Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial
NCT04510597
This study is recruiting at 338 US sites in 32 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase III trial compares the effect of adding surgery to a standard of care immunotherapy-based drug combination versus a standard of care immunotherapy-based drug combination alone in treating patients with kidney cancer that has spread to other places in the body (metastatic). Immunotherapy with monoclonal antibodies, such as nivolumab, ipilimumab, pembrolizumab, and avelumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Metastatic Clear Cell Renal Cell Carcinoma
- Metastatic Renal Cell Carcinoma
- Stage IV Renal Cell Cancer AJCC v8
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- SWOG Cancer Research Network
- Last updated on ClinicalTrials.gov
- October 8, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- University of Alabama at Birmingham Cancer Center · Birmingham, AL
Arizona · 4
- Banner MD Anderson Cancer Center · Gilbert, AZ
- Kingman Regional Medical Center · Kingman, AZ
- Banner University Medical Center - Tucson · Tucson, AZ
- University of Arizona Cancer Center-North Campus · Tucson, AZ
Arkansas · 1
- Mercy Hospital Fort Smith · Fort Smith, AR
California · 37
- PCR Oncology · Arroyo Grande, CA
- Sutter Auburn Faith Hospital · Auburn, CA
- Sutter Cancer Centers Radiation Oncology Services-Auburn · Auburn, CA
- Alta Bates Summit Medical Center-Herrick Campus · Berkeley, CA
- Keck Medicine of USC Buena Park · Buena Park, CA
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park · Cameron Park, CA
- Eden Hospital Medical Center · Castro Valley, CA
- Sutter Davis Hospital · Davis, CA
- City of Hope Comprehensive Cancer Center · Duarte, CA
- Palo Alto Medical Foundation-Fremont · Fremont, CA
- Keck Medicine of USC Huntington Beach · Huntington Beach, CA
- Cedars Sinai Medical Center · Los Angeles, CA
- Keck Medicine of USC Koreatown · Los Angeles, CA
- Los Angeles County-USC Medical Center · Los Angeles, CA
- UCLA / Jonsson Comprehensive Cancer Center · Los Angeles, CA
- USC / Norris Comprehensive Cancer Center · Los Angeles, CA
- Memorial Medical Center · Modesto, CA
- Palo Alto Medical Foundation-Camino Division · Mountain View, CA
- Palo Alto Medical Foundation-Gynecologic Oncology · Mountain View, CA
- USC Norris Oncology/Hematology-Newport Beach · Newport Beach, CA
- Sutter Cancer Research Consortium · Novato, CA
- Palo Alto Medical Foundation Health Care · Palo Alto, CA
- Keck Medical Center of USC Pasadena · Pasadena, CA
- Sutter Cancer Centers Radiation Oncology Services-Roseville · Roseville, CA
- Sutter Roseville Medical Center · Roseville, CA
- Sutter Medical Center Sacramento · Sacramento, CA
- University of California Davis Comprehensive Cancer Center · Sacramento, CA
- California Pacific Medical Center-Pacific Campus · San Francisco, CA
- Mills Health Center · San Mateo, CA
- Palo Alto Medical Foundation-Santa Cruz · Santa Cruz, CA
- Sutter Pacific Medical Foundation · Santa Rosa, CA
- City of Hope South Pasadena · South Pasadena, CA
- Palo Alto Medical Foundation-Sunnyvale · Sunnyvale, CA
- Cedars-Sinai Cancer - Tarzana · Tarzana, CA
- City of Hope Upland · Upland, CA
- Sutter Cancer Centers Radiation Oncology Services-Vacaville · Vacaville, CA
- Sutter Solano Medical Center/Cancer Center · Vallejo, CA
District of Columbia · 1
- MedStar Washington Hospital Center · Washington D.C., DC
Florida · 8
- AdventHealth Altamonte · Altamonte Springs, FL
- AdventHealth Celebration · Celebration, FL
- AdventHealth Kissimmee · Kissimmee, FL
- AdventHealth East Orlando · Orlando, FL
- AdventHealth Medical Group Urology at Orlando · Orlando, FL
- AdventHealth Orlando · Orlando, FL
- Orlando Health Cancer Institute · Orlando, FL
- AdventHealth Winter Park · Winter Park, FL
Illinois · 61
- Saint Anthony's Health · Alton, IL
- Rush - Copley Medical Center · Aurora, IL
- Advocate Good Shepherd Hospital · Barrington, IL
- Illinois CancerCare-Bloomington · Bloomington, IL
- Loyola Center for Health at Burr Ridge · Burr Ridge, IL
- Illinois CancerCare-Canton · Canton, IL
- Memorial Hospital of Carbondale · Carbondale, IL
- SIH Cancer Institute · Carterville, IL
- Illinois CancerCare-Carthage · Carthage, IL
- Centralia Oncology Clinic · Centralia, IL
- Saint Mary's Hospital · Centralia, IL
- Advocate Illinois Masonic Medical Center · Chicago, IL
