Testing Continuous Versus Intermittent Treatment With the Study Drug Zanubrutinib for Older Patients With Previously Untreated Mantle Cell Lymphoma
NCT05976763
This study is recruiting at 220 US sites in 30 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase III trial tests whether continuous or intermittent zanubrutinib after achieving a complete remission (CR) with rituximab works in older adult patients with mantle cell lymphoma (MCL) who have not received treatment in the past (previously untreated). Rituximab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. Zanubrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Mantle Cell Lymphoma
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 60 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Alliance for Clinical Trials in Oncology
- Last updated on ClinicalTrials.gov
- October 2, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arkansas · 1
- University of Arkansas for Medical Sciences · Little Rock, AR
California · 2
- Tower Cancer Research Foundation · Beverly Hills, CA
- Cedars-Sinai Medical Center · Los Angeles, CA
Connecticut · 13
- Smilow Cancer Hospital-Derby Care Center · Derby, CT
- Smilow Cancer Hospital Care Center-Fairfield · Fairfield, CT
- Smilow Cancer Hospital Care Center at Glastonbury · Glastonbury, CT
- Smilow Cancer Hospital Care Center at Greenwich · Greenwich, CT
- Smilow Cancer Hospital Care Center - Guilford · Guilford, CT
- Smilow Cancer Hospital Care Center at Saint Francis · Hartford, CT
- Yale University · New Haven, CT
- Yale-New Haven Hospital North Haven Medical Center · North Haven, CT
- Smilow Cancer Hospital Care Center at Long Ridge · Stamford, CT
- Smilow Cancer Hospital-Torrington Care Center · Torrington, CT
- Smilow Cancer Hospital Care Center-Trumbull · Trumbull, CT
- Smilow Cancer Hospital-Waterbury Care Center · Waterbury, CT
- Smilow Cancer Hospital Care Center - Waterford · Waterford, CT
Delaware · 2
- Helen F Graham Cancer Center · Newark, DE
- Medical Oncology Hematology Consultants PA · Newark, DE
Georgia · 7
- Phoebe Putney Memorial Hospital · Albany, GA
- Emory Saint Joseph's Hospital · Atlanta, GA
- Emory University Hospital Midtown · Atlanta, GA
- Emory University Hospital/Winship Cancer Institute · Atlanta, GA
- Grady Health System · Atlanta, GA
- Augusta University Medical Center · Augusta, GA
- Emory Johns Creek Hospital · Johns Creek, GA
Idaho · 6
- Saint Alphonsus Cancer Care Center-Boise · Boise, ID
- Saint Alphonsus Cancer Care Center-Caldwell · Caldwell, ID
- Kootenai Health - Coeur d'Alene · Coeur d'Alene, ID
- Saint Alphonsus Cancer Care Center-Nampa · Nampa, ID
- Kootenai Clinic Cancer Services - Post Falls · Post Falls, ID
- Kootenai Clinic Cancer Services - Sandpoint · Sandpoint, ID
Illinois · 29
- Illinois CancerCare-Bloomington · Bloomington, IL
- Illinois CancerCare-Canton · Canton, IL
- Illinois CancerCare-Carthage · Carthage, IL
- Alliance for Clinical Trials in Oncology · Chicago, IL
- University of Illinois · Chicago, IL
- Carle at The Riverfront · Danville, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Illinois CancerCare-Dixon · Dixon, IL
- Carle Physician Group-Effingham · Effingham, IL
- Crossroads Cancer Center · Effingham, IL
- Illinois CancerCare-Eureka · Eureka, IL
- Illinois CancerCare-Galesburg · Galesburg, IL
- Illinois CancerCare-Kewanee Clinic · Kewanee, IL
- Illinois CancerCare-Macomb · Macomb, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- SSM Health Good Samaritan · Mount Vernon, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- Illinois CancerCare-Ottawa Clinic · Ottawa, IL
- Illinois CancerCare-Pekin · Pekin, IL
- Illinois CancerCare-Peoria · Peoria, IL
- Illinois CancerCare-Peru · Peru, IL
- Illinois CancerCare-Princeton · Princeton, IL
- Memorial Hospital East · Shiloh, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Springfield Clinic · Springfield, IL
- Springfield Memorial Hospital · Springfield, IL
- Carle Cancer Center · Urbana, IL
- Illinois CancerCare - Washington · Washington, IL
Indiana · 8
- Northwest Cancer Center - Crown Point · Crown Point, IN
- Northwest Oncology LLC · Dyer, IN
- Northwest Cancer Center - Hobart · Hobart, IN
- Saint Mary Medical Center · Hobart, IN
- Saint Catherine Hospital · Indianapolis, IN
- The Community Hospital · Munster, IN
- Women's Diagnostic Center - Munster · Munster, IN
- Northwest Cancer Center - Valparaiso · Valparaiso, IN
Iowa · 15
- Mary Greeley Medical Center · Ames, IA
- McFarland Clinic - Ames · Ames, IA
- UI Health Care Mission Cancer and Blood - Ankeny Clinic · Ankeny, IA
