Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial
NCT05327686
This study is recruiting at 280 US sites in 32 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase II trial tests whether the addition of radiation to the primary tumor, typically given with stereotactic ablative radiation therapy (SABR), in combination with standard of care immunotherapy improves outcomes in patients with renal cell cancer that is not recommended for surgery and has spread from where it first started (primary site) to other places in the body (metastatic). Radiation therapy uses high energy photons to kill tumor cells and shrink tumors.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Metastatic Renal Cell Carcinoma
- Stage III Renal Cell Cancer AJCC v8
- Stage IV Renal Cell Cancer AJCC v8
- Unresectable Renal Cell Carcinoma
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- NRG Oncology
- Last updated on ClinicalTrials.gov
- September 18, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 2
- Kingman Regional Medical Center · Kingman, AZ
- Mayo Clinic Hospital in Arizona · Phoenix, AZ
Arkansas · 1
- University of Arkansas for Medical Sciences · Little Rock, AR
California · 19
- PCR Oncology · Arroyo Grande, CA
- Tower Cancer Research Foundation · Beverly Hills, CA
- Mills-Peninsula Medical Center · Burlingame, CA
- UC San Diego Health System - Encinitas · Encinitas, CA
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care · Irvine, CA
- UC San Diego Moores Cancer Center · La Jolla, CA
- Cedars-Sinai Medical Center · Los Angeles, CA
- Los Angeles General Medical Center · Los Angeles, CA
- USC / Norris Comprehensive Cancer Center · Los Angeles, CA
- Memorial Medical Center · Modesto, CA
- UC Irvine Health/Chao Family Comprehensive Cancer Center · Orange, CA
- Sutter Cancer Centers Radiation Oncology Services-Roseville · Roseville, CA
- Sutter Roseville Medical Center · Roseville, CA
- Sutter Medical Center Sacramento · Sacramento, CA
- UC San Diego Medical Center - Hillcrest · San Diego, CA
- UCSF Medical Center-Mission Bay · San Francisco, CA
- Mills Health Center · San Mateo, CA
- Ridley-Tree Cancer Center · Santa Barbara, CA
- Sutter Pacific Medical Foundation · Santa Rosa, CA
Colorado · 8
- UCHealth University of Colorado Hospital · Aurora, CO
- UCHealth - Cherry Creek · Denver, CO
- Cancer Care and Hematology-Fort Collins · Fort Collins, CO
- Poudre Valley Hospital · Fort Collins, CO
- UCHealth Greeley Hospital · Greeley, CO
- UCHealth Highlands Ranch Hospital · Highlands Ranch, CO
- UCHealth Lone Tree Health Center · Lone Tree, CO
- Medical Center of the Rockies · Loveland, CO
Delaware · 7
- Beebe Medical Center · Lewes, DE
- Beebe South Coastal Health Campus · Millville, DE
- Christiana Care Health System-Christiana Hospital · Newark, DE
- Helen F Graham Cancer Center · Newark, DE
- Medical Oncology Hematology Consultants PA · Newark, DE
- Beebe Health Campus · Rehoboth Beach, DE
- Christiana Care Health System-Wilmington Hospital · Wilmington, DE
Florida · 6
- Mount Sinai Comprehensive Cancer Center at Aventura · Aventura, FL
- Memorial Regional Hospital/Joe DiMaggio Children's Hospital · Hollywood, FL
- Mayo Clinic in Florida · Jacksonville, FL
- Miami Cancer Institute · Miami, FL
- Mount Sinai Medical Center · Miami Beach, FL
- Memorial Hospital West · Pembroke Pines, FL
Idaho · 3
- Saint Alphonsus Cancer Care Center-Boise · Boise, ID
- Saint Alphonsus Cancer Care Center-Caldwell · Caldwell, ID
- Saint Alphonsus Cancer Care Center-Nampa · Nampa, ID
Illinois · 28
- Centralia Oncology Clinic · Centralia, IL
- Northwestern University · Chicago, IL
- University of Chicago Comprehensive Cancer Center · Chicago, IL
- Carle at The Riverfront · Danville, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Northwestern Medicine Cancer Center Kishwaukee · DeKalb, IL
- Carle Physician Group-Effingham · Effingham, IL
- Crossroads Cancer Center · Effingham, IL
- Northwestern Medicine Cancer Center Delnor · Geneva, IL
- Northwestern Medicine Glenview Outpatient Center · Glenview, IL
- Northwestern Medicine Grayslake Outpatient Center · Grayslake, IL
- Ingalls Memorial Hospital · Harvey, IL
- Northwestern Medicine Lake Forest Hospital · Lake Forest, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- UC Comprehensive Cancer Center at Silver Cross · New Lenox, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- HSHS Saint Elizabeth's Hospital · O'Fallon, IL
- Northwestern Medicine Oak Brook · Oak Brook, IL
- Northwestern Medicine Orland Park · Orland Park, IL
- University of Chicago Medicine-Orland Park · Orland Park, IL
