A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis
NCT05646381
This study is recruiting at 33 US sites in 14 states, according to its ClinicalTrials.gov record last updated .
Summary
The purpose of this study is to evaluate the efficacy, safety and tolerability of pelacarsen (TQJ230) administered subcutaneously once monthly compared to placebo in slowing the progression of calcific aortic valve stenosis.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Aortic Stenosis
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2
- Ages
- 50 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Novartis Pharmaceuticals
- Last updated on ClinicalTrials.gov
- June 23, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- Heart Center Research Llc · Huntsville, AL
California · 7
- Cardiovascular Res Found · Beverly Hills, CA
- National Heart Institute · Beverly Hills, CA
- Flourish Clinical Resrch Covin · Covina, CA
- Valley Clinical Trials · Northridge, CA
- Stanford University Medical Center · Palo Alto, CA
- University Of California San Diego · San Diego, CA
- UC San Francisco Medical Center · San Francisco, CA
Florida · 3
- Nova Clinical Research LLC · Bradenton, FL
- Flourish Res Acq LLC North Miami · Miami, FL
- Inpatient Research Clinical LLC · Miami Lakes, FL
Kansas · 1
- Midwest Heart and Vascular Spec · Overland Park, KS
Massachusetts · 5
- Brigham and Womens Hosp Harvard Med School · Boston, MA
- Brigham and Womens Hosp Harvard Med School · Boston, MA
- Massachusetts General Hospital · Boston, MA
- Massachusetts General Hospital · Boston, MA
- Tufts Medical Center · Boston, MA
Michigan · 4
- Henry Ford Hospital · Detroit, MI
- Henry Ford Hospital · Detroit, MI
- AA Medical Research Center · Flint, MI
- William Beaumont Hospital · Royal Oak, MI
Minnesota · 1
- University Of Minnesota · Minneapolis, MN
New Jersey · 1
- Overlook Medical Center · Summit, NJ
New York · 3
- Capital Cardiology Associates · Albany, NY
- Icahn School of Med at Mt Sinai · New York, NY
- Strong Memorial Hospital · Rochester, NY
North Carolina · 1
- Wake Forest University Baptist Medical Center · Winston-Salem, NC
Ohio · 1
- Lindner Ctr At The Christ Hosp · Cincinnati, OH
Pennsylvania · 1
- Perelman School of Medicine · Philadelphia, PA
Texas · 2
- Orion Medical · Houston, TX
- Texas Heart Institute · Houston, TX
Virginia · 2
- Virginia Heart · Falls Church, VA
- Carient Heart and Vascular · Manassas, VA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.