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Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

NCT05235165

This study is recruiting at 202 US sites in 47 states, according to its ClinicalTrials.gov record last updated .

Summary

This phase III trial compares the effect of open thoracic surgery (thoracotomy) to thoracoscopic surgery (video-assisted thoracoscopic surgery or VATS) in treating patients with osteosarcoma that has spread to the lung (pulmonary metastases). Open thoracic surgery is a type of surgery done through a single larger incision (like a large cut) that goes between the ribs, opens up the chest, and removes the cancer. Thoracoscopy is a type of chest surgery where the doctor makes several small incisions and uses a small camera to help with removing the cancer.

Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov

Conditions studied

  • Metastatic Malignant Neoplasm in the Lung
  • Metastatic Osteosarcoma
  • Osteosarcoma

Eligibility basics and study details

Study type
Interventional
Phase
Phase 3
Ages
Up to 50 years
Sex
All
Healthy volunteers
Not accepted
Sponsor
Children's Oncology Group
Last updated on ClinicalTrials.gov
August 25, 2026

These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.

US recruiting sites

Alabama · 1

  • Children's Hospital of Alabama · Birmingham, AL

Alaska · 1

  • Providence Alaska Medical Center · Anchorage, AK

Arizona · 4

  • Kingman Regional Medical Center · Kingman, AZ
  • Banner Children's at Desert · Mesa, AZ
  • Phoenix Childrens Hospital · Phoenix, AZ
  • Banner University Medical Center - Tucson · Tucson, AZ

Arkansas · 1

  • Arkansas Children's Hospital · Little Rock, AR

California · 18

  • Kaiser Permanente-Anaheim · Anaheim, CA
  • PCR Oncology · Arroyo Grande, CA
  • Kaiser Permanente-Bellflower · Bellflower, CA
  • Kaiser Permanente Downey Medical Center · Downey, CA
  • Kaiser Permanente-Fontana · Fontana, CA
  • Loma Linda University Medical Center · Loma Linda, CA
  • Miller Children's and Women's Hospital Long Beach · Long Beach, CA
  • Cedars-Sinai Medical Center · Los Angeles, CA
  • Children's Hospital Los Angeles · Los Angeles, CA
  • Kaiser Permanente Los Angeles Medical Center · Los Angeles, CA
  • Valley Children's Hospital · Madera, CA
  • Kaiser Permanente-Oakland · Oakland, CA
  • Children's Hospital of Orange County · Orange, CA
  • Lucile Packard Children's Hospital Stanford University · Palo Alto, CA
  • University of California Davis Comprehensive Cancer Center · Sacramento, CA
  • Kaiser Permanente-San Diego Zion · San Diego, CA
  • Rady Children's Hospital - San Diego · San Diego, CA
  • UCSF Medical Center-Mission Bay · San Francisco, CA

Colorado · 2

  • Children's Hospital Colorado · Aurora, CO
  • Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center · Denver, CO

Connecticut · 3

  • Connecticut Children's Medical Center · Hartford, CT
  • Smilow Cancer Center/Yale-New Haven Hospital · New Haven, CT
  • Yale University · New Haven, CT

Delaware · 1

  • Alfred I duPont Hospital for Children · Wilmington, DE

District of Columbia · 1

  • Children's National Medical Center · Washington D.C., DC

Florida · 8

  • Golisano Children's Hospital of Southwest Florida · Fort Myers, FL
  • Nemours Children's Clinic-Jacksonville · Jacksonville, FL
  • Nicklaus Children's Hospital · Miami, FL
  • Arnold Palmer Hospital for Children · Orlando, FL
  • Nemours Children's Hospital · Orlando, FL
  • Johns Hopkins All Children's Hospital · St. Petersburg, FL
  • Saint Joseph's Hospital/Children's Hospital-Tampa · Tampa, FL
  • Tampa General Hospital · Tampa, FL

