Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial
NCT04566328
This study is recruiting at 301 US sites in 33 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase III trial compares the combination of four drugs (daratumumab, bortezomib, lenalidomide and dexamethasone) to the use of a three drug combination (daratumumab, lenalidomide and dexamethasone). Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Chemotherapy drugs, such as lenalidomide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Plasma Cell Myeloma
- RISS Stage I Plasma Cell Myeloma
- RISS Stage II Plasma Cell Myeloma
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- ECOG-ACRIN Cancer Research Group
- Last updated on ClinicalTrials.gov
- August 19, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 1
- Cancer Center at Saint Joseph's · Phoenix, AZ
Arkansas · 2
- Mercy Hospital Fort Smith · Fort Smith, AR
- CARTI Cancer Center · Little Rock, AR
California · 12
- Mission Hope Medical Oncology - Arroyo Grande · Arroyo Grande, CA
- Mercy Cancer Center - Carmichael · Carmichael, CA
- Mercy San Juan Medical Center · Carmichael, CA
- Mercy Cancer Center - Elk Grove · Elk Grove, CA
- Washington Health · Fremont, CA
- Mercy Cancer Center · Merced, CA
- Mercy Cancer Center - Rocklin · Rocklin, CA
- Mercy Cancer Center - Sacramento · Sacramento, CA
- Pacific Central Coast Health Center-San Luis Obispo · San Luis Obispo, CA
- Mission Hope Medical Oncology - Santa Maria · Santa Maria, CA
- Saint Joseph's Medical Center · Stockton, CA
- Woodland Memorial Hospital · Woodland, CA
Colorado · 6
- Penrose-Saint Francis Healthcare · Colorado Springs, CO
- Rocky Mountain Cancer Centers-Penrose · Colorado Springs, CO
- Saint Francis Cancer Center · Colorado Springs, CO
- CommonSpirit Saint Anthony Hospital Cancer Center · Lakewood, CO
- Saint Mary Corwin Medical Center · Pueblo, CO
- Saint Anthony North Hospital · Westminster, CO
Connecticut · 14
- Smilow Cancer Hospital-Derby Care Center · Derby, CT
- Smilow Cancer Hospital Care Center-Fairfield · Fairfield, CT
- Smilow Cancer Hospital Care Center at Glastonbury · Glastonbury, CT
- Smilow Cancer Hospital Care Center at Greenwich · Greenwich, CT
- Smilow Cancer Hospital Care Center - Guilford · Guilford, CT
- Smilow Cancer Hospital Care Center at Saint Francis · Hartford, CT
- Smilow Cancer Center/Yale-New Haven Hospital · New Haven, CT
- Yale University · New Haven, CT
- Yale-New Haven Hospital North Haven Medical Center · North Haven, CT
- Smilow Cancer Hospital-Orange Care Center · Orange, CT
- Smilow Cancer Hospital-Torrington Care Center · Torrington, CT
- Smilow Cancer Hospital Care Center-Trumbull · Trumbull, CT
- Smilow Cancer Hospital-Waterbury Care Center · Waterbury, CT
- Smilow Cancer Hospital Care Center - Waterford · Waterford, CT
District of Columbia · 1
- Sibley Memorial Hospital · Washington D.C., DC
Florida · 1
- Holy Cross Hospital · Fort Lauderdale, FL
Idaho · 3
- Saint Alphonsus Cancer Care Center-Boise · Boise, ID
- Saint Alphonsus Cancer Care Center-Caldwell · Caldwell, ID
- Saint Alphonsus Cancer Care Center-Nampa · Nampa, ID
Illinois · 43
- OSF Saint Anthony's Health Center · Alton, IL
- Advocate Outpatient Center - Aurora · Aurora, IL
- Advocate Good Shepherd Hospital · Barrington, IL
- Illinois CancerCare-Bloomington · Bloomington, IL
- Illinois CancerCare-Canton · Canton, IL
- Memorial Hospital of Carbondale · Carbondale, IL
- SIH Cancer Institute · Carterville, IL
- Illinois CancerCare-Carthage · Carthage, IL
- Centralia Oncology Clinic · Centralia, IL
- Advocate Illinois Masonic Medical Center · Chicago, IL
- AMG Crystal Lake - Oncology · Crystal Lake, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Northwestern Medicine Cancer Center Kishwaukee · DeKalb, IL
- Illinois CancerCare-Dixon · Dixon, IL
- Advocate Good Samaritan Hospital · Downers Grove, IL
- Crossroads Cancer Center · Effingham, IL
- Advocate Sherman Hospital · Elgin, IL
- Illinois CancerCare-Eureka · Eureka, IL
- Illinois CancerCare-Galesburg · Galesburg, IL
- Northwestern Medicine Cancer Center Delnor · Geneva, IL
- Advocate South Suburban Hospital · Hazel Crest, IL
- Illinois CancerCare-Kewanee Clinic · Kewanee, IL
- AMG Libertyville - Oncology · Libertyville, IL
- Condell Memorial Hospital · Libertyville, IL
- Illinois CancerCare-Macomb · Macomb, IL
- SSM Health Good Samaritan · Mount Vernon, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- HSHS Saint Elizabeth's Hospital · O'Fallon, IL
- Advocate Christ Medical Center · Oak Lawn, IL
- Illinois CancerCare-Ottawa Clinic · Ottawa, IL