- UW Health Carbone Cancer Center Rockford · Rockford, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Springfield Clinic · Springfield, IL
- Springfield Memorial Hospital · Springfield, IL
- Carle Cancer Center · Urbana, IL
- The Carle Foundation Hospital · Urbana, IL
- Northwestern Medicine Cancer Center Warrenville · Warrenville, IL
Indiana · 3
- UChicago Medicine Northwest Indiana · Crown Point, IN
- Franciscan Health Indianapolis · Indianapolis, IN
- Franciscan Health Mooresville · Mooresville, IN
Iowa · 8
- Mary Greeley Medical Center · Ames, IA
- McFarland Clinic - Ames · Ames, IA
- UI Health Care Mission Cancer and Blood - Ankeny Clinic · Ankeny, IA
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic · Clive, IA
- Iowa Methodist Medical Center · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Des Moines Clinic · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Laurel Clinic · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Waukee Clinic · Waukee, IA
Louisiana · 3
- Louisiana Hematology Oncology Associates LLC · Baton Rouge, LA
- Mary Bird Perkins Cancer Center · Baton Rouge, LA
- Mary Bird Perkins Cancer Center - Metairie · Metairie, LA
Massachusetts · 3
- Brigham and Women's Hospital · Boston, MA
- Dana-Farber Cancer Institute · Boston, MA
- Massachusetts General Hospital Cancer Center · Boston, MA
Michigan · 15
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor · Ann Arbor, MI
- University of Michigan Rogel Cancer Center · Ann Arbor, MI
- Trinity Health IHA Medical Group Hematology Oncology - Brighton · Brighton, MI
- Trinity Health Medical Center - Brighton · Brighton, MI
- Trinity Health IHA Medical Group Hematology Oncology - Canton · Canton, MI
- Trinity Health Medical Center - Canton · Canton, MI
- Chelsea Hospital · Chelsea, MI
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital · Chelsea, MI
- Corewell Health Dearborn Hospital · Dearborn, MI
- Corewell Health Farmington Hills Hospital · Farmington Hills, MI
- University of Michigan Health - Sparrow Lansing · Lansing, MI
- Trinity Health Saint Mary Mercy Livonia Hospital · Livonia, MI
- Corewell Health William Beaumont University Hospital · Royal Oak, MI
- Corewell Health Beaumont Troy Hospital · Troy, MI
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus · Ypsilanti, MI
Minnesota · 20
- Sanford Joe Lueken Cancer Center · Bemidji, MN
- Essentia Health Saint Joseph's Medical Center · Brainerd, MN
- Minnesota Oncology Hematology PA-Chaska · Chaska, MN
- Essentia Health - Deer River Clinic · Deer River, MN
- Essentia Health Cancer Center · Duluth, MN
- Essentia Health Saint Mary's Medical Center · Duluth, MN
- Miller-Dwan Hospital · Duluth, MN
- Fairview Southdale Hospital · Edina, MN
- Essentia Health Hibbing Clinic · Hibbing, MN
- Fairview Clinics and Surgery Center Maple Grove · Maple Grove, MN
- Abbott-Northwestern Hospital · Minneapolis, MN
- Hennepin County Medical Center · Minneapolis, MN
- University of Minnesota/Masonic Cancer Center · Minneapolis, MN
- Mayo Clinic in Rochester · Rochester, MN
- Regions Hospital · Saint Paul, MN
- Essentia Health Sandstone · Sandstone, MN
- Saint Francis Regional Medical Center · Shakopee, MN
- Lakeview Hospital · Stillwater, MN
- Essentia Health Virginia Clinic · Virginia, MN
- Ridgeview Medical Center · Waconia, MN
Missouri · 5
- Saint Francis Medical Center · Cape Girardeau, MO
- MU Health - University Hospital/Ellis Fischel Cancer Center · Columbia, MO
- Mercy Hospital Springfield · Springfield, MO
- Mercy Hospital Saint Louis · St Louis, MO
- Mercy Hospital South · St Louis, MO
Nebraska · 3
- Nebraska Medicine-Bellevue · Bellevue, NE
- Nebraska Medicine-Village Pointe · Omaha, NE
- University of Nebraska Medical Center · Omaha, NE
New Jersey · 5
- Memorial Sloan Kettering Basking Ridge · Basking Ridge, NJ
- Cooper Hospital University Medical Center · Camden, NJ
- Memorial Sloan Kettering Monmouth · Middletown, NJ
- Memorial Sloan Kettering Bergen · Montvale, NJ
- Cooper CyberKnife Center · Mount Laurel, NJ
New Mexico · 2
- Lovelace Medical Center-Saint Joseph Square · Albuquerque, NM
- Lovelace Radiation Oncology · Albuquerque, NM
New York · 9
- Northwell Health Imbert Cancer Center · Bay Shore, NY
- Memorial Sloan Kettering Commack · Commack, NY
- Glens Falls Hospital · Glens Falls, NY
- Northwell Health Cancer Institute at Huntington · Greenlawn, NY
- Memorial Sloan Kettering Westchester · Harrison, NY
- Northwell Health/Center for Advanced Medicine · Lake Success, NY
- Northern Westchester Hospital · Mount Kisco, NY
- Laura and Isaac Perlmutter Cancer Center at NYU Langone · New York, NY
- Lenox Hill Hospital · New York, NY
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.