Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

Summary

This phase II/III trial studies how well sentinel lymph node biopsy works and compares sentinel lymph node biopsy surgery to standard neck dissection as part of the treatment for early-stage oral cavity cancer. Sentinel lymph node biopsy surgery is a procedure that removes a smaller number of lymph nodes from your neck because it uses an imaging agent to see which lymph nodes are most likely to have cancer. Standard neck dissection, such as elective neck dissection, removes many of the lymph nodes in your neck.

Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov

Conditions studied

• Buccal Mucosa Squamous Cell Carcinoma
• Floor of Mouth Squamous Cell Carcinoma
• Gingival Squamous Cell Carcinoma
• Hard Palate Squamous Cell Carcinoma
• Lip Squamous Cell Carcinoma
• Lower Alveolar Ridge Squamous Cell Carcinoma
• Oral Cavity Squamous Cell Carcinoma
• Retromolar Trigone Squamous Cell Carcinoma
• Stage I Lip and Oral Cavity Cancer AJCC v8
• Stage II Lip and Oral Cavity Cancer AJCC v8
• Tongue Squamous Cell Carcinoma
• Upper Alveolar Ridge Squamous Cell Carcinoma

Eligibility basics and study details

Study type

Interventional

Phase

Phase 2/3

Ages

18 years and older

Sex

All

Healthy volunteers

Not accepted

Sponsor

NRG Oncology

Last updated on ClinicalTrials.gov

August 17, 2026

These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.

US recruiting sites