AWARE: Management of ADHD in Autism Spectrum Disorder
NCT05916339
This study is recruiting at 10 US sites in 7 states, according to its ClinicalTrials.gov record last updated .
Summary
This study is a pragmatic clinical trial examining the comparative effectiveness of two stimulant medications (methylphenidate and amphetamine) in the treatment of ADHD in children and adolescents with autism. Using a sequential, multiple assignment randomization trial (SMART) design the study will not only assess these two medications but also the role of an increasingly popular class of ADHD medication, the alpha-2 agonists.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- ADHD
- Autism Spectrum Disorder
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 4
- Ages
- 4 to 17 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Daniel Coury
- Last updated on ClinicalTrials.gov
- October 29, 2025
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
California · 2
- University of California, Irvine · Irvine, CA
- Children's Hospital Los Angeles · Los Angeles, CA
Maine · 1
- Maine Medical Center · Portland, ME
Massachusetts · 1
- Massachusetts General Hospital Lurie Center for Autism · Boston, MA
New York · 1
- University of Rochester · Rochester, NY
Ohio · 2
- Cincinnati Children's Hospital Medical Center · Cincinnati, OH
- Nationwide Children's Hospital · Columbus, OH
Pennsylvania · 2
- Children's Hospital of Philadelphia · Philadelphia, PA
- University of Pittsburgh · Pittsburgh, PA
Virginia · 1
- University of Virginia · Charlottesville, VA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.