Testing Nivolumab With or Without Ipilimumab in Deficient Mismatch Repair System (dMMR) Recurrent Endometrial Carcinoma
NCT05112601
This study is recruiting at 120 US sites in 27 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase II trial tests whether the combination of nivolumab and ipilimumab is better than nivolumab alone to shrink tumors in patients with deficient mismatch repair system (dMMR) endometrial carcinoma that has come back after a period of time during which the cancer could not be detected (recurrent). Deoxyribonucleic acid (DNA) mismatch repair (MMR) is a system for recognizing and repairing damaged DNA.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Endometrial Adenocarcinoma
- Endometrial Clear Cell Adenocarcinoma
- Endometrial Dedifferentiated Carcinoma
- Endometrial Endometrioid Adenocarcinoma
- Endometrial Mixed Cell Adenocarcinoma
- Endometrial Mucinous Adenocarcinoma
- Endometrial Undifferentiated Carcinoma
- Endometrioid Adenocarcinoma
- Recurrent Endometrial Carcinoma
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2
- Ages
- 18 years and older
- Sex
- Female
- Healthy volunteers
- Not accepted
- Sponsor
- National Cancer Institute (NCI)
- Last updated on ClinicalTrials.gov
- October 14, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- University of Alabama at Birmingham Cancer Center · Birmingham, AL
Georgia · 1
- Augusta University Medical Center · Augusta, GA
Idaho · 7
- Saint Luke's Cancer Institute - Boise · Boise, ID
- Kootenai Health - Coeur d'Alene · Coeur d'Alene, ID
- Saint Luke's Cancer Institute - Fruitland · Fruitland, ID
- Saint Luke's Cancer Institute - Meridian · Meridian, ID
- Saint Luke's Cancer Institute - Nampa · Nampa, ID
- Kootenai Clinic Cancer Services - Post Falls · Post Falls, ID
- Kootenai Clinic Cancer Services - Sandpoint · Sandpoint, ID
Illinois · 6
- Carle at The Riverfront · Danville, IL
- Carle Physician Group-Effingham · Effingham, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- Carle BroMenn Medical Center · Normal, IL
- Carle Cancer Institute Normal · Normal, IL
- Carle Cancer Center · Urbana, IL
Indiana · 9
- Northwest Cancer Center - Crown Point · Crown Point, IN
- Northwest Oncology LLC · Dyer, IN
- Northwest Cancer Center - Hobart · Hobart, IN
- Saint Mary Medical Center · Hobart, IN
- Indiana University/Melvin and Bren Simon Cancer Center · Indianapolis, IN
- Saint Catherine Hospital · Indianapolis, IN
- The Community Hospital · Munster, IN
- Women's Diagnostic Center - Munster · Munster, IN
- Northwest Cancer Center - Valparaiso · Valparaiso, IN
Iowa · 1
- University of Iowa/Holden Comprehensive Cancer Center · Iowa City, IA
Kentucky · 2
- The James Graham Brown Cancer Center at University of Louisville · Louisville, KY
- UofL Health Medical Center Northeast · Louisville, KY
Maine · 1
- MaineHealth Maine Medical Center- Scarborough · Scarborough, ME
Michigan · 10
- Bronson Battle Creek · Battle Creek, MI
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital · Grand Rapids, MI
- Bronson Methodist Hospital · Kalamazoo, MI
- West Michigan Cancer Center · Kalamazoo, MI
- Corewell Health Lakeland Hospitals - Niles Hospital · Niles, MI
- Corewell Health Reed City Hospital · Reed City, MI
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center · Saint Joseph, MI
- Corewell Health Lakeland Hospitals - Saint Joseph Hospital · Saint Joseph, MI
- Munson Medical Center · Traverse City, MI
- University of Michigan Health - West · Wyoming, MI
Minnesota · 14
- Mercy Hospital · Coon Rapids, MN
- Essentia Health - Deer River Clinic · Deer River, MN
- Essentia Health Cancer Center · Duluth, MN
- Miller-Dwan Hospital · Duluth, MN
- Fairview Southdale Hospital · Edina, MN
- Minnesota Oncology - Edina · Edina, MN
- Essentia Health Hibbing Clinic · Hibbing, MN
- Abbott-Northwestern Hospital · Minneapolis, MN
- Park Nicollet Clinic - Saint Louis Park · Saint Louis Park, MN
- Regions Hospital · Saint Paul, MN
- United Hospital · Saint Paul, MN
- Essentia Health Sandstone · Sandstone, MN
- Saint Francis Regional Medical Center · Shakopee, MN
