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cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

NCT05366881

This study is recruiting at 16 US sites in 11 states, according to its ClinicalTrials.gov record last updated .

Summary

This is an observational case-control study to train and validate a genome-wide methylome enrichment platform to detect multiple cancer types and to differentiate amongst cancer types. The cancers included in this study are brain, breast, bladder, cervical, colorectal, endometrial, esophageal, gastric, head and neck, hepatobiliary, leukemia, lung, lymphoma, multiple myeloma, ovarian, pancreatic, prostate, renal, sarcoma, and thyroid. These cancers were selected based on their prevalence and mortality to maximize impact on clinical care.

Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov

Conditions studied

  • Brain Cancer
  • Breast Cancer
  • Bladder Cancer
  • Cervical Cancer
  • Colorectal Cancer
  • Endometrial Cancer
  • Esophageal Cancer
  • Stomach Cancer
  • Head and Neck Cancer
  • Hepatobiliary Cancer
  • Leukemia
  • Lung Cancer
  • Lymphoma
  • Multiple Myeloma
  • Ovarian Cancer
  • Pancreatic Cancer
  • Prostate Cancer
  • Renal Cancer
  • Sarcoma
  • Thyroid Cancer

Eligibility basics and study details

Study type
Observational
Phase
Not applicable
Ages
40 years and older
Sex
All
Healthy volunteers
Accepted
Sponsor
Adela, Inc
Last updated on ClinicalTrials.gov
January 20, 2026

These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.

US recruiting sites

California · 1

  • City of Hope · Duarte, CA

Florida · 1

  • Miami Cancer Institute · Miami, FL

Georgia · 1

  • North Georgia Health System · Gainesville, GA

Indiana · 1

  • Baptist Floyd · New Albany, IN

Kentucky · 3

  • Baptist Corbin · Corbin, KY
  • Baptist Hardin · Elizabethtown, KY
  • Baptist Lexington · Lexington, KY

Minnesota · 2

  • Allina Health Cancer Institute · Minneapolis, MN
  • Mayo Clinic · Rochester, MN

Ohio · 1

  • Cleveland Clinic · Cleveland, OH

Oregon · 1

  • Oregon Health Sciences University · Portland, OR

South Carolina · 2

  • Medical University of South Carolina · Charleston, SC
  • McLeod Health · Florence, SC

Tennessee · 2

  • Baptist (BHMCC) · Memphis, TN
  • Vanderbilt-Ingram Cancer Center · Nashville, TN

Texas · 1

  • Elligo Health Research, Inc. · Austin, TX

Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.