APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation
NCT04858334
This study is recruiting at 258 US sites in 35 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase II trial investigates how well the addition of olaparib following completion of surgery and chemotherapy works in treating patients with pancreatic cancer that has been surgically removed (resected) and has a pathogenic mutation in BRCA1, BRCA2, or PALB2. Olaparib is an inhibitor of PARP, an enzyme that helps repair deoxyribonucleic acid (DNA) when it becomes damaged. Blocking PARP may help keep tumor cells from repairing their damaged DNA, causing them to die. PARP inhibitors are a type of targeted therapy.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Pancreatic Acinar Cell Carcinoma
- Pancreatic Adenosquamous Carcinoma
- Pancreatic Squamous Cell Carcinoma
- Resectable Pancreatic Acinar Cell Carcinoma
- Resectable Pancreatic Adenocarcinoma
- Resectable Pancreatic Adenosquamous Carcinoma
- Resectable Pancreatic Carcinoma
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- National Cancer Institute (NCI)
- Last updated on ClinicalTrials.gov
- October 15, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 1
- Kingman Regional Medical Center · Kingman, AZ
California · 13
- Alta Bates Summit Medical Center-Herrick Campus · Berkeley, CA
- Palo Alto Medical Foundation-Fremont · Fremont, CA
- Memorial Medical Center · Modesto, CA
- Saint Joseph Hospital - Orange · Orange, CA
- Sutter Roseville Medical Center · Roseville, CA
- Sutter Medical Center Sacramento · Sacramento, CA
- California Pacific Medical Center-Pacific Campus · San Francisco, CA
- Mills Health Center · San Mateo, CA
- Palo Alto Medical Foundation-Santa Cruz · Santa Cruz, CA
- Providence Medical Foundation - Santa Rosa · Santa Rosa, CA
- Sutter Pacific Medical Foundation · Santa Rosa, CA
- Palo Alto Medical Foundation-Sunnyvale · Sunnyvale, CA
- Northbay Cancer Center · Vacaville, CA
District of Columbia · 1
- Sibley Memorial Hospital · Washington D.C., DC
Florida · 7
- AdventHealth Altamonte · Altamonte Springs, FL
- UM Sylvester Comprehensive Cancer Center at Coral Gables · Coral Gables, FL
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach · Deerfield Beach, FL
- UM Sylvester Comprehensive Cancer Center at Kendall · Miami, FL
- University of Miami Miller School of Medicine-Sylvester Cancer Center · Miami, FL
- AdventHealth Orlando · Orlando, FL
- UM Sylvester Comprehensive Cancer Center at Plantation · Plantation, FL
Hawaii · 8
- Hawaii Cancer Care - Westridge · ‘Aiea, HI
- Pali Momi Medical Center · ‘Aiea, HI
- The Queen's Medical Center - West Oahu · ‘Ewa Beach, HI
- Hawaii Cancer Care Inc - Waterfront Plaza · Honolulu, HI
- Queen's Cancer Cenrer - POB I · Honolulu, HI
- Queen's Cancer Center - Kuakini · Honolulu, HI
- Queen's Medical Center · Honolulu, HI
- Straub Clinic and Hospital · Honolulu, HI
Idaho · 9
- Saint Luke's Cancer Institute - Boise · Boise, ID
- Kootenai Health - Coeur d'Alene · Coeur d'Alene, ID
- Saint Luke's Cancer Institute - Fruitland · Fruitland, ID
- Saint Luke's Cancer Institute - Meridian · Meridian, ID
- Saint Alphonsus Cancer Care Center-Nampa · Nampa, ID
- Saint Luke's Cancer Institute - Nampa · Nampa, ID
- Kootenai Clinic Cancer Services - Post Falls · Post Falls, ID
- Kootenai Clinic Cancer Services - Sandpoint · Sandpoint, ID
- Saint Luke's Cancer Institute - Twin Falls · Twin Falls, ID
Illinois · 33
- Illinois CancerCare-Bloomington · Bloomington, IL
- Illinois CancerCare-Canton · Canton, IL
- Illinois CancerCare-Carthage · Carthage, IL
- Centralia Oncology Clinic · Centralia, IL
- University of Chicago Comprehensive Cancer Center · Chicago, IL
- University of Illinois · Chicago, IL
- Carle at The Riverfront · Danville, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Illinois CancerCare-Dixon · Dixon, IL
- Carle Physician Group-Effingham · Effingham, IL
- Crossroads Cancer Center · Effingham, IL
- Elmhurst Memorial Hospital · Elmhurst, IL
- Illinois CancerCare-Eureka · Eureka, IL
- Illinois CancerCare-Galesburg · Galesburg, IL
- Illinois CancerCare-Kewanee Clinic · Kewanee, IL
- Illinois CancerCare-Macomb · Macomb, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- Edward Hospital/Cancer Center · Naperville, IL
- UC Comprehensive Cancer Center at Silver Cross · New Lenox, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- University of Chicago Medicine-Orland Park · Orland Park, IL
- Illinois CancerCare-Ottawa Clinic · Ottawa, IL
- Illinois CancerCare-Pekin · Pekin, IL
- Illinois CancerCare-Peoria · Peoria, IL
- Illinois CancerCare-Peru · Peru, IL
- Edward Hospital/Cancer Center?Plainfield · Plainfield, IL
- Illinois CancerCare-Princeton · Princeton, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Springfield Clinic · Springfield, IL
