A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT
NCT04322318
This study is recruiting at 172 US sites in 47 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase II trial studies how well combination chemotherapy works in treating patients with newly diagnosed stage II-IV diffuse anaplastic Wilms tumors (DAWT) or favorable histology Wilms tumors (FHWT) that have come back (relapsed).
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Anaplastic Kidney Wilms Tumor
- Recurrent Kidney Wilms Tumor
- Stage II Kidney Wilms Tumor
- Stage III Kidney Wilms Tumor
- Stage IV Kidney Wilms Tumor
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2
- Ages
- Up to 30 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Children's Oncology Group
- Last updated on ClinicalTrials.gov
- August 25, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 2
- Children's Hospital of Alabama · Birmingham, AL
- USA Health Strada Patient Care Center · Mobile, AL
Alaska · 1
- Providence Alaska Medical Center · Anchorage, AK
Arizona · 3
- Banner Children's at Desert · Mesa, AZ
- Phoenix Childrens Hospital · Phoenix, AZ
- Banner University Medical Center - Tucson · Tucson, AZ
Arkansas · 1
- Arkansas Children's Hospital · Little Rock, AR
California · 14
- Kaiser Permanente Downey Medical Center · Downey, CA
- Loma Linda University Medical Center · Loma Linda, CA
- Miller Children's and Women's Hospital Long Beach · Long Beach, CA
- Cedars-Sinai Medical Center · Los Angeles, CA
- Children's Hospital Los Angeles · Los Angeles, CA
- Mattel Children's Hospital UCLA · Los Angeles, CA
- Valley Children's Hospital · Madera, CA
- Kaiser Permanente-Oakland · Oakland, CA
- UCSF Benioff Children's Hospital Oakland · Oakland, CA
- Children's Hospital of Orange County · Orange, CA
- Lucile Packard Children's Hospital Stanford University · Palo Alto, CA
- University of California Davis Comprehensive Cancer Center · Sacramento, CA
- Rady Children's Hospital - San Diego · San Diego, CA
- UCSF Medical Center-Mission Bay · San Francisco, CA
Colorado · 2
- Children's Hospital Colorado · Aurora, CO
- Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center · Denver, CO
Connecticut · 2
- Connecticut Children's Medical Center · Hartford, CT
- Yale University · New Haven, CT
Delaware · 1
- Alfred I duPont Hospital for Children · Wilmington, DE
District of Columbia · 2
- Children's National Medical Center · Washington D.C., DC
- MedStar Georgetown University Hospital · Washington D.C., DC
Florida · 14
- Broward Health Medical Center · Fort Lauderdale, FL
- Golisano Children's Hospital of Southwest Florida · Fort Myers, FL
- UF Health Cancer Institute - Gainesville · Gainesville, FL
- Memorial Regional Hospital/Joe DiMaggio Children's Hospital · Hollywood, FL
- Nemours Children's Clinic-Jacksonville · Jacksonville, FL
- Nicklaus Children's Hospital · Miami, FL
- University of Miami Miller School of Medicine-Sylvester Cancer Center · Miami, FL
- Arnold Palmer Hospital for Children · Orlando, FL
- Nemours Children's Hospital · Orlando, FL
- Nemours Children's Clinic - Pensacola · Pensacola, FL
- Johns Hopkins All Children's Hospital · St. Petersburg, FL
- Saint Joseph's Hospital/Children's Hospital-Tampa · Tampa, FL
- Tampa General Hospital · Tampa, FL
- Saint Mary's Medical Center · West Palm Beach, FL
Georgia · 4
- Children's Healthcare of Atlanta - Arthur M Blank Hospital · Atlanta, GA
- Augusta University Medical Center · Augusta, GA
- Atrium Health Navicent · Macon, GA
- Memorial Health University Medical Center · Savannah, GA
Hawaii · 1
- Kapiolani Medical Center for Women and Children · Honolulu, HI
Idaho · 1
- Saint Luke's Cancer Institute - Boise · Boise, ID
Illinois · 7
- Lurie Children's Hospital-Chicago · Chicago, IL
- University of Chicago Comprehensive Cancer Center · Chicago, IL
- Loyola University Medical Center · Maywood, IL
- Advocate Children's Hospital-Oak Lawn · Oak Lawn, IL
- Advocate Children's Hospital-Park Ridge · Park Ridge, IL
- OSF Children's Hospital of Illinois · Peoria, IL
- Southern Illinois University School of Medicine · Springfield, IL
Indiana · 2
- Ascension Saint Vincent Indianapolis Hospital · Indianapolis, IN
- Riley Hospital for Children · Indianapolis, IN
Iowa · 2
- Blank Children's Hospital · Des Moines, IA
- University of Iowa/Holden Comprehensive Cancer Center · Iowa City, IA
Kentucky · 2
- University of Kentucky/Markey Cancer Center · Lexington, KY
- Norton Children's Hospital · Louisville, KY
Louisiana · 2
- Children's Hospital New Orleans · New Orleans, LA
- Ochsner Medical Center Jefferson · New Orleans, LA
Maine · 2
- Eastern Maine Medical Center · Bangor, ME
- Maine Children's Cancer Program · Scarborough, ME
Maryland · 2
- Johns Hopkins University/Sidney Kimmel Cancer Center · Baltimore, MD
- Sinai Hospital of Baltimore · Baltimore, MD
Massachusetts · 2
- Dana-Farber Cancer Institute · Boston, MA