- Essentia Health Virginia Clinic · Virginia, MN
Missouri · 2
- MU Health - University Hospital/Ellis Fischel Cancer Center · Columbia, MO
- Washington University School of Medicine · St Louis, MO
Montana · 8
- Community Hospital of Anaconda · Anaconda, MT
- Billings Clinic Cancer Center · Billings, MT
- Intermountain Health West End Clinic · Billings, MT
- Saint Vincent Frontier Cancer Center · Billings, MT
- Bozeman Health Deaconess Hospital · Bozeman, MT
- Benefis Sletten Cancer Institute · Great Falls, MT
- Logan Health Medical Center · Kalispell, MT
- Community Medical Center · Missoula, MT
Nebraska · 1
- Nebraska Methodist Hospital · Omaha, NE
Nevada · 1
- Women's Cancer Center of Nevada · Las Vegas, NV
New Mexico · 1
- University of New Mexico Cancer Center · Albuquerque, NM
New York · 3
- University of Rochester · Rochester, NY
- State University of New York Upstate Medical University · Syracuse, NY
- Wilmot Cancer Institute at Webster · Webster, NY
North Carolina · 2
- Duke University Medical Center · Durham, NC
- Duke Women's Cancer Care Raleigh · Raleigh, NC
North Dakota · 1
- Essentia Health Cancer Center-South University Clinic · Fargo, ND
Ohio · 11
- UHHS-Chagrin Highlands Medical Center · Beachwood, OH
- Miami Valley Hospital South · Centerville, OH
- Geauga Hospital · Chardon, OH
- Case Western Reserve University · Cleveland, OH
- Cleveland Clinic Cancer Center/Fairview Hospital · Cleveland, OH
- Cleveland Clinic Foundation · Cleveland, OH
- Ohio State University Comprehensive Cancer Center · Columbus, OH
- Hillcrest Hospital Cancer Center · Mayfield Heights, OH
- UH Seidman Cancer Center at Lake Health Mentor Campus · Mentor, OH
- University Hospitals Parma Medical Center · Parma, OH
- UH Seidman Cancer Center at Saint John Medical Center · Westlake, OH
Oklahoma · 1
- University of Oklahoma Health Sciences Center · Oklahoma City, OK
Oregon · 2
- Providence Portland Medical Center · Portland, OR
- Providence Saint Vincent Medical Center · Portland, OR
Pennsylvania · 24
- UPMC-Heritage Valley Health System Beaver · Beaver, PA
- UPMC Hillman Cancer Center at Butler Health System · Butler, PA
- UPMC Hillman Cancer Center - Passavant - Cranberry · Cranberry Township, PA
- UPMC Hillman Cancer Center Erie · Erie, PA
- UPMC Cancer Center at UPMC Horizon · Farrell, PA
- UPMC Cancer Centers - Arnold Palmer Pavilion · Greensburg, PA
- IRMC Cancer Center · Indiana, PA
- UPMC-Johnstown/John P. Murtha Regional Cancer Center · Johnstown, PA
- UPMC Cancer Center at UPMC McKeesport · McKeesport, PA
- UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion · Mechanicsburg, PA
- UPMC Hillman Cancer Center - Monroeville · Monroeville, PA
- UPMC Hillman Cancer Center in Coraopolis · Moon Township, PA
- UPMC Hillman Cancer Center - Part of Frick Hospital · Mount Pleasant, PA
- UPMC Cancer Center-Natrona Heights · Natrona Heights, PA
- UPMC Hillman Cancer Center - New Castle · New Castle, PA
- UPMC Hillman Cancer Center · Pittsburgh, PA
- UPMC-Magee Womens Hospital · Pittsburgh, PA
- UPMC-Mercy Hospital · Pittsburgh, PA
- UPMC-Passavant Hospital · Pittsburgh, PA
- UPMC-Saint Clair Hospital Cancer Center · Pittsburgh, PA
- UPMC-Saint Margaret · Pittsburgh, PA
- UPMC Cancer Center at UPMC Northwest · Seneca, PA
- UPMC Cancer Center-Washington · Washington, PA
- UPMC West Mifflin-Cancer Center Jefferson · West Mifflin, PA
Rhode Island · 1
- Women and Infants Hospital · Providence, RI
Texas · 3
- Parkland Memorial Hospital · Dallas, TX
- UT Southwestern/Simmons Cancer Center-Dallas · Dallas, TX
- UT Southwestern Clinical Center at Richardson/Plano · Richardson, TX
Virginia · 2
- University of Virginia Cancer Center · Charlottesville, VA
- Henrico Doctor's Hospital · Richmond, VA
Washington · 3
- Swedish Cancer Institute-Edmonds · Edmonds, WA
- Swedish Cancer Institute-Issaquah · Issaquah, WA
- Swedish Medical Center-First Hill · Seattle, WA
Wisconsin · 2
- Duluth Clinic Ashland · Ashland, WI
- Northwest Wisconsin Cancer Center · Ashland, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.