Testing the Combination of Venetoclax and Rituximab, in Comparison to the Usual Treatment (Ibrutinib Plus Rituximab or Zanubrutinib Alone) for Waldenstrom's Macroglobulinemia/Lymphoplasmacytic Lymphoma
NCT04840602
This study is recruiting at 101 US sites in 19 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase II trial studies the effects of venetoclax and rituximab in comparison to ibrutinib and rituximab or zanubrutinib in treating patients with previously untreated Waldenstrom's macroglobulinemia/lymphoplasmacytic lymphoma. Ibrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Rituximab is a monoclonal antibody. It binds to a protein called CD20, which is found on B cells (a type of white blood cell) and some types of cancer cells. This may help the immune system kill cancer cells.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Lymphoplasmacytic Lymphoma
- Waldenstrom Macroglobulinemia
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- National Cancer Institute (NCI)
- Last updated on ClinicalTrials.gov
- October 14, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 2
- Banner University Medical Center - Tucson · Tucson, AZ
- University of Arizona Cancer Center-North Campus · Tucson, AZ
California · 1
- City of Hope at Irvine Lennar · Irvine, CA
Florida · 10
- UM Sylvester Comprehensive Cancer Center at Coral Gables · Coral Gables, FL
- UM Sylvester Comprehensive Cancer Center at Coral Springs · Coral Springs, FL
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach · Deerfield Beach, FL
- UM Sylvester Comprehensive Cancer Center at Doral · Doral, FL
- UM Sylvester Comprehensive Cancer Center at Hollywood · Hollywood, FL
- Mayo Clinic in Florida · Jacksonville, FL
- UM Sylvester Comprehensive Cancer Center at Kendall · Miami, FL
- University of Miami Miller School of Medicine-Sylvester Cancer Center · Miami, FL
- University of Miami Sylvester Comprehensive Cancer Center at Sole Mia · North Miami, FL
- UM Sylvester Comprehensive Cancer Center at Plantation · Plantation, FL
Idaho · 4
- Saint Alphonsus Cancer Care Center-Boise · Boise, ID
- Saint Alphonsus Cancer Care Center-Caldwell · Caldwell, ID
- Idaho Urologic Institute-Meridian · Meridian, ID
- Saint Alphonsus Cancer Care Center-Nampa · Nampa, ID
Illinois · 12
- Centralia Oncology Clinic · Centralia, IL
- Carle at The Riverfront · Danville, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Carle Physician Group-Effingham · Effingham, IL
- Crossroads Cancer Center · Effingham, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- Loyola University Medical Center · Maywood, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Springfield Clinic · Springfield, IL
- Springfield Memorial Hospital · Springfield, IL
- Carle Cancer Center · Urbana, IL
Iowa · 4
- Mary Greeley Medical Center · Ames, IA
- McFarland Clinic - Ames · Ames, IA
- McFarland Clinic - Trinity Cancer Center · Fort Dodge, IA
- McFarland Clinic - Marshalltown · Marshalltown, IA
Massachusetts · 1
- Lahey Clinic · Burlington, MA
Michigan · 26
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor · Ann Arbor, MI
- Trinity Health IHA Medical Group Hematology Oncology - Brighton · Brighton, MI
- Trinity Health Medical Center - Brighton · Brighton, MI
- Trinity Health IHA Medical Group Hematology Oncology - Canton · Canton, MI
- Trinity Health Medical Center - Canton · Canton, MI
- Chelsea Hospital · Chelsea, MI
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital · Chelsea, MI
- Hematology Oncology Consultants-Clarkston · Clarkston, MI
- Henry Ford Macomb Hospital-Clinton Township · Clinton Township, MI
- Henry Ford Hospital · Detroit, MI
- Wayne State University/Karmanos Cancer Institute · Detroit, MI
- Weisberg Cancer Treatment Center · Farmington Hills, MI
- Cancer Hematology Centers - Flint · Flint, MI
- Genesys Hurley Cancer Institute · Flint, MI
- Hurley Medical Center · Flint, MI
- University of Michigan Health - Sparrow Lansing · Lansing, MI
- Trinity Health Saint Mary Mercy Livonia Hospital · Livonia, MI
- Henry Ford Medical Center-Columbus · Novi, MI
- Michigan Healthcare Professionals Pontiac · Pontiac, MI
- Newland Medical Associates-Pontiac · Pontiac, MI
- Trinity Health Saint Joseph Mercy Oakland Hospital · Pontiac, MI
- MyMichigan Medical Center Saginaw · Saginaw, MI
- MyMichigan Medical Center Tawas · Tawas City, MI
- Henry Ford West Bloomfield Hospital · West Bloomfield, MI
- Huron Gastroenterology PC · Ypsilanti, MI
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus · Ypsilanti, MI
Minnesota · 7
- Mercy Hospital · Coon Rapids, MN
- Abbott-Northwestern Hospital · Minneapolis, MN
- Hennepin County Medical Center · Minneapolis, MN
- Mayo Clinic in Rochester · Rochester, MN
- Park Nicollet Clinic - Saint Louis Park · Saint Louis Park, MN
- Regions Hospital · Saint Paul, MN
- United Hospital · Saint Paul, MN
Missouri · 3
- Saint Francis Medical Center · Cape Girardeau, MO
- Heartland Regional Medical Center · Saint Joseph, MO
- Mercy Hospital South · St Louis, MO
Montana · 1
- Saint Vincent Frontier Cancer Center · Billings, MT
New Jersey · 3
- Memorial Sloan Kettering Basking Ridge · Basking Ridge, NJ
- Memorial Sloan Kettering Monmouth · Middletown, NJ
- Memorial Sloan Kettering Bergen · Montvale, NJ
New York · 6
- Memorial Sloan Kettering Commack · Commack, NY
- Memorial Sloan Kettering Westchester · Harrison, NY
- Memorial Sloan Kettering Cancer Center · New York, NY
- University of Rochester · Rochester, NY
- Memorial Sloan Kettering Nassau · Uniondale, NY
- Wilmot Cancer Institute at Webster · Webster, NY
North Carolina · 6
- Carolinas Medical Center/Levine Cancer Institute · Charlotte, NC
- Southeastern Medical Oncology Center-Clinton · Clinton, NC
- Levine Cancer Institute-Gaston · Gastonia, NC
- Southeastern Medical Oncology Center-Goldsboro · Goldsboro, NC
- Southeastern Medical Oncology Center-Jacksonville · Jacksonville, NC
- Atrium Health Union/LCI-Union · Monroe, NC
Ohio · 1
- Licking Memorial Hospital · Newark, OH
Oregon · 6
- Saint Alphonsus Cancer Care Center-Baker City · Baker City, OR
- Providence Newberg Medical Center · Newberg, OR
- Saint Alphonsus Cancer Care Center-Ontario · Ontario, OR
- Providence Willamette Falls Medical Center · Oregon City, OR
- Providence Portland Medical Center · Portland, OR
- Providence Saint Vincent Medical Center · Portland, OR
Virginia · 1
- VCU Massey Comprehensive Cancer Center · Richmond, VA
Washington · 3
- Swedish Cancer Institute-Edmonds · Edmonds, WA
- Swedish Cancer Institute-Issaquah · Issaquah, WA
- Swedish Medical Center-First Hill · Seattle, WA
Wisconsin · 4
- ThedaCare Regional Cancer Center · Appleton, WI
- Gundersen Lutheran Medical Center · La Crosse, WI
- Marshfield Medical Center-River Region at Stevens Point · Stevens Point, WI
- Marshfield Medical Center - Weston · Weston, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.