Adjuvant Therapy in POLE-Mutated and p53-Wildtype/NSMP Early Stage Endometrial Cancer RAINBO BLUE & TAPER
NCT05640999
This study is recruiting at 76 US sites in 29 states, according to its ClinicalTrials.gov record last updated .
Summary
This protocol tests de-escalated adjuvant treatment in patients with POLE-mutated or p53wt/NSMP (p53 wildtype/no specific molecular profile) early-stage endometrial cancer (EC). Patients may be enrolled in one of two sub-studies EN10.A/RAINBO BLUE: POLE-mutated EC EN10.B/TAPER: p53 wildtype / NSMP EC
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Endometrial Cancer
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2
- Ages
- 18 years and older
- Sex
- Female
- Healthy volunteers
- Not accepted
- Sponsor
- Canadian Cancer Trials Group
- Last updated on ClinicalTrials.gov
- October 14, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alaska · 1
- Alaska Womens Cancer Care · Anchorage, AK
Arizona · 1
- University of Arizona Cancer Center · Tucson, AZ
California · 3
- Cedars-Sinai Medical Center · Los Angeles, CA
- Huntington Memorial Hospital · Pasadena, CA
- Sutter Medical Center Sacramento · Sacramento, CA
Colorado · 2
- UCHealth University of Colorado Hospital · Aurora, CO
- AdventHealth Porter · Denver, CO
Florida · 11
- UM Sylvester Comprehensive Cancer Center at · Deerfield Beach, FL
- UM Sylvester Comprehensive Cancer Center at Doral · Doral, FL
- University of Florida · Gainesville, FL
- University of Miami School of Medicine · Miami, FL
- University of Miami Sylvester · North Miami, FL
- UM Sylvester Comprehensive Cancer Center · Plantation, FL
- First Physicians Group-Sarasota · Sarasota, FL
- Florida Cancer Specialists - Sarasota Downtown · Sarasota, FL
- Sarasota Memorial Health Care Centre · Sarasota, FL
- Sarasota Memorial Hospital · Sarasota, FL
- Florida Cancer Specialists - Venice Pinebrook · Venice, FL
Georgia · 6
- Emory Saint Josephs Hospital · Atlanta, GA
- Emory University Hospital Midtown · Atlanta, GA
- Emory University Hospital Winship Cancer Institute · Atlanta, GA
- Grady Health System · Atlanta, GA
- Piedmont Hospital · Atlanta, GA
- Emory Decatur Hospital · Decatur, GA
Illinois · 3
- Northwestern University · Chicago, IL
- Northwestern Medicine Orland Park · Orland Park, IL
- Northwestern Medicine Cancer Center Warrenville · Warrenville, IL
Indiana · 1
- Ascension Saint Vincent Indianapolis Hospital · Indianapolis, IN
Kentucky · 2
- Norton Hospital Pavilion and Medical Campus · Louisville, KY
- Norton Suburban Hospital and Medical Campus · Louisville, KY
Louisiana · 1
- University Medical Center New Orleans · New Orleans, LA
Massachusetts · 3
- Massachusetts General Hospital Cancer Center · Boston, MA
- Baystate Medical Center · Springfield, MA
- UMass Memorial Medical Centre · Worcester, MA
Minnesota · 1
- Mercy Hospital · Coon Rapids, MN
Missouri · 1
- Washington University School of Medicine · St Louis, MO
Nebraska · 1
- Nebraska Methodist Hospital · Omaha, NE
Nevada · 1
- Womens Cancer Center of Nevada · Las Vegas, NV
New Jersey · 1
- Sidney Kimmel Cancer Center Washington Township · Sewell, NJ
New York · 7
- Roswell Park Cancer Institute · Buffalo, NY
- Mount Sinai Chelsea · New York, NY
- Mount Sinai Hospital · New York, NY
- Upstate Cancer Center Radiation Oncology at Oswego · Oswego, NY
- State University of New York · Syracuse, NY
- Upstate Cancer Center at Hill Radiation Oncology · Syracuse, NY
- Upstate Cancer Center at Verona · Verona, NY
North Carolina · 3
- UNC Lineberger Comprehensive Cancer Center · Chapel Hill, NC
- Duke University Medical Center · Durham, NC
- Duke Womens Cancer Care Raleigh · Raleigh, NC
Ohio · 7
- UHHS-Chagrin Highlands Medical Center · Beachwood, OH
- Geauga Hospital · Chardon, OH
- Case Western Reserve University · Cleveland, OH
- Ohio State University Comprehensive · Columbus, OH
- UH Seidman Cancer Center · Mentor, OH
- University Hospitals Parma Medical Center · Parma, OH
- UH Seidman Cancer Center · Westlake, OH
Oklahoma · 1
- University of Oklahoma Health Sciences Center · Oklahoma City, OK
Oregon · 2
- Providence Portland Medical Centre · Portland, OR
- Providence Saint Vincent Medical Center · Portland, OR
Pennsylvania · 5
- Penn State Milton S Hershey Medical Center · Hershey, PA
- Paoli Memorial Hospital · Paoli, PA
- Thomas Jefferson University · Philadelphia, PA
- Asplundh Cancer Pavilion · Willow Grove, PA
- Lankenau Medical Center · Wynnewood, PA
Rhode Island · 1
- Women and Infants Hospital · Providence, RI
Texas · 1
- M.D. Anderson Cancer Center · Houston, TX
Utah · 3
- Farmington Health Centre · Farmington, UT
- Huntsman Cancer Institute University of Utah · Salt Lake City, UT
- University of Utah Sugarhouse Health Centre · Salt Lake City, UT
Vermont · 2
- University of Vermont and State Agricultural College · Burlington, VT
- University of Vermont Medical Center · Burlington, VT
Virginia · 2
- University of Virginia Cancer Center · Charlottesville, VA
- Virginia Commonwealth University · Richmond, VA
Washington · 1
- Swedish Medical Center First Hill · Seattle, WA
Wisconsin · 2
- Saint Vincent Hospital Cancer Center Green Bay · Green Bay, WI
- Medical College of Wisconsin · Milwaukee, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.