Incremental Hemodialysis: The TwoPlus Trial
NCT05828823
This study is recruiting at 10 US sites in 8 states, according to its ClinicalTrials.gov record last updated .
Summary
This study is to prospectively compare clinical effectiveness between clinically- matched incremental hemodialysis and conventional hemodialysis in patients with incident kidney dysfunction requiring dialysis and residual kidney function. The study will enroll 350 patients on chronic hemodialysis and 140 caregivers of enrolled patients. Patients will be randomized in 1:1 ratio to either incremental start hemodialysis or conventional hemodialysis. Caregivers will be followed along with patients for an average period of 2 years post randomization.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- End-Stage Kidney Disease
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Not applicable
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Wake Forest University Health Sciences
- Last updated on ClinicalTrials.gov
- August 6, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Florida · 1
- University of Florida · Jacksonville, FL
Georgia · 1
- Emory University · Atlanta, GA
Maryland · 1
- Johns Hopkins University School of Medicine (JHUSM) · Baltimore, MD
Massachusetts · 1
- Massachusetts General Hospital · Boston, MA
Mississippi · 1
- University of Mississippi Medical Center · Jackson, MS
New York · 2
- Renal Research Institute (RRI) · New York, NY
- Northwell Health · Queens, NY
North Carolina · 2
- University of North Carolina Chapel Hill · Chapel Hill, NC
- Atrium Health Wake Forest Baptist · Winston-Salem, NC
Virginia · 1
- University of Virginia (UVA) · Charlottesville, VA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.