Georgia · 1

  • Children's Healthcare of Atlanta - Arthur M Blank Hospital · Atlanta, GA

Hawaii · 1

  • Kapiolani Medical Center for Women and Children · Honolulu, HI

Idaho · 1

  • Saint Luke's Cancer Institute - Boise · Boise, ID

Illinois · 6

  • Lurie Children's Hospital-Chicago · Chicago, IL
  • University of Chicago Comprehensive Cancer Center · Chicago, IL
  • University of Illinois · Chicago, IL
  • Loyola University Medical Center · Maywood, IL
  • OSF Children's Hospital of Illinois · Peoria, IL
  • Northwestern Medicine Central DuPage Hospital · Winfield, IL

Indiana · 1

  • Riley Hospital for Children · Indianapolis, IN

Iowa · 2

  • Blank Children's Hospital · Des Moines, IA
  • University of Iowa/Holden Comprehensive Cancer Center · Iowa City, IA

Kentucky · 2

  • University of Kentucky/Markey Cancer Center · Lexington, KY
  • Norton Children's Hospital · Louisville, KY

Louisiana · 2

  • Children's Hospital New Orleans · New Orleans, LA
  • Ochsner Medical Center Jefferson · New Orleans, LA

Maine · 2

  • Eastern Maine Medical Center · Bangor, ME
  • Maine Children's Cancer Program · Scarborough, ME

Maryland · 4

  • Johns Hopkins University/Sidney Kimmel Cancer Center · Baltimore, MD
  • Sinai Hospital of Baltimore · Baltimore, MD
  • University of Maryland/Greenebaum Cancer Center · Baltimore, MD
  • Walter Reed National Military Medical Center · Bethesda, MD

Massachusetts · 2

  • Dana-Farber Cancer Institute · Boston, MA
  • Massachusetts General Hospital Cancer Center · Boston, MA

Michigan · 19

  • C S Mott Children's Hospital · Ann Arbor, MI
  • University of Michigan Rogel Cancer Center · Ann Arbor, MI
  • Bronson Battle Creek · Battle Creek, MI
  • Children's Hospital of Michigan · Detroit, MI
  • Corewell Health Grand Rapids Hospitals - Butterworth Hospital · Grand Rapids, MI
  • Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital · Grand Rapids, MI
  • Trinity Health Grand Rapids Hospital · Grand Rapids, MI
  • Beacon Kalamazoo · Kalamazoo, MI
  • Beacon Kalamazoo Cancer Center · Kalamazoo, MI
  • Bronson Methodist Hospital · Kalamazoo, MI
  • West Michigan Cancer Center · Kalamazoo, MI
  • Trinity Health Muskegon Hospital · Muskegon, MI
  • Corewell Health Lakeland Hospitals - Niles Hospital · Niles, MI
  • Corewell Health Reed City Hospital · Reed City, MI
  • Corewell Health Children's · Royal Oak, MI
  • Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center · Saint Joseph, MI
  • Corewell Health Lakeland Hospitals - Saint Joseph Hospital · Saint Joseph, MI
  • Munson Medical Center · Traverse City, MI
  • University of Michigan Health - West · Wyoming, MI

Minnesota · 3

  • Children's Hospitals and Clinics of Minnesota - Minneapolis · Minneapolis, MN
  • University of Minnesota/Masonic Cancer Center · Minneapolis, MN
  • Mayo Clinic in Rochester · Rochester, MN

Mississippi · 1

  • University of Mississippi Medical Center · Jackson, MS

Missouri · 5

  • University of Missouri Children's Hospital · Columbia, MO
  • Children's Mercy Hospitals and Clinics · Kansas City, MO
  • Cardinal Glennon Children's Medical Center · St Louis, MO
  • Mercy Hospital Saint Louis · St Louis, MO
  • Washington University School of Medicine · St Louis, MO

Nebraska · 2

  • Children's Hospital and Medical Center of Omaha · Omaha, NE
  • University of Nebraska Medical Center · Omaha, NE

