · Washington D.C., DC
Florida · 2
- Mayo Clinic in Florida · Jacksonville, FL
- Moffitt Cancer Center · Tampa, FL
Georgia · 2
- University Cancer and Blood Center LLC · Athens, GA
- Northeast Georgia Medical Center-Gainesville · Gainesville, GA
Idaho · 6
- Saint Alphonsus Cancer Care Center-Boise · Boise, ID
- Saint Alphonsus Cancer Care Center-Caldwell · Caldwell, ID
- Kootenai Health - Coeur d'Alene · Coeur d'Alene, ID
- Saint Alphonsus Cancer Care Center-Nampa · Nampa, ID
- Kootenai Clinic Cancer Services - Post Falls · Post Falls, ID
- Kootenai Clinic Cancer Services - Sandpoint · Sandpoint, ID
Illinois · 38
- Illinois CancerCare-Bloomington · Bloomington, IL
- Illinois CancerCare-Canton · Canton, IL
- Illinois CancerCare-Carthage · Carthage, IL
- John H Stroger Jr Hospital of Cook County · Chicago, IL
- Northwestern University · Chicago, IL
- Carle at The Riverfront · Danville, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Northwestern Medicine Cancer Center Kishwaukee · DeKalb, IL
- Illinois CancerCare-Dixon · Dixon, IL
- Carle Physician Group-Effingham · Effingham, IL
- Crossroads Cancer Center · Effingham, IL
- Illinois CancerCare-Eureka · Eureka, IL
- Illinois CancerCare-Galesburg · Galesburg, IL
- Northwestern Medicine Cancer Center Delnor · Geneva, IL
- Northwestern Medicine Glenview Outpatient Center · Glenview, IL
- Northwestern Medicine Grayslake Outpatient Center · Grayslake, IL
- Edward Hines Jr VA Hospital · Hines, IL
- Illinois CancerCare-Kewanee Clinic · Kewanee, IL
- Northwestern Medicine Lake Forest Hospital · Lake Forest, IL
- Illinois CancerCare-Macomb · Macomb, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- Loyola University Medical Center · Maywood, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- Northwestern Medicine Oak Brook · Oak Brook, IL
- Northwestern Medicine Orland Park · Orland Park, IL
- Illinois CancerCare-Ottawa Clinic · Ottawa, IL
- Illinois CancerCare-Pekin · Pekin, IL
- Illinois CancerCare-Peoria · Peoria, IL
- Illinois CancerCare-Peru · Peru, IL
- Illinois CancerCare-Princeton · Princeton, IL
- Memorial Hospital East · Shiloh, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Springfield Clinic · Springfield, IL
- Springfield Memorial Hospital · Springfield, IL
- Carle Cancer Center · Urbana, IL
- Northwestern Medicine Cancer Center Warrenville · Warrenville, IL
- Illinois CancerCare - Washington · Washington, IL
Indiana · 8
- Northwest Cancer Center - Crown Point · Crown Point, IN
- Northwest Oncology LLC · Dyer, IN
- Saint Mary Medical Center · Hobart, IN
- Indiana University/Melvin and Bren Simon Cancer Center · Indianapolis, IN
- Saint Catherine Hospital · Indianapolis, IN
- The Community Hospital · Munster, IN
- Women's Diagnostic Center - Munster · Munster, IN
- Northwest Cancer Center - Valparaiso · Valparaiso, IN
Iowa · 11
- Mary Greeley Medical Center · Ames, IA
- McFarland Clinic - Ames · Ames, IA
- UI Health Care Mission Cancer and Blood - Ankeny Clinic · Ankeny, IA
- Physicians' Clinic of Iowa PC · Cedar Rapids, IA
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic · Clive, IA
- Iowa Methodist Medical Center · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Des Moines Clinic · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Laurel Clinic · Des Moines, IA
- McFarland Clinic - Trinity Cancer Center · Fort Dodge, IA
- McFarland Clinic - Marshalltown · Marshalltown, IA
- UI Health Care Mission Cancer and Blood - Waukee Clinic · Waukee, IA
Kansas · 10
- University of Kansas Clinical Research Center · Fairway, KS
- HaysMed · Hays, KS
- University of Kansas Cancer Center · Kansas City, KS
- Lawrence Memorial Hospital · Lawrence, KS
- The University of Kansas Cancer Center - Olathe · Olathe, KS
- University of Kansas Cancer Center-Overland Park · Overland Park, KS
- University of Kansas Hospital-Indian Creek Campus · Overland Park, KS
- Salina Regional Health Center · Salina, KS
- University of Kansas Health System Saint Francis Campus · Topeka, KS
- University of Kansas Hospital-Westwood Cancer Center · Westwood, KS
Kentucky · 1
- University of Kentucky/Markey Cancer Center · Lexington, KY
Maine · 1
- Lafayette Family Cancer Center-EMMC · Brewer, ME
Maryland · 4
- Kaiser Permanente-Woodlawn Medical Center · Baltimore, MD
- Kaiser Permanente-Gaithersburg Medical Center · Gaithersburg, MD
- Kaiser Permanente - Largo Medical Center · Largo, MD
- Kaiser Permanente Lutherville - Timonium Medical Center · Lutherville, MD
Massachusetts · 2
- Lahey Clinic · Burlington, MA
- UMass Memorial Medical Center - University Campus · Worcester, MA
Michigan · 14
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor · Ann Arbor, MI
- Trinity Health IHA Medical Group Hematology Oncology - Brighton · Brighton, MI
- Trinity Health Medical Center - Brighton · Brighton, MI
- Trinity Health IHA Medical Group Hematology Oncology - Canton · Canton, MI
- Trinity Health Medical Center - Canton · Canton, MI
- Chelsea Hospital · Chelsea, MI
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital · Chelsea, MI
- Cancer Hematology Centers - Flint · Flint, MI
- Genesys Hurley Cancer Institute · Flint, MI
- Hurley Medical Center · Flint, MI
- University of Michigan Health - Sparrow Lansing · Lansing, MI
- Trinity Health Saint Mary Mercy Livonia Hospital · Livonia, MI
- Trinity Health Saint Joseph Mercy Oakland Hospital · Pontiac, MI
- MyMichigan Medical Center Saginaw · Saginaw, MI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.