Evaluating the Addition of the Immunotherapy Drug Atezolizumab to Standard Chemotherapy Treatment for Advanced or Metastatic Neuroendocrine Carcinomas That Originate Outside the Lung
NCT05058651
This study is recruiting at 241 US sites in 32 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase II/III trial compares the effect of immunotherapy with atezolizumab in combination with standard chemotherapy with a platinum drug (cisplatin or carboplatin) and etoposide versus standard therapy alone for the treatment of poorly differentiated extrapulmonary (originated outside the lung) neuroendocrine cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) or that has spread from where it first started (primary site) to other places in the body (metastatic).
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Advanced Extrapulmonary Neuroendocrine Carcinoma
- Metastatic Extrapulmonary Neuroendocrine Carcinoma
- Recurrent Extrapulmonary Neuroendocrine Carcinoma
- Unresectable Extrapulmonary Neuroendocrine Carcinoma
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2/3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- National Cancer Institute (NCI)
- Last updated on ClinicalTrials.gov
- October 15, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 2
- Cancer Center at Saint Joseph's · Phoenix, AZ
- Mayo Clinic Hospital in Arizona · Phoenix, AZ
California · 36
- Kaiser Permanente-Anaheim · Anaheim, CA
- Sutter Auburn Faith Hospital · Auburn, CA
- Sutter Cancer Centers Radiation Oncology Services-Auburn · Auburn, CA
- Kaiser Permanente-Baldwin Park · Baldwin Park, CA
- Kaiser Permanente-Bellflower · Bellflower, CA
- Alta Bates Summit Medical Center-Herrick Campus · Berkeley, CA
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park · Cameron Park, CA
- Mercy Cancer Center - Carmichael · Carmichael, CA
- Mercy San Juan Medical Center · Carmichael, CA
- Mercy Cancer Center - Elk Grove · Elk Grove, CA
- Kaiser Permanente-Fontana · Fontana, CA
- Palo Alto Medical Foundation-Fremont · Fremont, CA
- Kaiser Permanente South Bay · Harbor City, CA
- Kaiser Permanente-Irvine · Irvine, CA
- Kaiser Permanente Los Angeles Medical Center · Los Angeles, CA
- Kaiser Permanente West Los Angeles · Los Angeles, CA
- Memorial Medical Center · Modesto, CA
- Palo Alto Medical Foundation-Camino Division · Mountain View, CA
- Kaiser Permanente-Ontario · Ontario, CA
- Palo Alto Medical Foundation Health Care · Palo Alto, CA
- Kaiser Permanente - Panorama City · Panorama City, CA
- Kaiser Permanente-Riverside · Riverside, CA
- Mercy Cancer Center - Rocklin · Rocklin, CA
- Sutter Cancer Centers Radiation Oncology Services-Roseville · Roseville, CA
- Sutter Roseville Medical Center · Roseville, CA
- Mercy Cancer Center - Sacramento · Sacramento, CA
- Sutter Medical Center Sacramento · Sacramento, CA
- Kaiser Permanente-San Diego Zion · San Diego, CA
- California Pacific Medical Center-Pacific Campus · San Francisco, CA
- Kaiser Permanente-San Marcos · San Marcos, CA
- Palo Alto Medical Foundation-Santa Cruz · Santa Cruz, CA
- Sutter Pacific Medical Foundation · Santa Rosa, CA
- Palo Alto Medical Foundation-Sunnyvale · Sunnyvale, CA
- Sutter Solano Medical Center/Cancer Center · Vallejo, CA
- Woodland Memorial Hospital · Woodland, CA
- Kaiser Permanente-Woodland Hills · Woodland Hills, CA
Colorado · 3
- AdventHealth Porter · Denver, CO
- AdventHealth Littleton · Littleton, CO
- AdventHealth Parker · Parker, CO
Connecticut · 11
- Smilow Cancer Hospital-Derby Care Center · Derby, CT
- Smilow Cancer Hospital Care Center-Fairfield · Fairfield, CT
- Smilow Cancer Hospital Care Center at Greenwich · Greenwich, CT
- Smilow Cancer Hospital Care Center - Guilford · Guilford, CT
- Yale University · New Haven, CT
- Yale-New Haven Hospital North Haven Medical Center · North Haven, CT
- Smilow Cancer Hospital Care Center at Long Ridge · Stamford, CT
- Smilow Cancer Hospital-Torrington Care Center · Torrington, CT
- Smilow Cancer Hospital Care Center-Trumbull · Trumbull, CT
- Smilow Cancer Hospital-Waterbury Care Center · Waterbury, CT
- Smilow Cancer Hospital Care Center - Waterford · Waterford, CT
Florida · 3
- Holy Cross Hospital · Fort Lauderdale, FL
- Mayo Clinic in Florida · Jacksonville, FL
- Moffitt Cancer Center · Tampa, FL
Hawaii · 8
- Hawaii Cancer Care - Westridge · ‘Aiea, HI
- The Queen's Medical Center - West Oahu · ‘Ewa Beach, HI
- Hawaii Cancer Care Inc - Waterfront Plaza · Honolulu, HI
- Queen's Cancer Cenrer - POB I · Honolulu, HI
- Queen's Cancer Center - Kuakini · Honolulu, HI
- Queen's Medical Center · Honolulu, HI
- Straub Clinic and Hospital · Honolulu, HI
- University of Hawaii Cancer Center · Honolulu, HI
Idaho · 4
- Kootenai Health - Coeur d'Alene · Coeur d'Alene, ID