- Northwestern University · Chicago, IL
- Rush University Medical Center · Chicago, IL
- University of Illinois · Chicago, IL
- AMG Crystal Lake - Oncology · Crystal Lake, IL
- Carle at The Riverfront · Danville, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Northwestern Medicine Cancer Center Kishwaukee · DeKalb, IL
- Illinois CancerCare-Dixon · Dixon, IL
- Advocate Good Samaritan Hospital · Downers Grove, IL
- Carle Physician Group-Effingham · Effingham, IL
- Crossroads Cancer Center · Effingham, IL
- Advocate Sherman Hospital · Elgin, IL
- Elmhurst Memorial Hospital · Elmhurst, IL
- Illinois CancerCare-Eureka · Eureka, IL
- Illinois CancerCare-Galesburg · Galesburg, IL
- Western Illinois Cancer Treatment Center · Galesburg, IL
- Northwestern Medicine Cancer Center Delnor · Geneva, IL
- Advocate South Suburban Hospital · Hazel Crest, IL
- Loyola Medicine Homer Glen · Homer Glen, IL
- Illinois CancerCare-Kewanee Clinic · Kewanee, IL
- Northwestern Medicine Lake Forest Hospital · Lake Forest, IL
- AMG Libertyville - Oncology · Libertyville, IL
- Condell Memorial Hospital · Libertyville, IL
- Illinois CancerCare-Macomb · Macomb, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- Loyola University Medical Center · Maywood, IL
- Marjorie Weinberg Cancer Center at Loyola-Gottlieb · Melrose Park, IL
- Good Samaritan Regional Health Center · Mount Vernon, IL
- Edward Hospital/Cancer Center · Naperville, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- Advocate Christ Medical Center · Oak Lawn, IL
- Illinois CancerCare-Ottawa Clinic · Ottawa, IL
- Advocate Lutheran General Hospital · Park Ridge, IL
- Illinois CancerCare-Pekin · Pekin, IL
- Illinois CancerCare-Peoria · Peoria, IL
- Methodist Medical Center of Illinois · Peoria, IL
- Illinois CancerCare-Peru · Peru, IL
- Valley Radiation Oncology · Peru, IL
- Edward Hospital/Cancer Center?Plainfield · Plainfield, IL
- Illinois CancerCare-Princeton · Princeton, IL
- Memorial Medical Center · Springfield, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Springfield Clinic · Springfield, IL
- Carle Cancer Center · Urbana, IL
- The Carle Foundation Hospital · Urbana, IL
- Northwestern Medicine Cancer Center Warrenville · Warrenville, IL
- Illinois CancerCare - Washington · Washington, IL
- Rush-Copley Healthcare Center · Yorkville, IL
Indiana · 1
- Reid Health · Richmond, IN
Iowa · 6
- Mary Greeley Medical Center · Ames, IA
- McFarland Clinic - Ames · Ames, IA
- McFarland Clinic - Boone · Boone, IA
- McFarland Clinic - Trinity Cancer Center · Fort Dodge, IA
- McFarland Clinic - Jefferson · Jefferson, IA
- McFarland Clinic - Marshalltown · Marshalltown, IA
Kansas · 2
- Central Care Cancer Center - Garden City · Garden City, KS
- Central Care Cancer Center - Great Bend · Great Bend, KS
Kentucky · 1
- University of Kentucky/Markey Cancer Center · Lexington, KY
Louisiana · 5
- East Jefferson General Hospital · Metairie, LA
- LSU Healthcare Network / Metairie Multi-Specialty Clinic · Metairie, LA
- Louisiana State University Health Science Center · New Orleans, LA
- Tulane University Health Sciences Center · New Orleans, LA
- University Medical Center New Orleans · New Orleans, LA
Michigan · 18
- University of Michigan Comprehensive Cancer Center · Ann Arbor, MI
- Bronson Battle Creek · Battle Creek, MI
- University of Michigan - Brighton Center for Specialty Care · Brighton, MI
- Helen DeVos Children's Hospital at Spectrum Health · Grand Rapids, MI
- Spectrum Health at Butterworth Campus · Grand Rapids, MI
- Trinity Health Grand Rapids Hospital · Grand Rapids, MI
- Ascension Borgess Cancer Center · Kalamazoo, MI
- Borgess Medical Center · Kalamazoo, MI
- Bronson Methodist Hospital · Kalamazoo, MI
- West Michigan Cancer Center · Kalamazoo, MI
- Trinity Health Muskegon Hospital · Muskegon, MI
- Lakeland Hospital Niles · Niles, MI
- Cancer and Hematology Centers of Western Michigan - Norton Shores · Norton Shores, MI
- Spectrum Health Reed City Hospital · Reed City, MI
- Lakeland Medical Center Saint Joseph · Saint Joseph, MI
- Marie Yeager Cancer Center · Saint Joseph, MI
- Munson Medical Center · Traverse City, MI
- University of Michigan Health - West · Wyoming, MI
Minnesota · 4
- Minnesota Oncology - Burnsville · Burnsville, MN
- Cambridge Medical Center · Cambridge, MN
- Mercy Hospital · Coon Rapids, MN
- Fairview Southdale Hospital · Edina, MN
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.