Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion
NCT05245500
This study is recruiting at 22 US sites in 12 states, according to its ClinicalTrials.gov record last updated .
Summary
This is a Phase 1, open-label, multicenter, study of the safety, tolerability, PK, PD, and anti-tumor activity of MRTX1719 patients with advanced, unresectable or metastatic solid tumor malignancy with homozygous deletion of the MTAP gene.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Mesothelioma
- Non Small Cell Lung Cancer
- Malignant Peripheral Nerve Sheath Tumors
- Solid Tumor
- Pancreatic Adenocarcinoma
- Advanced Solid Tumor
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 1
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Bristol-Myers Squibb
- Last updated on ClinicalTrials.gov
- September 2, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 1
- Mayo Clinic · Phoenix, AZ
Colorado · 1
- Rocky Mountain Cancer Centers, LLP - Oncology · Lone Tree, CO
Florida · 2
- Mayo Clinic · Jacksonville, FL
- Sarah Cannon Research Institute at Florida Cancer Specialists · Orlando, FL
Massachusetts · 1
- Dana-Farber Cancer Institute · Brookline, MA
Michigan · 2
- The Cancer & Hematology Centers · Grand Rapids, MI
- Cancer and Hematology Centers of Western Michigan · Norton Shores, MI
Minnesota · 1
- Mayo Clinic · Rochester, MN
New Jersey · 1
- Rutgers Cancer Institute of New Jersey · New Brunswick, NJ
New York · 4
- Perlmutter Cancer Center at NYU Langone Hospital Long Island · Mineola, NY
- David H Koch, Memorial Sloan Kettering Cancer Center · New York, NY
- New york cancer and blood specialists - Oncology · Port Jefferson Station, NY
- New york cancer and blood specialists - Oncology · Port Jefferson Station, NY
North Carolina · 2
- University of North Carolina · Chapel Hill, NC
- University of North Carolina - Gastroenterology and Hepatology · Chapel Hill, NC
Tennessee · 1
- Vanderbilt - Ingram Cancer Center · Nashville, TN
Texas · 5
- Ut Southwestern · Dallas, TX
- Texas Oncology - DFW · Fort Worth, TX
- MDACC · Houston, TX
- South Texas Accelerated Research Therapeutics · San Antonio, TX
- Texas Oncology, P.A. - Oncology · Tyler, TX
Virginia · 1
- Virginia Cancer Specialists, PC · Fairfax, VA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.