Abatacept in Immune Checkpoint Inhibitor Myocarditis
NCT05335928
This study is recruiting at 28 US sites in 21 states, according to its ClinicalTrials.gov record last updated .
Summary
The primary aim is to test whether abatacept, as compared to placebo, is associated with a reduction in major adverse cardiac events (MACE) among participants hospitalized with myocarditis secondary to an immune checkpoint inhibitor (ICI). The primary outcome, MACE, is a composite of first occurrence of cardiovascular death, non-fatal sudden cardiac arrest, cardiogenic shock, significant ventricular arrythmias, significant bradyarrythmias, or incident heart failure.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Myocarditis Acute
- Cancer
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Massachusetts General Hospital
- Last updated on ClinicalTrials.gov
- August 20, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
California · 2
- Cedars-Sinai Medical Center · Los Angeles, CA
- University of California Los Angeles · Los Angeles, CA
District of Columbia · 1
- MedStar Health Research Institute, Georgetown University · Washington D.C., DC
Florida · 1
- Moffitt Cancer Center · Tampa, FL
Illinois · 1
- University of Chicago · Chicago, IL
Indiana · 1
- Franciscan Health · Indianapolis, IN
Kansas · 1
- University of Kansas Medical Center · Kansas City, KS
Kentucky · 1
- University of Kentucky · Lexington, KY
Maine · 1
- Maine Health · Portland, ME
Maryland · 1
- Johns Hopkins · Baltimore, MD
Massachusetts · 4
- Beth Israel Deaconess Medical Center · Boston, MA
- Boston Medical Center · Boston, MA
- Brigham and Women's Hospital · Boston, MA
- Massachusetts General Hospital · Boston, MA
Michigan · 1
- University of Michigan · Ann Arbor, MI
Minnesota · 1
- Mayo Clinic · Rochester, MN
New Jersey · 1
- Robert Wood Johnson University Hospital · New Brunswick, NJ
New York · 2
- Columbia University Irving Medical Center · New York, NY
- Memorial Sloan Kettering Cancer Center · New York, NY
North Carolina · 1
- University of North Carolina Chapel Hill · Chapel Hill, NC
Ohio · 1
- Cleveland Clinic · Cleveland, OH
Pennsylvania · 3
- Lehigh Valley Health Network · Bethlehem, PA
- University of Pennsylvania · Philadelphia, PA
- Allegheny-Singer Research Institution · Pittsburgh, PA
Texas · 1
- University of Texas Southwestern · Dallas, TX
Utah · 1
- University of Utah · Salt Lake City, UT
West Virginia · 1
- University of West Virginia · Morgantown, WV
Wisconsin · 1
- Aurora St Luke's Medical Center · Milwaukee, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.