Pre-operative SABR With and Without Caloric Restriction for Early Stage Breast Cancer

Summary

This phase II trial studies the effect of calorie reduction while undergoing stereotactic ablative radiation therapy in treating patients with breast cancer. Stereotactic ablative radiation therapy (sABR) is a highly focused radiation treatment that gives an intense dose of radiation concentrated on a tumor, while limiting the dose to the surrounding organ. Giving SABR before surgery may make the tumor smaller. Adding dietary restrictions in combination with radiation therapy may help increase local control and decrease the spread of the cancer to other places in the body.

Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov

Conditions studied

• Anatomic Stage 0 Breast Cancer AJCC v8
• Anatomic Stage 1 Breast Cancer AJCC v8
• Anatomic Stage 2 Breast Cancer AJCC v8
• Anatomic Stage 3 Breast Cancer AJCC v8
• Breast Ductal Carcinoma in Situ
• Invasive Breast Carcinoma
• Triple Negative Breast Carcinoma

Eligibility basics and study details

Study type

Interventional

Phase

Not applicable

Ages

40 years and older

Sex

All

Healthy volunteers

Not accepted

Sponsor

Thomas Jefferson University

Last updated on ClinicalTrials.gov

January 23, 2026

These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.

US recruiting sites