A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)
NCT05920356
This study is recruiting at 26 US sites in 14 states, according to its ClinicalTrials.gov record last updated .
Summary
The primary objectives are to compare progression-free survival (PFS) and overall survival (OS) in participants who receive sotorasib with platinum doublet chemotherapy versus participants who receive pembrolizumab with platinum doublet chemotherapy.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Non-Small Cell Lung Cancer (NSCLC)
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 to 100 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Amgen
- Last updated on ClinicalTrials.gov
- October 13, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
California · 1
- Sansum Clinic · Santa Barbara, CA
Delaware · 1
- Medical Oncology Hematology Consultants Helen F Graham Cancer Center · Newark, DE
Florida · 4
- Boca Raton Clinical Research Coral Springs · Coral Springs, FL
- Regis Clinical Research LLC · Miami, FL
- Florida Clinical Trials Group Plantation · Plantation, FL
- Florida Clinical Trials Group Tamarac · Tamarac, FL
Illinois · 2
- University of Illinois Chicago · Chicago, IL
- Illinois Cancer Specialists · Niles, IL
Massachusetts · 1
- Reliant Medical Group Inc · Worcester, MA
New Mexico · 1
- University of New Mexico Cancer Center · Albuquerque, NM
North Carolina · 3
- Messino Cancer Centers Asheville · Asheville, NC
- Duke University Medical Center · Durham, NC
- FirstHealth Cancer Center · Pinehurst, NC
Ohio · 1
- Dayton Physician's Network · Dayton, OH
Pennsylvania · 2
- Alliance Cancer Specialists - Media · Media, PA
- Guthrie Medical Group · Sayre, PA
South Carolina · 2
- Medical University of South Carolina · Florence, SC
- Medical University of South Carolina Health Lancaster Medical Center · Lancaster, SC
Tennessee · 3
- Regional One Health · Memphis, TN
- Sarah Cannon Research Institute · Nashville, TN
- United States Oncology Regulatory Affairs Corporate Office · Nashville, TN
Texas · 3
- Oncology Consultants PA · Houston, TX
- University of Texas MD Anderson Cancer Center · Houston, TX
- US Oncology Research Investigational Products Center · Irving, TX
Washington · 1
- Vista Oncology Inc PS · Olympia, WA
Wisconsin · 1
- Mercyhealth · Janesville, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.