Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors
NCT05040360
This study is recruiting at 379 US sites in 40 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase II trial studies the effect of capecitabine and temozolomide after surgery in treating patients with high-risk well-differentiated pancreatic neuroendocrine tumors. Chemotherapy drugs, such as capecitabine and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving capecitabine and temozolomide after surgery could prevent or delay the return of cancer in patients with high-risk well-differentiated pancreatic neuroendocrine tumors.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Metastatic Malignant Neoplasm in the Liver
- Pancreatic Neuroendocrine Tumor
- Stage I Pancreatic Neuroendocrine Tumor AJCC v8
- Stage II Pancreatic Neuroendocrine Tumor AJCC v8
- Stage III Pancreatic Neuroendocrine Tumor AJCC v8
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- SWOG Cancer Research Network
- Last updated on ClinicalTrials.gov
- December 15, 2025
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alaska · 6
- Alaska Breast Care and Surgery LLC · Anchorage, AK
- Alaska Oncology and Hematology LLC · Anchorage, AK
- Alaska Women's Cancer Care · Anchorage, AK
- Anchorage Associates in Radiation Medicine · Anchorage, AK
- Katmai Oncology Group · Anchorage, AK
- Providence Alaska Medical Center · Anchorage, AK
Arizona · 6
- Banner MD Anderson Cancer Center · Gilbert, AZ
- Kingman Regional Medical Center · Kingman, AZ
- Cancer Center at Saint Joseph's · Phoenix, AZ
- Mayo Clinic Hospital in Arizona · Phoenix, AZ
- Banner University Medical Center - Tucson · Tucson, AZ
- University of Arizona Cancer Center-North Campus · Tucson, AZ
Arkansas · 2
- Mercy Hospital Fort Smith · Fort Smith, AR
- CARTI Cancer Center · Little Rock, AR
California · 28
- Mission Hope Medical Oncology - Arroyo Grande · Arroyo Grande, CA
- PCR Oncology · Arroyo Grande, CA
- Tower Cancer Research Foundation · Beverly Hills, CA
- Keck Medicine of USC Buena Park · Buena Park, CA
- Providence Saint Joseph Medical Center/Disney Family Cancer Center · Burbank, CA
- Mercy Cancer Center - Carmichael · Carmichael, CA
- Mercy San Juan Medical Center · Carmichael, CA
- Mercy Cancer Center - Elk Grove · Elk Grove, CA
- Keck Medicine of USC Huntington Beach · Huntington Beach, CA
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care · Irvine, CA
- Cedars Sinai Medical Center · Los Angeles, CA
- Keck Medicine of USC Koreatown · Los Angeles, CA
- Los Angeles General Medical Center · Los Angeles, CA
- USC / Norris Comprehensive Cancer Center · Los Angeles, CA
- Mercy Cancer Center · Merced, CA
- Providence Queen of The Valley · Napa, CA
- USC Norris Oncology/Hematology-Newport Beach · Newport Beach, CA
- UC Irvine Health/Chao Family Comprehensive Cancer Center · Orange, CA
- Keck Medical Center of USC Pasadena · Pasadena, CA
- Mercy Cancer Center - Rocklin · Rocklin, CA
- Mercy Cancer Center - Sacramento · Sacramento, CA
- Pacific Central Coast Health Center-San Luis Obispo · San Luis Obispo, CA
- Mission Hope Medical Oncology - Santa Maria · Santa Maria, CA
- Providence Medical Foundation - Santa Rosa · Santa Rosa, CA
- Providence Santa Rosa Memorial Hospital · Santa Rosa, CA
- Saint Joseph's Medical Center · Stockton, CA
- Torrance Memorial Physician Network - Cancer Care · Torrance, CA
- Woodland Memorial Hospital · Woodland, CA
Colorado · 17
- Penrose-Saint Francis Healthcare · Colorado Springs, CO
- Rocky Mountain Cancer Centers-Penrose · Colorado Springs, CO
- Saint Francis Cancer Center · Colorado Springs, CO
- Cancer Center of Colorado at Sloan's Lake · Denver, CO
- National Jewish Health-Main Campus · Denver, CO
- Saint Joseph Hospital - Cancer Centers of Colorado · Denver, CO
- CommonSpirit Cancer Center Mercy · Durango, CO
- Mercy Medical Center · Durango, CO
- National Jewish Health-Western Hematology Oncology · Golden, CO
- Saint Mary's Hospital and Regional Medical Center · Grand Junction, CO
- Good Samaritan Hospital - Cancer Centers of Colorado · Lafayette, CO
- Saint Anthony Hospital · Lakewood, CO
- Longmont United Hospital · Longmont, CO
- Saint Mary Corwin Medical Center · Pueblo, CO
- National Jewish Health-Northern Hematology Oncology · Thornton, CO
- Saint Anthony North Hospital · Westminster, CO
- Intermountain Health Lutheran Hospital · Wheat Ridge, CO
Connecticut · 13
- Smilow Cancer Hospital-Derby Care Center · Derby, CT
- Smilow Cancer Hospital Care Center-Fairfield · Fairfield, CT
- Smilow Cancer Hospital Care Center at Glastonbury · Glastonbury, CT
- Smilow Cancer Hospital Care Center at Greenwich · Greenwich, CT
- Smilow Cancer Hospital Care Center - Guilford · Guilford, CT
- Smilow Cancer Hospital Care Center at Saint Francis · Hartford, CT
- Yale University · New Haven, CT
