Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma
NCT05304585
This study is recruiting at 164 US sites in 47 states, according to its ClinicalTrials.gov record last updated .
Summary
Rhabdomyosarcoma is a type of cancer that occurs in the soft tissues in the body. This phase III trial aims to maintain excellent outcomes in patients with very low risk rhabdomyosarcoma (VLR-RMS) while decreasing the burden of therapy using treatment with 24 weeks of vincristine and dactinomycin (VA) and examines the use of centralized molecular risk stratification in the treatment of rhabdomyosarcoma.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Embryonal Rhabdomyosarcoma
- Fusion-Negative Alveolar Rhabdomyosarcoma
- Spindle Cell/Sclerosing Rhabdomyosarcoma
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- Up to 21 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Children's Oncology Group
- Last updated on ClinicalTrials.gov
- August 25, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 2
- Children's Hospital of Alabama · Birmingham, AL
- USA Health Strada Patient Care Center · Mobile, AL
Arizona · 1
- Phoenix Childrens Hospital · Phoenix, AZ
Arkansas · 1
- Arkansas Children's Hospital · Little Rock, AR
California · 15
- Kaiser Permanente Downey Medical Center · Downey, CA
- Loma Linda University Medical Center · Loma Linda, CA
- Miller Children's and Women's Hospital Long Beach · Long Beach, CA
- Cedars-Sinai Medical Center · Los Angeles, CA
- Children's Hospital Los Angeles · Los Angeles, CA
- Mattel Children's Hospital UCLA · Los Angeles, CA
- Valley Children's Hospital · Madera, CA
- Kaiser Permanente-Oakland · Oakland, CA
- UCSF Benioff Children's Hospital Oakland · Oakland, CA
- Children's Hospital of Orange County · Orange, CA
- Lucile Packard Children's Hospital Stanford University · Palo Alto, CA
- University of California Davis Comprehensive Cancer Center · Sacramento, CA
- Naval Medical Center -San Diego · San Diego, CA
- Rady Children's Hospital - San Diego · San Diego, CA
- UCSF Medical Center-Mission Bay · San Francisco, CA
Colorado · 2
- Children's Hospital Colorado · Aurora, CO
- Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center · Denver, CO
Connecticut · 2
- Connecticut Children's Medical Center · Hartford, CT
- Yale University · New Haven, CT
Delaware · 1
- Alfred I duPont Hospital for Children · Wilmington, DE
District of Columbia · 2
- Children's National Medical Center · Washington D.C., DC
- MedStar Georgetown University Hospital · Washington D.C., DC
Florida · 14
- Broward Health Medical Center · Fort Lauderdale, FL
- Golisano Children's Hospital of Southwest Florida · Fort Myers, FL
- UF Health Cancer Institute - Gainesville · Gainesville, FL
- Memorial Regional Hospital/Joe DiMaggio Children's Hospital · Hollywood, FL
- Nemours Children's Clinic-Jacksonville · Jacksonville, FL
- Nicklaus Children's Hospital · Miami, FL
- University of Miami Miller School of Medicine-Sylvester Cancer Center · Miami, FL
- AdventHealth Orlando · Orlando, FL
- Arnold Palmer Hospital for Children · Orlando, FL
- Nemours Children's Hospital · Orlando, FL
- Nemours Children's Clinic - Pensacola · Pensacola, FL
- Johns Hopkins All Children's Hospital · St. Petersburg, FL
- Saint Joseph's Hospital/Children's Hospital-Tampa · Tampa, FL
- Saint Mary's Medical Center · West Palm Beach, FL
Georgia · 3
- Children's Healthcare of Atlanta - Arthur M Blank Hospital · Atlanta, GA
- Atrium Health Navicent · Macon, GA
- Memorial Health University Medical Center · Savannah, GA
Hawaii · 1
- Kapiolani Medical Center for Women and Children · Honolulu, HI
Idaho · 1
- Saint Luke's Cancer Institute - Boise · Boise, ID
Illinois · 8
- Lurie Children's Hospital-Chicago · Chicago, IL
- University of Chicago Comprehensive Cancer Center · Chicago, IL
- Loyola University Medical Center · Maywood, IL
- Advocate Children's Hospital-Oak Lawn · Oak Lawn, IL
- Advocate Children's Hospital-Park Ridge · Park Ridge, IL
- OSF Children's Hospital of Illinois · Peoria, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Northwestern Medicine Central DuPage Hospital · Winfield, IL
Indiana · 2
- Ascension Saint Vincent Indianapolis Hospital · Indianapolis, IN
- Riley Hospital for Children · Indianapolis, IN
Iowa · 2
- Blank Children's Hospital · Des Moines, IA
- University of Iowa/Holden Comprehensive Cancer Center · Iowa City, IA
Kansas · 1
- Wesley Medical Center · Wichita, KS
Kentucky · 2
- University of Kentucky/Markey Cancer Center · Lexington, KY
- Norton Children's Hospital · Louisville, KY
Louisiana · 2
- Children's Hospital New Orleans · New Orleans, LA
- Ochsner Medical Center Jefferson · New Orleans, LA
Maine · 1
- Maine Children's Cancer Program · Scarborough, ME
Maryland · 3
- Johns Hopkins University/Sidney Kimmel Cancer Center · Baltimore, MD
- Sinai Hospital of Baltimore · Baltimore, MD
- University of Maryland/Greenebaum Cancer Center · Baltimore, MD
Massachusetts · 3
- Dana-Farber Cancer Institute · Boston, MA