- Saint Anthony Regional Hospital · Carroll, IA
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic · Clive, IA
- Broadlawns Medical Center · Des Moines, IA
- Iowa Methodist Medical Center · Des Moines, IA
- Mercy Medical Center - Des Moines · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Des Moines Clinic · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Laurel Clinic · Des Moines, IA
- McFarland Clinic - Trinity Cancer Center · Fort Dodge, IA
- UI Healthcare Mission Cancer and Blood - Fort Dodge · Fort Dodge, IA
- University of Iowa/Holden Comprehensive Cancer Center · Iowa City, IA
- McFarland Clinic - Marshalltown · Marshalltown, IA
- UI Health Care Mission Cancer and Blood - Waukee Clinic · Waukee, IA
Kansas · 9
- HaysMed · Hays, KS
- University of Kansas Cancer Center · Kansas City, KS
- Lawrence Memorial Hospital · Lawrence, KS
- The University of Kansas Cancer Center - Olathe · Olathe, KS
- University of Kansas Cancer Center-Overland Park · Overland Park, KS
- Freeman Physician Group of Pittsburg · Pittsburg, KS
- Salina Regional Health Center · Salina, KS
- University of Kansas Health System Saint Francis Campus · Topeka, KS
- University of Kansas Hospital-Westwood Cancer Center · Westwood, KS
Kentucky · 2
- The James Graham Brown Cancer Center at University of Louisville · Louisville, KY
- UofL Health Medical Center Northeast · Louisville, KY
Michigan · 29
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor · Ann Arbor, MI
- McLaren Cancer Institute-Bay City · Bay City, MI
- Trinity Health IHA Medical Group Hematology Oncology - Brighton · Brighton, MI
- Trinity Health Medical Center - Brighton · Brighton, MI
- Trinity Health IHA Medical Group Hematology Oncology - Canton · Canton, MI
- Trinity Health Medical Center - Canton · Canton, MI
- Chelsea Hospital · Chelsea, MI
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital · Chelsea, MI
- McLaren Cancer Institute-Clarkston · Clarkston, MI
- Wayne State University/Karmanos Cancer Institute · Detroit, MI
- Corewell Health Farmington Hills Hospital · Farmington Hills, MI
- Weisberg Cancer Treatment Center · Farmington Hills, MI
- Cancer Hematology Centers - Flint · Flint, MI
- Genesys Hurley Cancer Institute · Flint, MI
- Hurley Medical Center · Flint, MI
- McLaren Cancer Institute-Flint · Flint, MI
- University of Michigan Health - Sparrow Lansing · Lansing, MI
- McLaren Cancer Institute-Lapeer Region · Lapeer, MI
- Trinity Health Saint Mary Mercy Livonia Hospital · Livonia, MI
- Henry Ford Saint John Hospital - Macomb Medical · Macomb, MI
- McLaren Cancer Institute-Central Michigan · Mount Pleasant, MI
- McLaren Cancer Institute-Northern Michigan · Petoskey, MI
- Trinity Health Saint Joseph Mercy Oakland Hospital · Pontiac, MI
- Corewell Health William Beaumont University Hospital · Royal Oak, MI
- MyMichigan Medical Center Saginaw · Saginaw, MI
- MyMichigan Medical Center Tawas · Tawas City, MI
- Corewell Health Beaumont Troy Hospital · Troy, MI
- Huron Gastroenterology PC · Ypsilanti, MI
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus · Ypsilanti, MI
Minnesota · 16
- Sanford Joe Lueken Cancer Center · Bemidji, MN
- Essentia Health Saint Joseph's Medical Center · Brainerd, MN
- Mercy Hospital · Coon Rapids, MN
- Essentia Health - Deer River Clinic · Deer River, MN
- Essentia Health Cancer Center · Duluth, MN
- Essentia Health Hibbing Clinic · Hibbing, MN
- Saint John's Hospital - Healtheast · Maplewood, MN
- Abbott-Northwestern Hospital · Minneapolis, MN
- Hennepin County Medical Center · Minneapolis, MN
- Coborn Cancer Center at Saint Cloud Hospital · Saint Cloud, MN
- Park Nicollet Clinic - Saint Louis Park · Saint Louis Park, MN
- Regions Hospital · Saint Paul, MN
- United Hospital · Saint Paul, MN
- Essentia Health Sandstone · Sandstone, MN
- Essentia Health Virginia Clinic · Virginia, MN
- Minnesota Oncology Hematology PA-Woodbury · Woodbury, MN
Missouri · 11
- Saint Francis Medical Center · Cape Girardeau, MO
- Saint Luke's Hospital · Chesterfield, MO
- Siteman Cancer Center at Saint Peters Hospital · City of Saint Peters, MO
- Siteman Cancer Center at West County Hospital · Creve Coeur, MO
- Kansas City Veterans Affairs Medical Center · Kansas City, MO
- University Health Truman Medical Center · Kansas City, MO
- University of Kansas Cancer Center - Briarcliff · Kansas City, MO
- University of Kansas Cancer Center - North · Kansas City, MO
- University of Kansas Cancer Center - Lee's Summit · Lee's Summit, MO
- CoxHealth South Hospital · Springfield, MO
- Mercy Hospital Springfield · Springfield, MO
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.