Nevada · 28

  • Carson Tahoe Regional Medical Center · Carson City, NV
  • Comprehensive Cancer Centers of Nevada - Henderson · Henderson, NV
  • Comprehensive Cancer Centers of Nevada-Horizon Ridge · Henderson, NV
  • Comprehensive Cancer Centers of Nevada-Southeast Henderson · Henderson, NV
  • Oncology Las Vegas - Henderson · Henderson, NV
  • Urology Specialists of Nevada - Green Valley · Henderson, NV
  • Alliance for Childhood Diseases/Cure 4 the Kids Foundation · Las Vegas, NV
  • Comprehensive Cancer Centers of Nevada · Las Vegas, NV
  • Comprehensive Cancer Centers of Nevada - Central Valley · Las Vegas, NV
  • Comprehensive Cancer Centers of Nevada - Northwest · Las Vegas, NV
  • Comprehensive Cancer Centers of Nevada - Town Center · Las Vegas, NV
  • Comprehensive Cancer Centers of Nevada-Summerlin · Las Vegas, NV
  • Hope Cancer Care of Nevada · Las Vegas, NV
  • Oncology Las Vegas - Tenaya · Las Vegas, NV
  • OptumCare Cancer Care at Charleston · Las Vegas, NV
  • OptumCare Cancer Care at Fort Apache · Las Vegas, NV
  • OptumCare Cancer Care at MountainView · Las Vegas, NV
  • Radiation Oncology Centers of Nevada Central · Las Vegas, NV
  • Radiation Oncology Centers of Nevada Southeast · Las Vegas, NV
  • Summerlin Hospital Medical Center · Las Vegas, NV
  • Sunrise Hospital and Medical Center · Las Vegas, NV
  • University Medical Center of Southern Nevada · Las Vegas, NV
  • Urology Specialists of Nevada - Central · Las Vegas, NV
  • Urology Specialists of Nevada - Northwest · Las Vegas, NV
  • Urology Specialists of Nevada - Southwest · Las Vegas, NV
  • Hope Cancer Care of Nevada-Pahrump · Pahrump, NV
  • Renown Regional Medical Center · Reno, NV
  • Saint Mary's Regional Medical Center · Reno, NV

New Hampshire · 1

  • Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center · Lebanon, NH

New Jersey · 5

  • Hackensack University Medical Center · Hackensack, NJ
  • Morristown Medical Center · Morristown, NJ
  • Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital · New Brunswick, NJ
  • Saint Peter's University Hospital · New Brunswick, NJ
  • Saint Joseph's Regional Medical Center · Paterson, NJ

New Mexico · 1

  • Presbyterian Hospital · Albuquerque, NM

New York · 14

  • Albany Medical Center · Albany, NY
  • Maimonides Medical Center · Brooklyn, NY
  • The Steven and Alexandra Cohen Children's Medical Center of New York · New Hyde Park, NY
  • Laura and Isaac Perlmutter Cancer Center at NYU Langone · New York, NY
  • Memorial Sloan Kettering Cancer Center · New York, NY
  • Mount Sinai Hospital · New York, NY
  • NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center · New York, NY
  • Stony Brook University Medical Center · Stony Brook, NY
  • State University of New York Upstate Medical University · Syracuse, NY
  • Children's Hospital at Montefiore · The Bronx, NY
  • Montefiore Medical Center - Moses Campus · The Bronx, NY
  • Montefiore Medical Center-Einstein Campus · The Bronx, NY
  • Montefiore Medical Center-Weiler Hospital · The Bronx, NY
  • New York Medical College · Valhalla, NY

North Carolina · 5

  • Mission Hospital · Asheville, NC
  • UNC Lineberger Comprehensive Cancer Center · Chapel Hill, NC
  • Duke University Medical Center · Durham, NC
  • East Carolina University · Greenville, NC
  • Wake Forest University Health Sciences · Winston-Salem, NC

North Dakota · 1

  • Sanford Broadway Medical Center · Fargo, ND

Ohio · 1

  • Children's Hospital Medical Center of Akron · Akron, OH

+52 more sites listed on ClinicalTrials.gov

Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.