- UMass Memorial Medical Center - University Campus · Worcester, MA
Michigan · 5
- C S Mott Children's Hospital · Ann Arbor, MI
- Children's Hospital of Michigan · Detroit, MI
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital · Grand Rapids, MI
- Bronson Methodist Hospital · Kalamazoo, MI
- Corewell Health Children's · Royal Oak, MI
Minnesota · 3
- Children's Hospitals and Clinics of Minnesota - Minneapolis · Minneapolis, MN
- University of Minnesota/Masonic Cancer Center · Minneapolis, MN
- Mayo Clinic in Rochester · Rochester, MN
Mississippi · 1
- University of Mississippi Medical Center · Jackson, MS
Missouri · 5
- University of Missouri Children's Hospital · Columbia, MO
- Children's Mercy Hospitals and Clinics · Kansas City, MO
- Cardinal Glennon Children's Medical Center · St Louis, MO
- Mercy Hospital Saint Louis · St Louis, MO
- Washington University School of Medicine · St Louis, MO
Nebraska · 2
- Children's Hospital and Medical Center of Omaha · Omaha, NE
- University of Nebraska Medical Center · Omaha, NE
Nevada · 5
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation · Las Vegas, NV
- Summerlin Hospital Medical Center · Las Vegas, NV
- Sunrise Hospital and Medical Center · Las Vegas, NV
- University Medical Center of Southern Nevada · Las Vegas, NV
- Renown Regional Medical Center · Reno, NV
New Hampshire · 1
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center · Lebanon, NH
New Jersey · 6
- Hackensack University Medical Center · Hackensack, NJ
- Morristown Medical Center · Morristown, NJ
- Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital · New Brunswick, NJ
- Saint Peter's University Hospital · New Brunswick, NJ
- Newark Beth Israel Medical Center · Newark, NJ
- Saint Joseph's Regional Medical Center · Paterson, NJ
New Mexico · 2
- Presbyterian Hospital · Albuquerque, NM
- University of New Mexico Cancer Center · Albuquerque, NM
New York · 12
- Albany Medical Center · Albany, NY
- Roswell Park Cancer Institute · Buffalo, NY
- The Steven and Alexandra Cohen Children's Medical Center of New York · New Hyde Park, NY
- Memorial Sloan Kettering Cancer Center · New York, NY
- Mount Sinai Hospital · New York, NY
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center · New York, NY
- NYP/Weill Cornell Medical Center · New York, NY
- University of Rochester · Rochester, NY
- Stony Brook University Medical Center · Stony Brook, NY
- State University of New York Upstate Medical University · Syracuse, NY
- Montefiore Medical Center - Moses Campus · The Bronx, NY
- New York Medical College · Valhalla, NY
North Carolina · 6
- Mission Hospital · Asheville, NC
- Carolinas Medical Center/Levine Cancer Institute · Charlotte, NC
- Novant Health Presbyterian Medical Center · Charlotte, NC
- Duke University Medical Center · Durham, NC
- East Carolina University · Greenville, NC
- Wake Forest University Health Sciences · Winston-Salem, NC
North Dakota · 1
- Sanford Broadway Medical Center · Fargo, ND
Ohio · 7
- Children's Hospital Medical Center of Akron · Akron, OH
- Cincinnati Children's Hospital Medical Center · Cincinnati, OH
- Cleveland Clinic Foundation · Cleveland, OH
- Rainbow Babies and Childrens Hospital · Cleveland, OH
- Nationwide Children's Hospital · Columbus, OH
- Dayton Children's Hospital · Dayton, OH
- ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital · Toledo, OH
Oklahoma · 1
- University of Oklahoma Health Sciences Center · Oklahoma City, OK
Oregon · 2
- Legacy Emanuel Children's Hospital · Portland, OR
- Oregon Health and Science University · Portland, OR
Pennsylvania · 6
- Lehigh Valley Hospital-Cedar Crest · Allentown, PA
- Geisinger Medical Center · Danville, PA
- Penn State Children's Hospital · Hershey, PA
- Children's Hospital of Philadelphia · Philadelphia, PA
- Saint Christopher's Hospital for Children · Philadelphia, PA
- Children's Hospital of Pittsburgh of UPMC · Pittsburgh, PA
Rhode Island · 1
- Rhode Island Hospital · Providence, RI
South Carolina · 3
- Medical University of South Carolina · Charleston, SC
- Prisma Health Richland Hospital · Columbia, SC
- BI-LO Charities Children's Cancer Center · Greenville, SC
South Dakota · 1
- Sanford USD Medical Center - Sioux Falls · Sioux Falls, SD
Tennessee · 4
- East Tennessee Childrens Hospital · Knoxville, TN
- Saint Jude Children's Research Hospital · Memphis, TN
- The Children's Hospital at TriStar Centennial · Nashville, TN
- Vanderbilt University/Ingram Cancer Center · Nashville, TN
Texas · 7
- Dell Children's Medical Center of Central Texas · Austin, TX
- Driscoll Children's Hospital · Corpus Christi, TX
- Medical City Dallas Hospital · Dallas, TX
- UT Southwestern/Simmons Cancer Center-Dallas · Dallas, TX
- El Paso Children's Hospital · El Paso, TX
- Cook Children's Medical Center · Fort Worth, TX
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center · Houston, TX
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.