Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment
NCT05561387
This study is recruiting at 387 US sites in 35 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase III trial compares three-drug induction regimens followed by double-or single-drug maintenance therapy for the treatment of newly diagnosed multiple myeloma in patients who are not receiving a stem cell transplant and are considered frail or intermediate-fit based on age, comorbidities, and functional status. Treatment for multiple myeloma includes initial treatment (induction) which is the first treatment a patient receives for cancer followed by ongoing treatment (maintenance) which is given after initial treatment to help keep the cancer from coming back.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Plasma Cell Myeloma
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- Any age
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- SWOG Cancer Research Network
- Last updated on ClinicalTrials.gov
- June 10, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alaska · 8
- Alaska Breast Care and Surgery LLC · Anchorage, AK
- Alaska Oncology and Hematology LLC · Anchorage, AK
- Alaska Women's Cancer Care · Anchorage, AK
- Anchorage Associates in Radiation Medicine · Anchorage, AK
- Anchorage Oncology Centre · Anchorage, AK
- Anchorage Radiation Therapy Center · Anchorage, AK
- Katmai Oncology Group · Anchorage, AK
- Providence Alaska Medical Center · Anchorage, AK
Arizona · 1
- Cancer Center at Saint Joseph's · Phoenix, AZ
Arkansas · 3
- Mercy Hospital Fort Smith · Fort Smith, AR
- CARTI Cancer Center · Little Rock, AR
- University of Arkansas for Medical Sciences · Little Rock, AR
California · 18
- Mission Hope Medical Oncology - Arroyo Grande · Arroyo Grande, CA
- Providence Saint Joseph Medical Center/Disney Family Cancer Center · Burbank, CA
- Marshall Cancer Center · Cameron Park, CA
- Mercy Cancer Center - Carmichael · Carmichael, CA
- Mercy San Juan Medical Center · Carmichael, CA
- Mercy Cancer Center - Elk Grove · Elk Grove, CA
- Fremont - Rideout Cancer Center · Marysville, CA
- Mercy UC Davis Cancer Center · Merced, CA
- Providence Queen of The Valley · Napa, CA
- Mercy Cancer Center - Rocklin · Rocklin, CA
- Mercy Cancer Center - Sacramento · Sacramento, CA
- University of California Davis Comprehensive Cancer Center · Sacramento, CA
- Pacific Central Coast Health Center-San Luis Obispo · San Luis Obispo, CA
- Mission Hope Medical Oncology - Santa Maria · Santa Maria, CA
- Providence Medical Foundation - Santa Rosa · Santa Rosa, CA
- Providence Santa Rosa Memorial Hospital · Santa Rosa, CA
- Gene Upshaw Memorial Tahoe Forest Cancer Center · Truckee, CA
- Woodland Memorial Hospital · Woodland, CA
Colorado · 9
- Rocky Mountain Regional VA Medical Center · Aurora, CO
- Penrose-Saint Francis Healthcare · Colorado Springs, CO
- Rocky Mountain Cancer Centers-Penrose · Colorado Springs, CO
- Saint Francis Cancer Center · Colorado Springs, CO
- Mercy Medical Center · Durango, CO
- Southwest Oncology PC · Durango, CO
- Saint Anthony Hospital · Lakewood, CO
- Longmont United Hospital · Longmont, CO
- Saint Mary Corwin Medical Center · Pueblo, CO
Connecticut · 14
- Smilow Cancer Hospital-Derby Care Center · Derby, CT
- Smilow Cancer Hospital Care Center-Fairfield · Fairfield, CT
- Smilow Cancer Hospital Care Center at Glastonbury · Glastonbury, CT
- Smilow Cancer Hospital Care Center at Greenwich · Greenwich, CT
- Smilow Cancer Hospital Care Center - Guilford · Guilford, CT
- Smilow Cancer Hospital Care Center at Saint Francis · Hartford, CT
- Smilow Cancer Center/Yale-New Haven Hospital · New Haven, CT
- Yale University · New Haven, CT
- Yale-New Haven Hospital North Haven Medical Center · North Haven, CT
- Smilow Cancer Hospital Care Center at Long Ridge · Stamford, CT
- Smilow Cancer Hospital-Torrington Care Center · Torrington, CT
- Smilow Cancer Hospital Care Center-Trumbull · Trumbull, CT
- Smilow Cancer Hospital-Waterbury Care Center · Waterbury, CT
- Smilow Cancer Hospital Care Center - Waterford · Waterford, CT
Florida · 3
- Holy Cross Hospital · Fort Lauderdale, FL
- Mayo Clinic in Florida · Jacksonville, FL
- Jupiter Medical Center · Jupiter, FL
Idaho · 5
- Saint Luke's Cancer Institute - Boise · Boise, ID
- Saint Luke's Cancer Institute - Fruitland · Fruitland, ID
- Saint Luke's Cancer Institute - Meridian · Meridian, ID
- Saint Luke's Cancer Institute - Nampa · Nampa, ID
- Saint Luke's Cancer Institute - Twin Falls · Twin Falls, ID
