A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation
NCT05552157
This study is recruiting at 12 US sites in 12 states, according to its ClinicalTrials.gov record last updated .
Summary
The purpose is to evaluate the biomarker effect, safety, and tolerability of investigational study drugs in participants who are known to have an Alzheimer's disease (AD)-causing mutation. Stage 1 will determine if treatment with the study drug prevents or slows the rate of amyloid beta (Aβ) pathological disease accumulation demonstrated by Aβ positron emission tomography (PET) imaging.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Alzheimers Disease
- Dementia
- Alzheimers Disease, Familial
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2/3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Sponsor
- Washington University School of Medicine
- Last updated on ClinicalTrials.gov
- July 27, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- University of Alabama in Birmingham · Birmingham, AL
California · 1
- University of California San Diego Medical Center · La Jolla, CA
Connecticut · 1
- Yale University School of Medicine · New Haven, CT
Georgia · 1
- Emory University · Atlanta, GA
Illinois · 1
- Advocate Lutheran General Hospital · Park Ridge, IL
Indiana · 1
- Indiana University School of Medicine · Indianapolis, IN
Missouri · 1
- Washington University in St. Louis · St Louis, MO
New York · 1
- New York University Medical Center · New York, NY
Pennsylvania · 1
- University of Pittsburgh · Pittsburgh, PA
Rhode Island · 1
- Butler Hospital · Providence, RI
Texas · 1
- Kerwin Research and Memory Center · Dallas, TX
Washington · 1
- University of Washington · Seattle, WA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.