- Saint Alphonsus Cancer Care Center-Nampa · Nampa, ID
- Kootenai Clinic Cancer Services - Post Falls · Post Falls, ID
- Kootenai Clinic Cancer Services - Sandpoint · Sandpoint, ID
Illinois · 30
- Rush-Copley Medical Center · Aurora, IL
- Centralia Oncology Clinic · Centralia, IL
- Northwestern University · Chicago, IL
- University of Chicago Comprehensive Cancer Center · Chicago, IL
- Carle at The Riverfront · Danville, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Northwestern Medicine Cancer Center Kishwaukee · DeKalb, IL
- Carle Physician Group-Effingham · Effingham, IL
- Crossroads Cancer Center · Effingham, IL
- Northwestern Medicine Cancer Center Delnor · Geneva, IL
- Northwestern Medicine Glenview Outpatient Center · Glenview, IL
- Northwestern Medicine Grayslake Outpatient Center · Grayslake, IL
- Ingalls Memorial Hospital · Harvey, IL
- Northwestern Medicine Lake Forest Hospital · Lake Forest, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- SSM Health Good Samaritan · Mount Vernon, IL
- UC Comprehensive Cancer Center at Silver Cross · New Lenox, IL
- Carle BroMenn Medical Center · Normal, IL
- Carle Cancer Institute Normal · Normal, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- Northwestern Medicine Orland Park · Orland Park, IL
- University of Chicago Medicine-Orland Park · Orland Park, IL
- UW Health Carbone Cancer Center Rockford · Rockford, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Springfield Clinic · Springfield, IL
- Springfield Memorial Hospital · Springfield, IL
- Carle Cancer Center · Urbana, IL
- Northwestern Medicine Cancer Center Warrenville · Warrenville, IL
- Rush-Copley Healthcare Center · Yorkville, IL
Indiana · 1
- UChicago Medicine Northwest Indiana · Crown Point, IN
Iowa · 15
- Mary Greeley Medical Center · Ames, IA
- McFarland Clinic - Ames · Ames, IA
- UI Health Care Mission Cancer and Blood - Ankeny Clinic · Ankeny, IA
- Saint Anthony Regional Hospital · Carroll, IA
- Mercy Cancer Center-West Lakes · Clive, IA
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic · Clive, IA
- Broadlawns Medical Center · Des Moines, IA
- Iowa Methodist Medical Center · Des Moines, IA
- Mercy Medical Center - Des Moines · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Des Moines Clinic · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Laurel Clinic · Des Moines, IA
- McFarland Clinic - Trinity Cancer Center · Fort Dodge, IA
- McFarland Clinic - Marshalltown · Marshalltown, IA
- UI Health Care Mission Cancer and Blood - Waukee Clinic · Waukee, IA
- Mercy Medical Center-West Lakes · West Des Moines, IA
Louisiana · 5
- LSU Health Baton Rouge-North Clinic · Baton Rouge, LA
- Our Lady of the Lake Physician Group · Baton Rouge, LA
- East Jefferson General Hospital · Metairie, LA
- LSU Healthcare Network / Metairie Multi-Specialty Clinic · Metairie, LA
- University Medical Center New Orleans · New Orleans, LA
Massachusetts · 2
- Lahey Clinic · Burlington, MA
- Lahey Clinic Peabody · Peabody, MA
Michigan · 30
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor · Ann Arbor, MI
- University of Michigan Rogel Cancer Center · Ann Arbor, MI
- Bronson Battle Creek · Battle Creek, MI
- Trinity Health IHA Medical Group Hematology Oncology - Brighton · Brighton, MI
- Trinity Health Medical Center - Brighton · Brighton, MI
- Trinity Health IHA Medical Group Hematology Oncology - Canton · Canton, MI
- Trinity Health Medical Center - Canton · Canton, MI
- Chelsea Hospital · Chelsea, MI
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital · Chelsea, MI
- Henry Ford Macomb Hospital-Clinton Township · Clinton Township, MI
- Corewell Health Dearborn Hospital · Dearborn, MI
- Henry Ford Medical Center-Fairlane · Dearborn, MI
- Henry Ford Health Saint John Hospital · Detroit, MI
- Henry Ford Hospital · Detroit, MI
- Cancer Hematology Centers - Flint · Flint, MI
- Genesys Hurley Cancer Institute · Flint, MI
- Hurley Medical Center · Flint, MI
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital · Grand Rapids, MI
- Trinity Health Grand Rapids Hospital · Grand Rapids, MI
- Henry Ford Saint John Hospital - Academic · Grosse Pointe Woods, MI
- Henry Ford Saint John Hospital - Breast · Grosse Pointe Woods, MI
- Henry Ford Saint John Hospital - Van Elslander · Grosse Pointe Woods, MI
- Allegiance Health · Jackson, MI
- Bronson Methodist Hospital · Kalamazoo, MI
- West Michigan Cancer Center · Kalamazoo, MI
- Trinity Health Saint Mary Mercy Livonia Hospital · Livonia, MI
- Henry Ford Saint John Hospital - Macomb Medical · Macomb, MI
- Henry Ford Warren Hospital - Breast Macomb · Macomb, MI
- Trinity Health Muskegon Hospital · Muskegon, MI
- Corewell Health Lakeland Hospitals - Niles Hospital · Niles, MI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.