Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma
NCT05633615
This study is recruiting at 89 US sites in 27 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase II trial tests whether mosunetuzumab and/or polatuzumab vedotin helps benefit patients who have received chemotherapy (fludarabine and cyclophosphamide) followed by chimeric antigen receptor (CAR) T-cell therapy (tisagenlecleucel, axicabtagene ciloleucel, or lisocabtagene maraleucel) for diffuse large B-cell lymphoma that has come back (recurrent) or that does not respond to treatment (refractory) or grade IIIb follicular lymphoma. Mosunetuzumab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Diffuse Large B-Cell Lymphoma
- Grade 3b Follicular Lymphoma
- Primary Mediastinal (Thymic) Large B-Cell Lymphoma
- Recurrent Diffuse Large B-Cell Lymphoma
- Refractory Diffuse Large B-Cell Lymphoma
- Transformed Follic Lymph to Diff Large B-Cell Lymphoma
- Transformed Marg Zone Lymph to Diff Large B-Cell Lymphoma
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- SWOG Cancer Research Network
- Last updated on ClinicalTrials.gov
- October 15, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 2
- Banner University Medical Center - Tucson · Tucson, AZ
- University of Arizona Cancer Center-North Campus · Tucson, AZ
Arkansas · 4
- Highlands Oncology Group - Fayetteville · Fayetteville, AR
- University of Arkansas for Medical Sciences · Little Rock, AR
- Highlands Oncology Group - Rogers · Rogers, AR
- Highlands Oncology Group · Springdale, AR
California · 5
- UC Irvine Health Cancer Center-Newport · Costa Mesa, CA
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care · Irvine, CA
- UCI Health Laguna Hills · Laguna Hills, CA
- UC Irvine Health/Chao Family Comprehensive Cancer Center · Orange, CA
- UCSF Medical Center-Parnassus · San Francisco, CA
Florida · 1
- UF Health Cancer Institute - Gainesville · Gainesville, FL
Georgia · 2
- Emory Saint Joseph's Hospital · Atlanta, GA
- Emory University Hospital/Winship Cancer Institute · Atlanta, GA
Idaho · 5
- Saint Luke's Cancer Institute - Boise · Boise, ID
- Saint Luke's Cancer Institute - Fruitland · Fruitland, ID
- Saint Luke's Cancer Institute - Meridian · Meridian, ID
- Saint Luke's Cancer Institute - Nampa · Nampa, ID
- Saint Luke's Cancer Institute - Twin Falls · Twin Falls, ID
Illinois · 3
- University of Chicago Comprehensive Cancer Center · Chicago, IL
- University of Illinois · Chicago, IL
- Loyola University Medical Center · Maywood, IL
Iowa · 1
- University of Iowa/Holden Comprehensive Cancer Center · Iowa City, IA
Kansas · 3
- University of Kansas Cancer Center · Kansas City, KS
- University of Kansas Cancer Center-Overland Park · Overland Park, KS
- University of Kansas Hospital-Westwood Cancer Center · Westwood, KS
Kentucky · 2
- The James Graham Brown Cancer Center at University of Louisville · Louisville, KY
- UofL Health Medical Center Northeast · Louisville, KY
Louisiana · 2
- LSU Health Baton Rouge-North Clinic · Baton Rouge, LA
- Our Lady of the Lake Physician Group · Baton Rouge, LA
Maryland · 2
- Johns Hopkins University/Sidney Kimmel Cancer Center · Baltimore, MD
- University of Maryland/Greenebaum Cancer Center · Baltimore, MD
Michigan · 18
- Bronson Battle Creek · Battle Creek, MI
- Henry Ford Macomb Hospital-Clinton Township · Clinton Township, MI
- Henry Ford Medical Center-Fairlane · Dearborn, MI
- Henry Ford Hospital · Detroit, MI
- Wayne State University/Karmanos Cancer Institute · Detroit, MI
- Weisberg Cancer Treatment Center · Farmington Hills, MI
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital · Grand Rapids, MI
- Allegiance Health · Jackson, MI
- Bronson Methodist Hospital · Kalamazoo, MI
- West Michigan Cancer Center · Kalamazoo, MI
- Corewell Health Lakeland Hospitals - Niles Hospital · Niles, MI
- Henry Ford Medical Center-Columbus · Novi, MI
- Corewell Health Reed City Hospital · Reed City, MI
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center · Saint Joseph, MI
- Munson Medical Center · Traverse City, MI
- Henry Ford West Bloomfield Hospital · West Bloomfield, MI
- Henry Ford Wyandotte Hospital · Wyandotte, MI
- University of Michigan Health - West · Wyoming, MI
New Hampshire · 1
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center · Lebanon, NH
New York · 4
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center · New York, NY
- NYP/Weill Cornell Medical Center · New York, NY
- University of Rochester · Rochester, NY
- Wilmot Cancer Institute at Webster · Webster, NY
North Carolina · 4
- Carolinas Medical Center/Levine Cancer Institute · Charlotte, NC
- Atrium Health Cabarrus/LCI-Concord · Concord, NC
- Duke University Medical Center · Durham, NC
- Wake Forest University Health Sciences · Winston-Salem, NC
North Dakota · 2
- Sanford Broadway Medical Center · Fargo, ND
- Sanford Roger Maris Cancer Center · Fargo, ND
Ohio · 1
- Case Western Reserve University · Cleveland, OH
Oklahoma · 1
- University of Oklahoma Health Sciences Center · Oklahoma City, OK
Oregon · 5
- Providence Newberg Medical Center · Newberg, OR
- Providence Willamette Falls Medical Center · Oregon City, OR
- Oregon Health and Science University · Portland, OR
- Providence Portland Medical Center · Portland, OR
- Providence Saint Vincent Medical Center · Portland, OR
Pennsylvania · 3
- Geisinger Medical Center · Danville, PA
- University of Pennsylvania/Abramson Cancer Center · Philadelphia, PA
- Geisinger Wyoming Valley/Henry Cancer Center · Wilkes-Barre, PA
South Carolina · 8
- Prisma Health Cancer Institute - Spartanburg · Boiling Springs, SC
- Medical University of South Carolina · Charleston, SC
- Prisma Health Cancer Institute - Easley · Easley, SC
- Prisma Health Cancer Institute - Butternut · Greenville, SC
- Prisma Health Cancer Institute - Eastside · Greenville, SC
- Prisma Health Cancer Institute - Faris · Greenville, SC
- Prisma Health Cancer Institute - Greer · Greer, SC
- Prisma Health Cancer Institute - Seneca · Seneca, SC
Tennessee · 1
- Baptist Memorial Hospital and Cancer Center-Memphis · Memphis, TN
Vermont · 3
- University of Vermont and State Agricultural College · Burlington, VT
- University of Vermont Medical Center · Burlington, VT
- Dartmouth Cancer Center - North · Saint Johnsbury, VT
Virginia · 1
- VCU Massey Comprehensive Cancer Center · Richmond, VA
Washington · 1
- Swedish Medical Center-First Hill · Seattle, WA
Wisconsin · 4
- University of Wisconsin Carbone Cancer Center - Eastpark Medical Center · Madison, WI
- University of Wisconsin Carbone Cancer Center - University Hospital · Madison, WI
- Medical College of Wisconsin · Milwaukee, WI
- Froedtert and MCW Moorland Reserve Health Center · New Berlin, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.