Illinois · 44
- Saint Anthony's Health · Alton, IL
- Rush - Copley Medical Center · Aurora, IL
- Illinois CancerCare-Bloomington · Bloomington, IL
- Saint Joseph Medical Center · Bloomington, IL
- Loyola Center for Health at Burr Ridge · Burr Ridge, IL
- Illinois CancerCare-Canton · Canton, IL
- Memorial Hospital of Carbondale · Carbondale, IL
- SIH Cancer Institute · Carterville, IL
- Illinois CancerCare-Carthage · Carthage, IL
- Centralia Oncology Clinic · Centralia, IL
- Saint Mary's Hospital · Centralia, IL
- Carle at The Riverfront · Danville, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Illinois CancerCare-Dixon · Dixon, IL
- Carle Physician Group-Effingham · Effingham, IL
- Crossroads Cancer Center · Effingham, IL
- Illinois CancerCare-Eureka · Eureka, IL
- Illinois CancerCare-Galesburg · Galesburg, IL
- Western Illinois Cancer Treatment Center · Galesburg, IL
- Edward Hines Jr VA Hospital · Hines, IL
- Loyola Medicine Homer Glen · Homer Glen, IL
- Illinois CancerCare-Kewanee Clinic · Kewanee, IL
- Illinois CancerCare-Macomb · Macomb, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- Loyola University Medical Center · Maywood, IL
- Marjorie Weinberg Cancer Center at Loyola-Gottlieb · Melrose Park, IL
- Good Samaritan Regional Health Center · Mount Vernon, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- HSHS Saint Elizabeth's Hospital · O'Fallon, IL
- Illinois CancerCare-Ottawa Clinic · Ottawa, IL
- Illinois CancerCare-Pekin · Pekin, IL
- Illinois CancerCare-Peoria · Peoria, IL
- Methodist Medical Center of Illinois · Peoria, IL
- Illinois CancerCare-Peru · Peru, IL
- Valley Radiation Oncology · Peru, IL
- Illinois CancerCare-Princeton · Princeton, IL
- Memorial Medical Center · Springfield, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Springfield Clinic · Springfield, IL
- Carle Cancer Center · Urbana, IL
- The Carle Foundation Hospital · Urbana, IL
- Illinois CancerCare - Washington · Washington, IL
- Rush-Copley Healthcare Center · Yorkville, IL
Indiana · 11
- IU Health North Hospital · Carmel, IN
- Northwest Cancer Center - Main Campus · Crown Point, IN
- Northwest Oncology LLC · Dyer, IN
- Northwest Cancer Center - Hobart · Hobart, IN
- Saint Mary Medical Center · Hobart, IN
- Indiana University/Melvin and Bren Simon Cancer Center · Indianapolis, IN
- Saint Catherine Hospital · Indianapolis, IN
- The Community Hospital · Munster, IN
- Women's Diagnostic Center - Munster · Munster, IN
- Reid Health · Richmond, IN
- Northwest Cancer Center - Valparaiso · Valparaiso, IN
Iowa · 10
- Mission Cancer and Blood - Ankeny · Ankeny, IA
- University of Iowa Healthcare Cancer Services Quad Cities · Bettendorf, IA
- Physicians' Clinic of Iowa PC · Cedar Rapids, IA
- Medical Oncology and Hematology Associates-West Des Moines · Clive, IA
- Mercy Cancer Center-West Lakes · Clive, IA
- Greater Regional Medical Center · Creston, IA
- Mercy Medical Center - Des Moines · Des Moines, IA
- Mission Cancer and Blood - Laurel · Des Moines, IA
- University of Iowa/Holden Comprehensive Cancer Center · Iowa City, IA
- Mercy Medical Center-West Lakes · West Des Moines, IA
Kansas · 2
- Central Care Cancer Center - Garden City · Garden City, KS
- Central Care Cancer Center - Great Bend · Great Bend, KS
Kentucky · 7
- Flaget Memorial Hospital · Bardstown, KY
- Commonwealth Cancer Center-Corbin · Corbin, KY
- Saint Joseph Hospital · Lexington, KY
- Saint Joseph Hospital East · Lexington, KY
- Saint Joseph Radiation Oncology Resource Center · Lexington, KY
- Saint Joseph London · London, KY
- Saint Joseph Mount Sterling · Mount Sterling, KY
Maryland · 1
- Greater Baltimore Medical Center · Baltimore, MD
Michigan · 14
- Saint Joseph Mercy Hospital · Ann Arbor, MI
- Bronson Battle Creek · Battle Creek, MI
- Saint Joseph Mercy Brighton · Brighton, MI
- Trinity Health IHA Medical Group Hematology Oncology - Brighton · Brighton, MI
- Saint Joseph Mercy Canton · Canton, MI
- Trinity Health IHA Medical Group Hematology Oncology - Canton · Canton, MI
- Caro Cancer Center · Caro, MI
- Saint Joseph Mercy Chelsea · Chelsea, MI
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital · Chelsea, MI
- Hematology Oncology Consultants-Clarkston · Clarkston, MI
- Newland Medical Associates-Clarkston · Clarkston, MI
- Ascension Saint John Hospital · Detroit, MI
- Genesee Cancer and Blood Disease Treatment Center · Flint, MI
- Genesee Hematology Oncology PC · Flint, MI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.