Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS)
NCT05508971
This study is recruiting at 6 US sites in 5 states, according to its ClinicalTrials.gov record last updated .
Summary
The overall objective of this randomized clinical trial is to test the effectiveness of a personalized approach to the surgical treatment of OSA in children with Down syndrome (DS).The estimated prevalence of obstructive sleep apnea (OSA) in children with DS ranges from 45-83%, compared to 1-6% in the general pediatric population. Untreated OSA in children has been associated with daytime sleepiness, cognitive or behavioral problems, and cardiovascular complications, all which are common in children with DS.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Obstructive Sleep Apnea
- Down Syndrome
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Not applicable
- Ages
- 2 to 17 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Oregon Health and Science University
- Last updated on ClinicalTrials.gov
- September 11, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Colorado · 1
- Colorado Children's Hospital · Aurora, CO
Michigan · 1
- University of Michigan · Ann Arbor, MI
Oregon · 1
- Oregon Health and Science University · Portland, OR
Texas · 2
- UT Southwestern Medical Center · Dallas, TX
- Texas Children's Hospital · Houston, TX
Virginia · 1
- EVMS Medical School · Norfolk, VA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.