Mechanisms of Fatigability With Diabetes

Summary

Pre-diabetes (Pre-D) is a precursor to type 2 diabetes (T2D) and characterized by increased exercise fatigability of lower limb muscles, that can impede exercise performance. The cause for the increased fatigability in people with Pre-D is not known. Given the profound vascular disease present in people who have had uncontrolled diabetes for several years, we will determine whether dynamic, fatiguing contractions of the lower limb muscles in people with Pre-D are limited by vascular dysfunction at multiple levels along the vascular tree including the artery, arteriole, and/or capillary.

Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov

Conditions studied

• Pre-diabetes
• Type 2 Diabetes

Eligibility basics and study details

Study type

Interventional

Phase

Not applicable

Ages

30 to 85 years

Sex

All

Healthy volunteers

Not accepted

Sponsor

University of Michigan

Last updated on ClinicalTrials.gov

September 1, 2026

These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.

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