- Springfield Memorial Hospital · Springfield, IL
- Carle Cancer Center · Urbana, IL
- Illinois CancerCare - Washington · Washington, IL
Indiana · 4
- Northwest Cancer Center - Crown Point · Crown Point, IN
- Northwest Oncology LLC · Dyer, IN
- Saint Mary Medical Center · Hobart, IN
- The Community Hospital · Munster, IN
Iowa · 16
- Mary Greeley Medical Center · Ames, IA
- McFarland Clinic - Ames · Ames, IA
- UI Health Care Mission Cancer and Blood - Ankeny Clinic · Ankeny, IA
- Saint Anthony Regional Hospital · Carroll, IA
- Mercy Cancer Center-West Lakes · Clive, IA
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic · Clive, IA
- Broadlawns Medical Center · Des Moines, IA
- Iowa Methodist Medical Center · Des Moines, IA
- Mercy Medical Center - Des Moines · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Des Moines Clinic · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Laurel Clinic · Des Moines, IA
- McFarland Clinic - Trinity Cancer Center · Fort Dodge, IA
- UI Healthcare Mission Cancer and Blood - Fort Dodge · Fort Dodge, IA
- McFarland Clinic - Marshalltown · Marshalltown, IA
- UI Health Care Mission Cancer and Blood - Waukee Clinic · Waukee, IA
- Mercy Medical Center-West Lakes · West Des Moines, IA
Kansas · 10
- HaysMed · Hays, KS
- University of Kansas Cancer Center · Kansas City, KS
- Lawrence Memorial Hospital · Lawrence, KS
- The University of Kansas Cancer Center - Olathe · Olathe, KS
- University of Kansas Cancer Center-Overland Park · Overland Park, KS
- University of Kansas Hospital-Indian Creek Campus · Overland Park, KS
- Freeman Physician Group of Pittsburg · Pittsburg, KS
- Salina Regional Health Center · Salina, KS
- University of Kansas Health System Saint Francis Campus · Topeka, KS
- University of Kansas Hospital-Westwood Cancer Center · Westwood, KS
Louisiana · 2
- Louisiana Hematology Oncology Associates LLC · Baton Rouge, LA
- Mary Bird Perkins Cancer Center · Baton Rouge, LA
Michigan · 30
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor · Ann Arbor, MI
- University of Michigan Rogel Cancer Center · Ann Arbor, MI
- Trinity Health IHA Medical Group Hematology Oncology - Brighton · Brighton, MI
- Trinity Health Medical Center - Brighton · Brighton, MI
- Trinity Health IHA Medical Group Hematology Oncology - Canton · Canton, MI
- Trinity Health Medical Center - Canton · Canton, MI
- Chelsea Hospital · Chelsea, MI
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital · Chelsea, MI
- Hematology Oncology Consultants-Clarkston · Clarkston, MI
- Corewell Health Dearborn Hospital · Dearborn, MI
- Henry Ford Health Saint John Hospital · Detroit, MI
- Cancer Hematology Centers - Flint · Flint, MI
- Genesys Hurley Cancer Institute · Flint, MI
- Henry Ford Saint John Hospital - Academic · Grosse Pointe Woods, MI
- Henry Ford Saint John Hospital - Van Elslander · Grosse Pointe Woods, MI
- Trinity Health Saint Mary Mercy Livonia Hospital · Livonia, MI
- Henry Ford Saint John Hospital - Macomb Medical · Macomb, MI
- Henry Ford Health Providence Novi Hospital · Novi, MI
- Michigan Healthcare Professionals Pontiac · Pontiac, MI
- Newland Medical Associates-Pontiac · Pontiac, MI
- Trinity Health Saint Joseph Mercy Oakland Hospital · Pontiac, MI
- Corewell Health William Beaumont University Hospital · Royal Oak, MI
- MyMichigan Medical Center Saginaw · Saginaw, MI
- Henry Ford Health Providence Southfield Hospital · Southfield, MI
- MyMichigan Medical Center Tawas · Tawas City, MI
- Corewell Health Beaumont Troy Hospital · Troy, MI
- Henry Ford Health Warren Hospital · Warren, MI
- Henry Ford Warren Hospital - GLCMS · Warren, MI
- Huron Gastroenterology PC · Ypsilanti, MI
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus · Ypsilanti, MI
Minnesota · 7
- Sanford Joe Lueken Cancer Center · Bemidji, MN
- Mercy Hospital · Coon Rapids, MN
- Saint Luke's Hospital of Duluth · Duluth, MN
- Abbott-Northwestern Hospital · Minneapolis, MN
- Park Nicollet Clinic - Saint Louis Park · Saint Louis Park, MN
- Regions Hospital · Saint Paul, MN
- United Hospital · Saint Paul, MN
Mississippi · 5
- Baptist Memorial Hospital and Cancer Center-Golden Triangle · Columbus, MS
- Baptist Cancer Center-Grenada · Grenada, MS
- Baptist Memorial Hospital and Cancer Center-Union County · New Albany, MS
- Baptist Memorial Hospital and Cancer Center-Oxford · Oxford, MS
- Baptist Memorial Hospital and Cancer Center-Desoto · Southhaven, MS
Missouri · 4
- Mercy Oncology and Hematology - Clayton-Clarkson · Ballwin, MO
- Saint Francis Medical Center · Cape Girardeau, MO
- Parkland Health Center - Farmington · Farmington, MO
- Saint Luke's Hospital of Kansas City · Kansas City, MO
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.