- Massachusetts General Hospital Cancer Center · Boston, MA
- UMass Memorial Medical Center - University Campus · Worcester, MA
Michigan · 5
- C S Mott Children's Hospital · Ann Arbor, MI
- Children's Hospital of Michigan · Detroit, MI
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital · Grand Rapids, MI
- Bronson Methodist Hospital · Kalamazoo, MI
- Corewell Health Children's · Royal Oak, MI
Minnesota · 3
- Children's Hospitals and Clinics of Minnesota - Minneapolis · Minneapolis, MN
- University of Minnesota/Masonic Cancer Center · Minneapolis, MN
- Mayo Clinic in Rochester · Rochester, MN
Mississippi · 1
- University of Mississippi Medical Center · Jackson, MS
Missouri · 4
- Children's Mercy Hospitals and Clinics · Kansas City, MO
- Cardinal Glennon Children's Medical Center · St Louis, MO
- Mercy Hospital Saint Louis · St Louis, MO
- Washington University School of Medicine · St Louis, MO
Nebraska · 2
- Children's Hospital and Medical Center of Omaha · Omaha, NE
- University of Nebraska Medical Center · Omaha, NE
Nevada · 3
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation · Las Vegas, NV
- Summerlin Hospital Medical Center · Las Vegas, NV
- Renown Regional Medical Center · Reno, NV
New Hampshire · 1
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center · Lebanon, NH
New Jersey · 5
- Hackensack University Medical Center · Hackensack, NJ
- Morristown Medical Center · Morristown, NJ
- Jersey Shore Medical Center · Neptune City, NJ
- Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital · New Brunswick, NJ
- Newark Beth Israel Medical Center · Newark, NJ
New Mexico · 1
- University of New Mexico Cancer Center · Albuquerque, NM
New York · 11
- Albany Medical Center · Albany, NY
- Roswell Park Cancer Institute · Buffalo, NY
- The Steven and Alexandra Cohen Children's Medical Center of New York · New Hyde Park, NY
- Laura and Isaac Perlmutter Cancer Center at NYU Langone · New York, NY
- Memorial Sloan Kettering Cancer Center · New York, NY
- Mount Sinai Hospital · New York, NY
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center · New York, NY
- University of Rochester · Rochester, NY
- State University of New York Upstate Medical University · Syracuse, NY
- Montefiore Medical Center - Moses Campus · The Bronx, NY
- New York Medical College · Valhalla, NY
North Carolina · 6
- UNC Lineberger Comprehensive Cancer Center · Chapel Hill, NC
- Carolinas Medical Center/Levine Cancer Institute · Charlotte, NC
- Novant Health Presbyterian Medical Center · Charlotte, NC
- Duke University Medical Center · Durham, NC
- East Carolina University · Greenville, NC
- Wake Forest University Health Sciences · Winston-Salem, NC
North Dakota · 1
- Sanford Broadway Medical Center · Fargo, ND
Ohio · 7
- Children's Hospital Medical Center of Akron · Akron, OH
- Cincinnati Children's Hospital Medical Center · Cincinnati, OH
- Cleveland Clinic Foundation · Cleveland, OH
- Rainbow Babies and Childrens Hospital · Cleveland, OH
- Nationwide Children's Hospital · Columbus, OH
- Dayton Children's Hospital · Dayton, OH
- ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital · Toledo, OH
Oklahoma · 1
- University of Oklahoma Health Sciences Center · Oklahoma City, OK
Oregon · 1
- Oregon Health and Science University · Portland, OR
Pennsylvania · 6
- Lehigh Valley Hospital-Cedar Crest · Allentown, PA
- Geisinger Medical Center · Danville, PA
- Penn State Children's Hospital · Hershey, PA
- Children's Hospital of Philadelphia · Philadelphia, PA
- Saint Christopher's Hospital for Children · Philadelphia, PA
- Children's Hospital of Pittsburgh of UPMC · Pittsburgh, PA
Rhode Island · 1
- Rhode Island Hospital · Providence, RI
South Carolina · 3
- Medical University of South Carolina · Charleston, SC
- Prisma Health Richland Hospital · Columbia, SC
- BI-LO Charities Children's Cancer Center · Greenville, SC
South Dakota · 1
- Sanford USD Medical Center - Sioux Falls · Sioux Falls, SD
Tennessee · 4
- East Tennessee Childrens Hospital · Knoxville, TN
- Saint Jude Children's Research Hospital · Memphis, TN
- The Children's Hospital at TriStar Centennial · Nashville, TN
- Vanderbilt University/Ingram Cancer Center · Nashville, TN
Texas · 14
- Dell Children's Medical Center of Central Texas · Austin, TX
- Driscoll Children's Hospital · Corpus Christi, TX
- Medical City Dallas Hospital · Dallas, TX
- UT Southwestern/Simmons Cancer Center-Dallas · Dallas, TX
- El Paso Children's Hospital · El Paso, TX
- Cook Children's Medical Center · Fort Worth, TX
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center · Houston, TX
- UT MD Anderson Cancer Center · Houston, TX
- Covenant Children's Hospital · Lubbock, TX
- UMC Cancer Center / UMC Health System · Lubbock, TX
- Children's Hospital of San Antonio · San Antonio, TX
- Methodist Children's Hospital of South Texas · San Antonio, TX
- University of Texas Health Science Center at San Antonio · San Antonio, TX
- Scott and White Memorial Hospital · Temple, TX
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.