- Advocate Lutheran General Hospital · Park Ridge, IL
- Illinois CancerCare-Pekin · Pekin, IL
- Illinois CancerCare-Peoria · Peoria, IL
- Methodist Medical Center of Illinois · Peoria, IL
- Illinois CancerCare-Peru · Peru, IL
- Valley Radiation Oncology · Peru, IL
- Illinois CancerCare-Princeton · Princeton, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Springfield Clinic · Springfield, IL
- Springfield Memorial Hospital · Springfield, IL
- Northwestern Medicine Cancer Center Warrenville · Warrenville, IL
- Illinois CancerCare - Washington · Washington, IL
Indiana · 1
- Indiana University/Melvin and Bren Simon Cancer Center · Indianapolis, IN
Iowa · 21
- Mary Greeley Medical Center · Ames, IA
- McFarland Clinic - Ames · Ames, IA
- UI Health Care Mission Cancer and Blood - Ankeny Clinic · Ankeny, IA
- Saint Anthony Regional Hospital · Carroll, IA
- Mercy Hospital · Cedar Rapids, IA
- Oncology Associates at Mercy Medical Center · Cedar Rapids, IA
- Mercy Cancer Center-West Lakes · Clive, IA
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic · Clive, IA
- Greater Regional Medical Center · Creston, IA
- Broadlawns Medical Center · Des Moines, IA
- Iowa Lutheran Hospital · Des Moines, IA
- Iowa Methodist Medical Center · Des Moines, IA
- Mercy Medical Center - Des Moines · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Des Moines Clinic · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Laurel Clinic · Des Moines, IA
- McFarland Clinic - Trinity Cancer Center · Fort Dodge, IA
- UI Healthcare Mission Cancer and Blood - Fort Dodge · Fort Dodge, IA
- McFarland Clinic - Marshalltown · Marshalltown, IA
- UI Health Care Mission Cancer and Blood - Waukee Clinic · Waukee, IA
- Mercy Medical Center-West Lakes · West Des Moines, IA
- Methodist West Hospital · West Des Moines, IA
Kansas · 3
- Central Care Cancer Center - Garden City · Garden City, KS
- Central Care Cancer Center - Great Bend · Great Bend, KS
- Mercy Hospital Pittsburg · Pittsburg, KS
Kentucky · 6
- CommonSpirit Saint Joseph Hospital - Bardstown · Bardstown, KY
- Commonwealth Cancer Center-Corbin · Corbin, KY
- CommonSpirit Saint Joseph Medical Center - East Lexington · Lexington, KY
- Saint Joseph Radiation Oncology Resource Center · Lexington, KY
- CommonSpirit Saint Joseph Hospital London · London, KY
- CommonSpirit Saint Joseph Hospital Mount Sterling · Mount Sterling, KY
Massachusetts · 2
- Tufts Medical Center · Boston, MA
- Tufts Medical Center Cancer Center Stoneham · Stoneham, MA
Michigan · 34
- MyMichigan Medical Center Gratiot · Alma, MI
- MyMichigan Medical Center Alpena · Alpena, MI
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor · Ann Arbor, MI
- Trinity Health IHA Medical Group Hematology Oncology - Brighton · Brighton, MI
- Trinity Health Medical Center - Brighton · Brighton, MI
- Trinity Health IHA Medical Group Hematology Oncology - Canton · Canton, MI
- Trinity Health Medical Center - Canton · Canton, MI
- Chelsea Hospital · Chelsea, MI
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital · Chelsea, MI
- Hematology Oncology Consultants-Clarkston · Clarkston, MI
- Henry Ford Health Saint John Hospital · Detroit, MI
- OSF Saint Francis Hospital and Medical Group · Escanaba, MI
- Cancer Hematology Centers - Flint · Flint, MI
- Genesee Hematology Oncology PC · Flint, MI
- Genesys Hurley Cancer Institute · Flint, MI
- Hurley Medical Center · Flint, MI
- MyMichigan Medical Center Gladwin · Gladwin, MI
- Henry Ford Saint John Hospital - Academic · Grosse Pointe Woods, MI
- Henry Ford Saint John Hospital - Breast · Grosse Pointe Woods, MI
- Henry Ford Saint John Hospital - Van Elslander · Grosse Pointe Woods, MI
- University of Michigan Health - Sparrow Lansing · Lansing, MI
- Trinity Health Saint Mary Mercy Livonia Hospital · Livonia, MI
- Henry Ford Saint John Hospital - Macomb Medical · Macomb, MI
- Henry Ford Warren Hospital - Breast Macomb · Macomb, MI
- MyMichigan Medical Center Midland · Midland, MI
- MyMichigan Medical Center Mount Pleasant · Mount Pleasant, MI
- Henry Ford Health Providence Novi Hospital · Novi, MI
- Michigan Healthcare Professionals Pontiac · Pontiac, MI
- Newland Medical Associates-Pontiac · Pontiac, MI
- Trinity Health Saint Joseph Mercy Oakland Hospital · Pontiac, MI
- MyMichigan Medical Center Saginaw · Saginaw, MI
- Henry Ford Health Providence Southfield Hospital · Southfield, MI
- MyMichigan Medical Center Tawas · Tawas City, MI
- Henry Ford Health Warren Hospital · Warren, MI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.