ATEMPT 2.0: Adjuvant T-DM1 vs TH
NCT04893109
This study is recruiting at 46 US sites in 13 states, according to its ClinicalTrials.gov record last updated .
Summary
This research study is studying how well newly diagnosed breast cancer that has tested positive for a protein called HER2 responds using one of two different combination of HER2-directed therapies as a treatment after surgery. The name of the study drugs involved are: Trastuzumab-emtansine (T-DM1, Kadcyla) Trastuzumab SC (Herceptin Hylecta) Paclitaxel
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Breast Cancer
- HER2-positive Breast Cancer
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Dana-Farber Cancer Institute
- Last updated on ClinicalTrials.gov
- August 19, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
California · 1
- UCSF Helen Diller Family Comprehensive Cancer Center · San Francisco, CA
Connecticut · 14
- Smilow Cancer Hospital Care center at Derby · Derby, CT
- Smilow Cancer Hospital Care center at Fairfield · Fairfield, CT
- Smilow Cancer Hospital Care center at Glastonbury · Glastonbury, CT
- Smilow Cancer Hospital Care center at Greenwich · Greenwich, CT
- Smilow Cancer Hospital Care center at Guilford · Guilford, CT
- Smilow Cancer Hospital Care center at St. Francis · Hartford, CT
- Smilow Cancer Hospital Care center at Long Ridge · Long Ridge, CT
- Yale Cancer Center at Yale University School of Medicine · New Haven, CT
- Smilow Cancer Hospital Care center at North Haven · North Haven, CT
- Stamford Hospital · Stamford, CT
- Smilow Cancer Hospital Care center at Torrington · Torrington, CT
- Smilow Cancer Hospital Care center at Trumbull · Trumbull, CT
- Smilow Cancer Hospital Care center at Waterbury · Waterbury, CT
- Smilow Cancer Hospital Care center at Waterford · Waterford, CT
Florida · 2
- Miami Cancer Institute/Baptist Hospital of Miami · Miami, FL
- Miami Cancer Institute - Plantation (MCIP) · Plantation, FL
Illinois · 1
- The University of Chicago Medical Center · Chicago, IL
Maine · 2
- Eastern Maine Medical Center (Northern Light) · Brewer, ME
- New England Cancer Specialists · Scarborough, ME
Massachusetts · 11
- Dana Farber Cancer Institute · Boston, MA
- Massachusetts General Hospital · Boston, MA
- Dana-Farber at St. Elizabeth's Medical Center · Brighton, MA
- Lahey Clinic · Burlington, MA
- Mass General North Shore Cancer Center · Danvers, MA
- Dana-Farber Brigham Cancer Center - Foxborough · Foxborough, MA
- Dana-Farber Cancer Instiute - Merrimack Valley · Methuen, MA
- Dana-Farber at Milford · Milford, MA
- Newton Wellesley Hospital · Newton, MA
- Berkshire Medical Center · Pittsfield, MA
- Dana Farber at South Shore Hospital · Weymouth, MA
New Hampshire · 4
- NH Oncology-Hematology, PA - Payson Center for Cancer Care · Concord, NH
- Dana-Farber Cancer Insitute at Londonderry Hospital · Londonderry, NH
- Solinsky Center for Cancer Care (NH Oncology-Hematology, PA) · Manchester, NH
- New England Cancer Specialists - Portsmouth · Portsmouth, NH
New York · 4
- New York University Langone Hospital -Brooklyn · Brooklyn, NY
- New York University Langone Hospital - Long Island · Mineola, NY
- New York University Langone Health · New York, NY
- Northwell University · New York, NY
Ohio · 1
- Stefanie Spielman Comprehensive Breast Center · Columbus, OH
Pennsylvania · 2
- University of Pennsylvania, Abramson Cancer Center · Philadelphia, PA
- University of Pittsburgh Medical Center Cancer UPMC- Magee Women's Hospital · Pittsburgh, PA
Rhode Island · 1
- Smilow Cancer Hospital Care center at Westerly · Westerly, RI
Tennessee · 2
- Greco-Hainsworth Centers for Research/Tennessee Oncology · Nashville, TN
- SCRI Oncology Partners · Nashville, TN
Texas · 1
- MD Anderson Cancer Center · Houston, TX
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.