- Yale-New Haven Hospital North Haven Medical Center · North Haven, CT
- Smilow Cancer Hospital-Orange Care Center · Orange, CT
- Smilow Cancer Hospital-Torrington Care Center · Torrington, CT
- Smilow Cancer Hospital Care Center-Trumbull · Trumbull, CT
- Smilow Cancer Hospital-Waterbury Care Center · Waterbury, CT
- Smilow Cancer Hospital Care Center - Waterford · Waterford, CT
District of Columbia · 1
- George Washington University Medical Center · Washington D.C., DC
Florida · 12
- Schulze Family Foundation Cancer Clinic - Bonita Health Center · Bonita Springs, FL
- UM Sylvester Comprehensive Cancer Center at Coral Gables · Coral Gables, FL
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach · Deerfield Beach, FL
- Regional Cancer Center-Lee Memorial Health System · Fort Myers, FL
- UM Sylvester Comprehensive Cancer Center at Kendall · Miami, FL
- University of Miami Miller School of Medicine-Sylvester Cancer Center · Miami, FL
- University of Miami Sylvester Comprehensive Cancer Center at Sole Mia · North Miami, FL
- UM Sylvester Comprehensive Cancer Center at Plantation · Plantation, FL
- Moffitt Cancer Center · Tampa, FL
- Moffitt Cancer Center - McKinley Campus · Tampa, FL
- Moffitt Cancer Center-International Plaza · Tampa, FL
- Tampa General Hospital · Tampa, FL
Georgia · 4
- Emory Saint Joseph's Hospital · Atlanta, GA
- Emory University Hospital Midtown · Atlanta, GA
- Emory University Hospital/Winship Cancer Institute · Atlanta, GA
- Emory Decatur Hospital · Decatur, GA
Idaho · 8
- Saint Luke's Cancer Institute - Boise · Boise, ID
- Kootenai Health - Coeur d'Alene · Coeur d'Alene, ID
- Saint Luke's Cancer Institute - Fruitland · Fruitland, ID
- Saint Luke's Cancer Institute - Meridian · Meridian, ID
- Saint Luke's Cancer Institute - Nampa · Nampa, ID
- Kootenai Clinic Cancer Services - Post Falls · Post Falls, ID
- Kootenai Clinic Cancer Services - Sandpoint · Sandpoint, ID
- Saint Luke's Cancer Institute - Twin Falls · Twin Falls, ID
Illinois · 24
- OSF Saint Anthony's Health Center · Alton, IL
- Rush-Copley Medical Center · Aurora, IL
- Saint Mary's Hospital · Centralia, IL
- Northwestern University · Chicago, IL
- University of Chicago Comprehensive Cancer Center · Chicago, IL
- University of Illinois · Chicago, IL
- Carle at The Riverfront · Danville, IL
- Northwestern Medicine Cancer Center Kishwaukee · DeKalb, IL
- Carle Physician Group-Effingham · Effingham, IL
- Northwestern Medicine Cancer Center Delnor · Geneva, IL
- Northwestern Medicine Glenview Outpatient Center · Glenview, IL
- Northwestern Medicine Grayslake Outpatient Center · Grayslake, IL
- Northwestern Medicine Lake Forest Hospital · Lake Forest, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- SSM Health Good Samaritan · Mount Vernon, IL
- UC Comprehensive Cancer Center at Silver Cross · New Lenox, IL
- Northwestern Medicine Orland Park · Orland Park, IL
- University of Chicago Medicine-Orland Park · Orland Park, IL
- UW Health Carbone Cancer Center Rockford · Rockford, IL
- Memorial Hospital East · Shiloh, IL
- Carle Cancer Center · Urbana, IL
- The Carle Foundation Hospital · Urbana, IL
- Northwestern Medicine Cancer Center Warrenville · Warrenville, IL
- Rush-Copley Healthcare Center · Yorkville, IL
Iowa · 6
- Mary Greeley Medical Center · Ames, IA
- McFarland Clinic - Ames · Ames, IA
- McFarland Clinic - Boone · Boone, IA
- McFarland Clinic - Trinity Cancer Center · Fort Dodge, IA
- McFarland Clinic - Jefferson · Jefferson, IA
- McFarland Clinic - Marshalltown · Marshalltown, IA
Kansas · 3
- Central Care Cancer Center - Garden City · Garden City, KS
- Central Care Cancer Center - Great Bend · Great Bend, KS
- Mercy Hospital Pittsburg · Pittsburg, KS
Kentucky · 8
- Flaget Memorial Hospital · Bardstown, KY
- Commonwealth Cancer Center-Corbin · Corbin, KY
- Saint Joseph Hospital · Lexington, KY
- Saint Joseph Hospital East · Lexington, KY
- Saint Joseph Radiation Oncology Resource Center · Lexington, KY
- University of Kentucky/Markey Cancer Center · Lexington, KY
- Saint Joseph London · London, KY
- Saint Joseph Mount Sterling · Mount Sterling, KY
Louisiana · 1
- East Jefferson General Hospital · Metairie, LA
Maryland · 2
- Johns Hopkins University/Sidney Kimmel Cancer Center · Baltimore, MD
- Mercy Medical Center · Baltimore, MD
Michigan · 9
- University of Michigan Comprehensive Cancer Center · Ann Arbor, MI
- University of Michigan - Brighton Center for Specialty Care · Brighton, MI
- Henry Ford Hematology Oncology - Hayes · Clinton Township, MI
- Henry Ford Macomb Hospital-Clinton Township · Clinton Township, MI
- Henry Ford Medical Center-Fairlane · Dearborn, MI
- Henry Ford Hospital · Detroit, MI
- Allegiance Health · Jackson, MI
- Henry Ford Medical Center-Columbus · Novi, MI
- Henry Ford West Bloomfield Hospital · West Bloomfield, MI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.