The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation
NCT05836987
This study is recruiting at 84 US sites in 29 states, according to its ClinicalTrials.gov record last updated .
Summary
REACT-AF is a multicenter prospective, randomized, open-label, blinded endpoint (PROBE design), controlled trial comparing the current Standard Of Care (SOC) of continuous Direct Oral Anticoagulation (DOAC) use versus time-delimited (1 month) DOAC guided by an AF-sensing Smart Watch (AFSW) in participants with a history of paroxysmal or persistent Atrial Fibrillation (AF) and low-to-moderate stroke risk.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Atrial Fibrillation
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 22 to 85 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Johns Hopkins University
- Last updated on ClinicalTrials.gov
- October 14, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 1
- Banner University · Phoenix, AZ
California · 5
- University of California Los Angeles (UCLA Health) · Los Angeles, CA
- University of Southern California - Keck School of Medicine · Los Angeles, CA
- UC Davis Health · Sacramento, CA
- Scripps Health · San Diego, CA
- Stanford University · Stanford, CA
Colorado · 2
- University of Colorado · Aurora, CO
- South Denver Cardiology Associates, P.C. · Littleton, CO
District of Columbia · 1
- St. Elizabeth's Medical Center · Washington D.C., DC
Florida · 5
- BayCare Health Systems · Clearwater, FL
- University of Florida · Gainesville, FL
- Mayo Clinic · Jacksonville, FL
- University of Miami - Leonard S. Miller SOM · Miami, FL
- Baycare Health Systems Clearwater · Winter Haven, FL
Georgia · 2
- Emory University · Atlanta, GA
- Georgia Arrhythmia Consultants and Research Institute · Warner Robins, GA
Illinois · 8
- Loyola University Chicago · Chicago, IL
- Northwestern University · Chicago, IL
- Rush University Medical Center · Chicago, IL
- University of Chicago · Chicago, IL
- University of Illinois Chicago · Chicago, IL
- Alexian Brothers Health System · Elk Grove Village, IL
- NorthShore University HealthSystem · Evanston, IL
- Midwest Cardiovascular Institute · Naperville, IL
Indiana · 1
- Ascension St. Vincent · Indianapolis, IN
Iowa · 1
- University of Iowa Hospitals and Clinics · Iowa City, IA
Maine · 1
- Maine Medical Partners MaineHealth Cardiology · Scarborough, ME
Maryland · 1
- Johns Hopkins Univeristy · Baltimore, MD
Massachusetts · 7
- Beth Israel Deaconess Medical Center · Boston, MA
- BMC - Brighton · Boston, MA
- Boston Medical Center · Boston, MA
- Brigham and Women's Hospital · Boston, MA
- Mass General Hospital · Boston, MA
- Tufts Medical Center · Boston, MA
- Lahey Hospital & Medical Center · Burlington, MA
Michigan · 5
- Henry Ford Health · Detroit, MI
- Corewell Health (Former Spectrum Health) · Grand Rapids, MI
- Trinity Health Grand Rapids/Mercy Health · Grand Rapids, MI
- William Beaumont Hospital · Royal Oak, MI
- Trinity Health Michigan Heart - Ann Arbor · Ypsilanti, MI
Minnesota · 3
- Hennepin Healthcare Research Institute · Minneapolis, MN
- Minneapolis Heart Institute Foundation · Minneapolis, MN
- University of Minnesota · Minneapolis, MN
Missouri · 1
- Washington University School of Medicine · St Louis, MO
New Jersey · 4
- Advanced Heart and Vascular Institute of Hunterdon · Flemington, NJ
- Hackensack Meridian Health · Hackensack, NJ
- Rutgers, the State University of New Jersey · Piscataway, NJ
- The Valley Hospital, Inc. · Ridgewood, NJ
New Mexico · 1
- University of New Mexico Health Sciences Center · Albuquerque, NM
New York · 9
- University at Buffalo · Buffalo, NY
- Columbia University Medical Center · New York, NY
- NYU Langone Health · New York, NY
- Weill Medical College of Cornell University · New York, NY
- NewYork Presbyterian - Queens · Queens, NY
- Staten Island University Hospital-Northwell Health · Staten Island, NY
- Stony Brook University · Stony Brook, NY
- Westchester Medical Center · Valhalla, NY
- White Plains Hospital · White Plains, NY
North Carolina · 2
- University of North Carolina · Chapel Hill, NC
- Wake Forest Baptist Health · Winston-Salem, NC
Ohio · 5
- The Lindner Center for Research and Education at The Christ Hospital · Cincinnati, OH
- University of Cincinnati College of Medicine · Cincinnati, OH
- Ohio State University Medical Center · Columbus, OH
- OhioHealth Research Institute · Columbus, OH
- Wooster Community Hospital · Wooster, OH
Oklahoma · 1
- University of Oklahoma Health Sciences Center · Oklahoma City, OK
Pennsylvania · 3
- Thomas Jefferson University · Philadelphia, PA
- Allegheny Singer Research Institute · Pittsburgh, PA
- Penn State Health Medical Group Berks Cardiology · Wyomissing, PA
Rhode Island · 1
- Rhode Island Hospital · Providence, RI
South Carolina · 2
- Medical University of South Carolina · Charleston, SC
- MUSC Health Heart and Vascular · Columbia, SC
Texas · 5
- Texas Cardiac Arrhythmia Research Foundation · Austin, TX
- University of Texas Southwestern Medical Center · Dallas, TX
- Baylor College of Medicine · Houston, TX
- Houston Methodist Hospital · Houston, TX
- University of Texas Health Science Center at Houston · Houston, TX
Utah · 1
- University of Utah · Salt Lake City, UT
Virginia · 3
- University of Virginia · Charlottesville, VA
- James River Cardiology · Richmond, VA
- Virginia Commonwealth University · Richmond, VA
Washington · 1
- St. Joseph Medical Center Tacoma · Tacoma, WA
Wisconsin · 2
- University of Wisconsin · Madison, WI
- Medical College of Wisconsin Froedtert Hospital · Milwaukee, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.